Physicochemical characterization of the formation of chitosan/xanthan gum-based polyelectrolyte complexes as ibuprofen carriers
Fizičko‐hemijska karakterizacija formiranja polielektrolitnih kompleksa hitozan/ksantan guma kao nosača ibuprofena
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
By mixing the dispersions of oppositely charged polymers, intermolecular interactions
are established and polyelectrolyte complexes (PECs) are formed. These interactions can
differ in strength and extent, which can be influenced by the presence of the drug in the
complex (1). The aim of this study was the physicochemical characterization of the formation
of chitosan (CH)/xanthan gum (XG)-based placebo and ibuprofen-loaded PEC. The course of
the PECs formation process was monitored by measuring the transmittance, which was
reduced by adding XG dispersion, without or with ibuprofen, into CH dispersion whose initial
transmittance was 97.53±0.64%. The final transmittance was 11.51±2.98% for placebo and
0.29±0.10% for ibuprofen-loaded PEC. The decrease in transmittance indicated the
formation of complexes by establishing interactions between polymers and ibuprofen. CH
dispersion had a Newtonian type of flow, while XG dispersions without and with ibuprofen
and PEC hydrogels had ps...eudoplastic flow with thixotropy. The maximum apparent
viscosities (ηmax at 22.2 s -1) of PEC hydrogels (1.65±0.06 Pa·s for placebo and 2.18±0.04 Pa·s
for ibuprofen-loaded PEC) were higher compared to the dynamic viscosity of CH dispersion
(0.09±0.01 Pa·s) and ηmax of XG dispersion without (0.20±0.00 Pa·s) and with ibuprofen
(0.22±0.00 Pa·s). The measured increase of maximum apparent viscosities in PEC hydrogels
confirmed the formation of complexes. Higher apparent viscosities corresponded to stronger
interactions within PECs (2). Interactions were stronger in ibuprofen-loaded compared to
placebo PEC, so it can be assumed that the ibuprofen entrapment can result in its controlled
release from the carrier.
Mešanjem disperzija suprotno naelektrisanih polimera dolazi do uspostavljanja
međumolekulskih interakcija i formiranja polielektrolitnih kompleksa (PEK). Ove interakcije
mogu biti različite jačine i obima, na šta može uticati i prisustvo lekovite supstance u
kompleksu (1). Cilj ovog istraživanja bila je fizičko-hemijska karakterizacija formiranja
placebo i PEK sa ibuprofenom na bazi hitozana (H) i ksantan gume (KG). Tok procesa
formiranja PEK praćen je merenjem transmitance, koja se smanjivala dodavanjem disperzije
KG, sa ili bez ibuprofena, u disperziju H čija je inicijalna transmitanca bila 97,53±0,64%. Kod
placebo PEK finalna transmitanca bila je 11,51±2,98%, a kod PEK sa ibuprofenom
0,29±0,10%. Smanjenje transmitance ukazalo je na očekivano formiranje kompleksa
uspostavljanjem interakcija između polimera i ibuprofena. Disperzija H imala je njutnovski
tip proticanja, a disperzije KG sa i bez ibuprofena i PEK hidrogelovi, pseudoplastično
proticanje sa tiksotropijom. Maksim...alni prividni viskoziteti (ηmax na 22,2 s -1 ) PEK
hidrogelova bili su 1,65±0,06 Pa·s (placebo PEK) i 2,18±0,04 Pa·s (PEK sa ibuprofenom), što
je bilo veće u poređenju sa dinamičkim viskozitetom disperzije H (0,09±0,01 Pa·s) i ηmax
disperzije KG bez (0,20±0,00 Pa·s) i sa ibuprofenom (0,22±0,00 Pa·s). Izmereni porast
maksimalnog prividnog viskoziteta u PEK hidrogelovima potvrdio je formiranje PEK i
uspostavljanje karakterističnih interakcija između njegovih komponenata. Veći prividni
viskoziteti odgovarali su jačim i obimnijim interakcijama unutar PEK (2). Interakcije su bile
jače u PEK sa ibuprofenom u odnosu na placebo PEK, pa se može pretpostaviti da bi se
inkorporiranjem ibuprofena u PEK moglo postići njegovo kontrolisano oslobađanje iz
nosača.
