Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers
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The processing of liquisolid systems (LSS), which are considered a promising approach
to improving the oral bioavailability of poorly soluble drugs, has proven challenging due to the
relatively high amount of liquid phase incorporated within them. The objective of this study was to
apply machine-learning tools to better understand the effects of formulation factors and/or tableting
process parameters on the flowability and compaction properties of LSS with silica-based mesoporous
excipients as carriers. In addition, the results of the flowability testing and dynamic compaction
analysis of liquisolid admixtures were used to build data sets and develop predictive multivariate
models. In the regression analysis, six different algorithms were used to model the relationship
between tensile strength (TS), the target variable, and eight other input variables. The AdaBoost
algorithm provided the best-fit model for predicting TS (coefficient of determination = 0.94), with
ejection str...ess (ES), compaction pressure, and carrier type being the parameters that influenced its
performance the most. The same algorithm was best for classification (precision = 0.90), depending on
the type of carrier used, with detachment stress, ES, and TS as variables affecting the performance of
the model. Furthermore, the formulations with Neusilin® US2 were able to maintain good flowability
and satisfactory values of TS despite having a higher liquid load compared to the other two carriers.
Keywords:
liquisolid systems / mesoporous silica carrier / flowability / direct compression / compaction behavior / machine-learningSource:
Pharmaceutics, 2023, 15, 3, 741-761Publisher:
- MDPI
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PharmacyTY - JOUR AU - Glišić, Teodora AU - Đuriš, Jelena AU - Vasiljević, Ivana AU - Parojčić, Jelena AU - Aleksić, Ivana PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4581 AB - The processing of liquisolid systems (LSS), which are considered a promising approach to improving the oral bioavailability of poorly soluble drugs, has proven challenging due to the relatively high amount of liquid phase incorporated within them. The objective of this study was to apply machine-learning tools to better understand the effects of formulation factors and/or tableting process parameters on the flowability and compaction properties of LSS with silica-based mesoporous excipients as carriers. In addition, the results of the flowability testing and dynamic compaction analysis of liquisolid admixtures were used to build data sets and develop predictive multivariate models. In the regression analysis, six different algorithms were used to model the relationship between tensile strength (TS), the target variable, and eight other input variables. The AdaBoost algorithm provided the best-fit model for predicting TS (coefficient of determination = 0.94), with ejection stress (ES), compaction pressure, and carrier type being the parameters that influenced its performance the most. The same algorithm was best for classification (precision = 0.90), depending on the type of carrier used, with detachment stress, ES, and TS as variables affecting the performance of the model. Furthermore, the formulations with Neusilin® US2 were able to maintain good flowability and satisfactory values of TS despite having a higher liquid load compared to the other two carriers. PB - MDPI T2 - Pharmaceutics T1 - Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers VL - 15 IS - 3 SP - 741 EP - 761 DO - 10.3390/pharmaceutics15030741 ER -
@article{ author = "Glišić, Teodora and Đuriš, Jelena and Vasiljević, Ivana and Parojčić, Jelena and Aleksić, Ivana", year = "2023", abstract = "The processing of liquisolid systems (LSS), which are considered a promising approach to improving the oral bioavailability of poorly soluble drugs, has proven challenging due to the relatively high amount of liquid phase incorporated within them. The objective of this study was to apply machine-learning tools to better understand the effects of formulation factors and/or tableting process parameters on the flowability and compaction properties of LSS with silica-based mesoporous excipients as carriers. In addition, the results of the flowability testing and dynamic compaction analysis of liquisolid admixtures were used to build data sets and develop predictive multivariate models. In the regression analysis, six different algorithms were used to model the relationship between tensile strength (TS), the target variable, and eight other input variables. The AdaBoost algorithm provided the best-fit model for predicting TS (coefficient of determination = 0.94), with ejection stress (ES), compaction pressure, and carrier type being the parameters that influenced its performance the most. The same algorithm was best for classification (precision = 0.90), depending on the type of carrier used, with detachment stress, ES, and TS as variables affecting the performance of the model. Furthermore, the formulations with Neusilin® US2 were able to maintain good flowability and satisfactory values of TS despite having a higher liquid load compared to the other two carriers.", publisher = "MDPI", journal = "Pharmaceutics", title = "Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers", volume = "15", number = "3", pages = "741-761", doi = "10.3390/pharmaceutics15030741" }
Glišić, T., Đuriš, J., Vasiljević, I., Parojčić, J.,& Aleksić, I.. (2023). Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers. in Pharmaceutics MDPI., 15(3), 741-761. https://doi.org/10.3390/pharmaceutics15030741
Glišić T, Đuriš J, Vasiljević I, Parojčić J, Aleksić I. Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers. in Pharmaceutics. 2023;15(3):741-761. doi:10.3390/pharmaceutics15030741 .
Glišić, Teodora, Đuriš, Jelena, Vasiljević, Ivana, Parojčić, Jelena, Aleksić, Ivana, "Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers" in Pharmaceutics, 15, no. 3 (2023):741-761, https://doi.org/10.3390/pharmaceutics15030741 . .