Lipids in tinder fungus, Fomes fometarius (L.) Fr., Polyporaceae
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Tinder fungus, Fomes fomentarius (L.) Fr. (Polyporaceae), is a large, woody, perennial fungus. It is a plant pathogen which grows on the beech and other deciduous species as a parasite or saprophyte causing a heart rot of the wood. Some studies have shown that F. fomentarius has hypoglycemic, anti-nociceptive, anti-inflammatory, anti-infective and anti-tumor effect. Several classes of metabolites were identified: primary metabolites i.e., proteins, polysaccharides (β-glucans), polysaccharide-protein complexes, and secondary metabolites such as triterpenes and sterols, organic acids, benzofurans, coumarins, volatile components. GC/MS analysis of cyclohexane extract of fungus collected on mountain Avala in 2017 have shown the presence of sterols: ergosta-5,7,22-trien-3-ol (46.8%); ergosta-7,22-dien-3-ol (25.4%); ergosta-7,22-dien-3-on (15.9%); ergost-7-en-3-ol (fungisterol, kampesterol) (4.3%); 5,6-dihidro-3-ergosterol (5.5%). Fatty acids were also determined, including palmitic acid (C1...6:0) 34.0%, stearic acid (C18:0) 18.0%, linoleic acid (C18:2n6c) 10.8%, heneicosanoic acid (C21:0) (5.6%), behenic acid (C22:0) (10.9%), tricosanoic acid (C23:0) (18.4%) and lignoceric acid (C24:0) (2.3%). Cyclohexane extract has shown antibacterial activity against several bacterial strains including Helicobacter pylori and significant cytotoxic activity against HeLa cell line with an IC50 25.10±7.16 (μg/mL). These activities could be due to the presence of cytotoxic fatty acids.
Keywords:
tinder fungus / Fomes fometarius / lipidsSource:
14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts, 2022, 140-140Publisher:
- Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš
- Institute for Nature Conservation of Serbia, Belgrade
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Note:
- 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, Kladovo, 26th to 29th June 2022
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PharmacyTY - CONF AU - Radović, Jelena AU - Kundaković-Vasović, Tatjana PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4620 AB - Tinder fungus, Fomes fomentarius (L.) Fr. (Polyporaceae), is a large, woody, perennial fungus. It is a plant pathogen which grows on the beech and other deciduous species as a parasite or saprophyte causing a heart rot of the wood. Some studies have shown that F. fomentarius has hypoglycemic, anti-nociceptive, anti-inflammatory, anti-infective and anti-tumor effect. Several classes of metabolites were identified: primary metabolites i.e., proteins, polysaccharides (β-glucans), polysaccharide-protein complexes, and secondary metabolites such as triterpenes and sterols, organic acids, benzofurans, coumarins, volatile components. GC/MS analysis of cyclohexane extract of fungus collected on mountain Avala in 2017 have shown the presence of sterols: ergosta-5,7,22-trien-3-ol (46.8%); ergosta-7,22-dien-3-ol (25.4%); ergosta-7,22-dien-3-on (15.9%); ergost-7-en-3-ol (fungisterol, kampesterol) (4.3%); 5,6-dihidro-3-ergosterol (5.5%). Fatty acids were also determined, including palmitic acid (C16:0) 34.0%, stearic acid (C18:0) 18.0%, linoleic acid (C18:2n6c) 10.8%, heneicosanoic acid (C21:0) (5.6%), behenic acid (C22:0) (10.9%), tricosanoic acid (C23:0) (18.4%) and lignoceric acid (C24:0) (2.3%). Cyclohexane extract has shown antibacterial activity against several bacterial strains including Helicobacter pylori and significant cytotoxic activity against HeLa cell line with an IC50 25.10±7.16 (μg/mL). These activities could be due to the presence of cytotoxic fatty acids. PB - Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš PB - Institute for Nature Conservation of Serbia, Belgrade C3 - 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts T1 - Lipids in tinder fungus, Fomes fometarius (L.) Fr., Polyporaceae SP - 140 EP - 140 UR - https://hdl.handle.net/21.15107/rcub_farfar_4620 ER -
@conference{ author = "Radović, Jelena and Kundaković-Vasović, Tatjana", year = "2022", abstract = "Tinder fungus, Fomes fomentarius (L.) Fr. (Polyporaceae), is a large, woody, perennial fungus. It is a plant pathogen which grows on the beech and other deciduous species as a parasite or saprophyte causing a heart rot of the wood. Some studies have shown that F. fomentarius has hypoglycemic, anti-nociceptive, anti-inflammatory, anti-infective and anti-tumor effect. Several classes of metabolites were identified: primary metabolites i.e., proteins, polysaccharides (β-glucans), polysaccharide-protein complexes, and secondary metabolites such as triterpenes and sterols, organic acids, benzofurans, coumarins, volatile components. GC/MS analysis of cyclohexane extract of fungus collected on mountain Avala in 2017 have shown the presence of sterols: ergosta-5,7,22-trien-3-ol (46.8%); ergosta-7,22-dien-3-ol (25.4%); ergosta-7,22-dien-3-on (15.9%); ergost-7-en-3-ol (fungisterol, kampesterol) (4.3%); 5,6-dihidro-3-ergosterol (5.5%). Fatty acids were also determined, including palmitic acid (C16:0) 34.0%, stearic acid (C18:0) 18.0%, linoleic acid (C18:2n6c) 10.8%, heneicosanoic acid (C21:0) (5.6%), behenic acid (C22:0) (10.9%), tricosanoic acid (C23:0) (18.4%) and lignoceric acid (C24:0) (2.3%). Cyclohexane extract has shown antibacterial activity against several bacterial strains including Helicobacter pylori and significant cytotoxic activity against HeLa cell line with an IC50 25.10±7.16 (μg/mL). These activities could be due to the presence of cytotoxic fatty acids.", publisher = "Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Institute for Nature Conservation of Serbia, Belgrade", journal = "14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts", title = "Lipids in tinder fungus, Fomes fometarius (L.) Fr., Polyporaceae", pages = "140-140", url = "https://hdl.handle.net/21.15107/rcub_farfar_4620" }
Radović, J.,& Kundaković-Vasović, T.. (2022). Lipids in tinder fungus, Fomes fometarius (L.) Fr., Polyporaceae. in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš., 140-140. https://hdl.handle.net/21.15107/rcub_farfar_4620
Radović J, Kundaković-Vasović T. Lipids in tinder fungus, Fomes fometarius (L.) Fr., Polyporaceae. in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts. 2022;:140-140. https://hdl.handle.net/21.15107/rcub_farfar_4620 .
Radović, Jelena, Kundaković-Vasović, Tatjana, "Lipids in tinder fungus, Fomes fometarius (L.) Fr., Polyporaceae" in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts (2022):140-140, https://hdl.handle.net/21.15107/rcub_farfar_4620 .