Извор:
Arhiv za farmaciju, 2022, 72, 4 suplement, S239-S240Издавач:
- Savez farmaceutskih udruženja Srbije (SFUS)
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
Напомена:
- VIII Kongres farmaceuta Srbije sa međunarodnim učešćem, 12-15.10.2022. Beograd
Институција/група
PharmacyTY - CONF AU - Ćirić, Ana AU - Đekić, Ljiljana PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4522 AB - By mixing the dispersions of oppositely charged polymers, intermolecular interactions are established and polyelectrolyte complexes (PECs) are formed. These interactions can differ in strength and extent, which can be influenced by the presence of the drug in the complex (1). The aim of this study was the physicochemical characterization of the formation of chitosan (CH)/xanthan gum (XG)-based placebo and ibuprofen-loaded PEC. The course of the PECs formation process was monitored by measuring the transmittance, which was reduced by adding XG dispersion, without or with ibuprofen, into CH dispersion whose initial transmittance was 97.53±0.64%. The final transmittance was 11.51±2.98% for placebo and 0.29±0.10% for ibuprofen-loaded PEC. The decrease in transmittance indicated the formation of complexes by establishing interactions between polymers and ibuprofen. CH dispersion had a Newtonian type of flow, while XG dispersions without and with ibuprofen and PEC hydrogels had pseudoplastic flow with thixotropy. The maximum apparent viscosities (ηmax at 22.2 s -1) of PEC hydrogels (1.65±0.06 Pa·s for placebo and 2.18±0.04 Pa·s for ibuprofen-loaded PEC) were higher compared to the dynamic viscosity of CH dispersion (0.09±0.01 Pa·s) and ηmax of XG dispersion without (0.20±0.00 Pa·s) and with ibuprofen (0.22±0.00 Pa·s). The measured increase of maximum apparent viscosities in PEC hydrogels confirmed the formation of complexes. Higher apparent viscosities corresponded to stronger interactions within PECs (2). Interactions were stronger in ibuprofen-loaded compared to placebo PEC, so it can be assumed that the ibuprofen entrapment can result in its controlled release from the carrier. AB - Mešanjem disperzija suprotno naelektrisanih polimera dolazi do uspostavljanja međumolekulskih interakcija i formiranja polielektrolitnih kompleksa (PEK). Ove interakcije mogu biti različite jačine i obima, na šta može uticati i prisustvo lekovite supstance u kompleksu (1). Cilj ovog istraživanja bila je fizičko-hemijska karakterizacija formiranja placebo i PEK sa ibuprofenom na bazi hitozana (H) i ksantan gume (KG). Tok procesa formiranja PEK praćen je merenjem transmitance, koja se smanjivala dodavanjem disperzije KG, sa ili bez ibuprofena, u disperziju H čija je inicijalna transmitanca bila 97,53±0,64%. Kod placebo PEK finalna transmitanca bila je 11,51±2,98%, a kod PEK sa ibuprofenom 0,29±0,10%. Smanjenje transmitance ukazalo je na očekivano formiranje kompleksa uspostavljanjem interakcija između polimera i ibuprofena. Disperzija H imala je njutnovski tip proticanja, a disperzije KG sa i bez ibuprofena i PEK hidrogelovi, pseudoplastično proticanje sa tiksotropijom. Maksimalni prividni viskoziteti (ηmax na 22,2 s -1 ) PEK hidrogelova bili su 1,65±0,06 Pa·s (placebo PEK) i 2,18±0,04 Pa·s (PEK sa ibuprofenom), što je bilo veće u poređenju sa dinamičkim viskozitetom disperzije H (0,09±0,01 Pa·s) i ηmax disperzije KG bez (0,20±0,00 Pa·s) i sa ibuprofenom (0,22±0,00 Pa·s). Izmereni porast maksimalnog prividnog viskoziteta u PEK hidrogelovima potvrdio je formiranje PEK i uspostavljanje karakterističnih interakcija između njegovih komponenata. Veći prividni viskoziteti odgovarali su jačim i obimnijim interakcijama unutar PEK (2). Interakcije su bile jače u PEK sa ibuprofenom u odnosu na placebo PEK, pa se može pretpostaviti da bi se inkorporiranjem ibuprofena u PEK moglo postići njegovo kontrolisano oslobađanje iz nosača. PB - Savez farmaceutskih udruženja Srbije (SFUS) C3 - Arhiv za farmaciju T1 - Physicochemical characterization of the formation of chitosan/xanthan gum-based polyelectrolyte complexes as ibuprofen carriers T1 - Fizičko‐hemijska karakterizacija formiranja polielektrolitnih kompleksa hitozan/ksantan guma kao nosača ibuprofena VL - 72 IS - 4 suplement SP - S239 EP - S240 UR - https://hdl.handle.net/21.15107/rcub_farfar_4522 ER -
