Приказ основних података о документу
Optimization of the RP-HPLC method for multicomponent analgetic drug determination.
dc.creator | Ivanović, D | |
dc.creator | Medenica, Mirjana | |
dc.creator | Malenović, Anđelija | |
dc.creator | Jančić, Biljana | |
dc.creator | Misljenović, D | |
dc.date.accessioned | 2019-09-02T10:57:40Z | |
dc.date.available | 2019-09-02T10:57:40Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0006-6648 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/460 | |
dc.description.abstract | The optimization of RP-HPLC method defined the simultaneous influence of some important conditions, such as the mobile phase composition, pH of the mobile phase and temperature, on the separation and determination. The RP-HPLC method was done for the determination of paracetamol, caffeine and propyphenazone in a multicomponent pharmaceutical dosage form. The separation factor values define the optimal conditions, which were confirmed by analysing the appropriate mathematical models. The chromatographic system Hewlett Packard 1100 consisted of a HP 1100 pump, HP 1100 UV-VIS detector and HP integrator. Separations were performed on a Beckman Ultrasphere ODS 4.6 x 150 mm, 5 microns particle size column. Samples were introduced through a Rheodyne injector valve with a 20 microL sample loop. UV detection was performed at 265 nm and phenobarottons was used as an internal standard. The optimization was performed within the pH range from 2.5 to 6.0; temperature range from 20 degrees C to 55 degrees C and composition of the mobile phase methanol-water from (30:70 V/V) to (65:35 V/V). The three-D graphs, constructed with sixty-four experimental points, confirmed the optimal conditions for the determination of the investigated analgetic drugs. | en |
dc.rights | restrictedAccess | |
dc.source | Bollettino chimico farmaceutico | |
dc.title | Optimization of the RP-HPLC method for multicomponent analgetic drug determination. | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Мисљеновић, Д; Јанчић, Биљана; Маленовић, Aнђелија; Меденица, Мирјана; Ивановић, Д; | |
dc.citation.volume | 142 | |
dc.citation.issue | 9 | |
dc.citation.spage | 386 | |
dc.citation.epage | 389 | |
dc.citation.other | 142(9): 386-389 | |
dc.identifier.scopus | 2-s2.0-1542715918 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_460 | |
dc.type.version | publishedVersion |
Документи
Датотеке | Величина | Формат | Преглед |
---|---|---|---|
Уз овај запис нема датотека. |