@conference{ author = "Ćirić, Ana and Đekić, Ljiljana", year = "2022", abstract = "By mixing the dispersions of oppositely charged polymers, intermolecular interactions are established and polyelectrolyte complexes (PECs) are formed. These interactions can differ in strength and extent, which can be influenced by the presence of the drug in the complex (1). The aim of this study was the physicochemical characterization of the formation of chitosan (CH)/xanthan gum (XG)-based placebo and ibuprofen-loaded PEC. The course of the PECs formation process was monitored by measuring the transmittance, which was reduced by adding XG dispersion, without or with ibuprofen, into CH dispersion whose initial transmittance was 97.53±0.64%. The final transmittance was 11.51±2.98% for placebo and 0.29±0.10% for ibuprofen-loaded PEC. The decrease in transmittance indicated the formation of complexes by establishing interactions between polymers and ibuprofen. CH dispersion had a Newtonian type of flow, while XG dispersions without and with ibuprofen and PEC hydrogels had pseudoplastic flow with thixotropy. The maximum apparent viscosities (ηmax at 22.2 s -1) of PEC hydrogels (1.65±0.06 Pa·s for placebo and 2.18±0.04 Pa·s for ibuprofen-loaded PEC) were higher compared to the dynamic viscosity of CH dispersion (0.09±0.01 Pa·s) and ηmax of XG dispersion without (0.20±0.00 Pa·s) and with ibuprofen (0.22±0.00 Pa·s). The measured increase of maximum apparent viscosities in PEC hydrogels confirmed the formation of complexes. Higher apparent viscosities corresponded to stronger interactions within PECs (2). Interactions were stronger in ibuprofen-loaded compared to placebo PEC, so it can be assumed that the ibuprofen entrapment can result in its controlled release from the carrier., Mešanjem disperzija suprotno naelektrisanih polimera dolazi do uspostavljanja međumolekulskih interakcija i formiranja polielektrolitnih kompleksa (PEK). Ove interakcije mogu biti različite jačine i obima, na šta može uticati i prisustvo lekovite supstance u kompleksu (1). Cilj ovog istraživanja bila je fizičko-hemijska karakterizacija formiranja placebo i PEK sa ibuprofenom na bazi hitozana (H) i ksantan gume (KG). Tok procesa formiranja PEK praćen je merenjem transmitance, koja se smanjivala dodavanjem disperzije KG, sa ili bez ibuprofena, u disperziju H čija je inicijalna transmitanca bila 97,53±0,64%. Kod placebo PEK finalna transmitanca bila je 11,51±2,98%, a kod PEK sa ibuprofenom 0,29±0,10%. Smanjenje transmitance ukazalo je na očekivano formiranje kompleksa uspostavljanjem interakcija između polimera i ibuprofena. Disperzija H imala je njutnovski tip proticanja, a disperzije KG sa i bez ibuprofena i PEK hidrogelovi, pseudoplastično proticanje sa tiksotropijom. Maksimalni prividni viskoziteti (ηmax na 22,2 s -1 ) PEK hidrogelova bili su 1,65±0,06 Pa·s (placebo PEK) i 2,18±0,04 Pa·s (PEK sa ibuprofenom), što je bilo veće u poređenju sa dinamičkim viskozitetom disperzije H (0,09±0,01 Pa·s) i ηmax disperzije KG bez (0,20±0,00 Pa·s) i sa ibuprofenom (0,22±0,00 Pa·s). Izmereni porast maksimalnog prividnog viskoziteta u PEK hidrogelovima potvrdio je formiranje PEK i uspostavljanje karakterističnih interakcija između njegovih komponenata. Veći prividni viskoziteti odgovarali su jačim i obimnijim interakcijama unutar PEK (2). Interakcije su bile jače u PEK sa ibuprofenom u odnosu na placebo PEK, pa se može pretpostaviti da bi se inkorporiranjem ibuprofena u PEK moglo postići njegovo kontrolisano oslobađanje iz nosača.", publisher = "Savez farmaceutskih udruženja Srbije (SFUS)", journal = "Arhiv za farmaciju", title = "Physicochemical characterization of the formation of chitosan/xanthan gum-based polyelectrolyte complexes as ibuprofen carriers, Fizičko‐hemijska karakterizacija formiranja polielektrolitnih kompleksa hitozan/ksantan guma kao nosača ibuprofena", volume = "72", number = "4 suplement", pages = "S239-S240", url = "https://hdl.handle.net/21.15107/rcub_farfar_4522" }
Ćirić, A.,& Đekić, L.. (2022). Physicochemical characterization of the formation of chitosan/xanthan gum-based polyelectrolyte complexes as ibuprofen carriers. in Arhiv za farmaciju Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S239-S240. https://hdl.handle.net/21.15107/rcub_farfar_4522
Ćirić A, Đekić L. Physicochemical characterization of the formation of chitosan/xanthan gum-based polyelectrolyte complexes as ibuprofen carriers. in Arhiv za farmaciju. 2022;72(4 suplement):S239-S240. https://hdl.handle.net/21.15107/rcub_farfar_4522 .
Ćirić, Ana, Đekić, Ljiljana, "Physicochemical characterization of the formation of chitosan/xanthan gum-based polyelectrolyte complexes as ibuprofen carriers" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S239-S240, https://hdl.handle.net/21.15107/rcub_farfar_4522 .