Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?
Authors
Ranković, Maja
Jevremović, Anka

Janošević-Ležaić, Aleksandra

Arsenijević, Aleksandar
Rupar, Jelena

Dobričić, Vladimir

Nedić Vasiljević, Bojana

Gavrilov, Nemanja
Bajuk-Bogdanović, Danica

Milojević-Rakić, Maja

Article (Published version)
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Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was employed for drug quantification. The effects of the tested compounds on cell viability were evaluated using in vitro methylthiazol-tetrazolium (MTT) colorimetric technique against human colorectal carcinoma (cell line HCT-116) and MRC-5 fibroblasts. Zeolite structure remained unchanged during homogeneous drug impregnation with achieved drug loadings in the 18–21 mg/g range. The highest drug release, in the µM concentration range, with favourable kinetics was established for zeolite-supported 9-aminoacridine. The acridine delivery via zeolite carrier is viewed in terms of solvation energy and zeolite adsorption sites. The cytotoxic effect of supported acridines on HCT-116 cells reveals that... the zeolite carrier improves toxicity, while the highest efficiency is displayed by zeolite-impregnated 9-aminoacridine. The 9-aminoacridine delivery via zeolite carrier favours healthy tissue preservation while accompanying increased toxicity toward cancer cells. Cytotoxicity results are well correlated with theoretical modelling and release study, providing promising results for applicative purposes.
Keywords:
acridine derivatives / anticancer / cytotoxicity / drug release / zeoliteSource:
Journal of Functional Biomaterials, 2023, 14, 3Publisher:
- MDPI
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200111 (University of Kragujevac, Faculty of Medicine) (RS-200111)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200161 (University of Belgrade, Faculty of Pharmacy) (RS-200161)
- Grant for collaboration with JINR Dubna (JINR-Serbia_P12)
DOI: 10.3390/jfb14030173
ISSN: 2079-4983
PubMed: 36976097
Scopus: 2-s2.0-85151166954
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Institution/Community
PharmacyTY - JOUR AU - Ranković, Maja AU - Jevremović, Anka AU - Janošević-Ležaić, Aleksandra AU - Arsenijević, Aleksandar AU - Rupar, Jelena AU - Dobričić, Vladimir AU - Nedić Vasiljević, Bojana AU - Gavrilov, Nemanja AU - Bajuk-Bogdanović, Danica AU - Milojević-Rakić, Maja PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4649 AB - Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was employed for drug quantification. The effects of the tested compounds on cell viability were evaluated using in vitro methylthiazol-tetrazolium (MTT) colorimetric technique against human colorectal carcinoma (cell line HCT-116) and MRC-5 fibroblasts. Zeolite structure remained unchanged during homogeneous drug impregnation with achieved drug loadings in the 18–21 mg/g range. The highest drug release, in the µM concentration range, with favourable kinetics was established for zeolite-supported 9-aminoacridine. The acridine delivery via zeolite carrier is viewed in terms of solvation energy and zeolite adsorption sites. The cytotoxic effect of supported acridines on HCT-116 cells reveals that the zeolite carrier improves toxicity, while the highest efficiency is displayed by zeolite-impregnated 9-aminoacridine. The 9-aminoacridine delivery via zeolite carrier favours healthy tissue preservation while accompanying increased toxicity toward cancer cells. Cytotoxicity results are well correlated with theoretical modelling and release study, providing promising results for applicative purposes. PB - MDPI T2 - Journal of Functional Biomaterials T1 - Can Zeolite-Supporting Acridines Boost Their Anticancer Performance? VL - 14 IS - 3 DO - 10.3390/jfb14030173 ER -
@article{ author = "Ranković, Maja and Jevremović, Anka and Janošević-Ležaić, Aleksandra and Arsenijević, Aleksandar and Rupar, Jelena and Dobričić, Vladimir and Nedić Vasiljević, Bojana and Gavrilov, Nemanja and Bajuk-Bogdanović, Danica and Milojević-Rakić, Maja", year = "2023", abstract = "Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was employed for drug quantification. The effects of the tested compounds on cell viability were evaluated using in vitro methylthiazol-tetrazolium (MTT) colorimetric technique against human colorectal carcinoma (cell line HCT-116) and MRC-5 fibroblasts. Zeolite structure remained unchanged during homogeneous drug impregnation with achieved drug loadings in the 18–21 mg/g range. The highest drug release, in the µM concentration range, with favourable kinetics was established for zeolite-supported 9-aminoacridine. The acridine delivery via zeolite carrier is viewed in terms of solvation energy and zeolite adsorption sites. The cytotoxic effect of supported acridines on HCT-116 cells reveals that the zeolite carrier improves toxicity, while the highest efficiency is displayed by zeolite-impregnated 9-aminoacridine. The 9-aminoacridine delivery via zeolite carrier favours healthy tissue preservation while accompanying increased toxicity toward cancer cells. Cytotoxicity results are well correlated with theoretical modelling and release study, providing promising results for applicative purposes.", publisher = "MDPI", journal = "Journal of Functional Biomaterials", title = "Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?", volume = "14", number = "3", doi = "10.3390/jfb14030173" }
Ranković, M., Jevremović, A., Janošević-Ležaić, A., Arsenijević, A., Rupar, J., Dobričić, V., Nedić Vasiljević, B., Gavrilov, N., Bajuk-Bogdanović, D.,& Milojević-Rakić, M.. (2023). Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?. in Journal of Functional Biomaterials MDPI., 14(3). https://doi.org/10.3390/jfb14030173
Ranković M, Jevremović A, Janošević-Ležaić A, Arsenijević A, Rupar J, Dobričić V, Nedić Vasiljević B, Gavrilov N, Bajuk-Bogdanović D, Milojević-Rakić M. Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?. in Journal of Functional Biomaterials. 2023;14(3). doi:10.3390/jfb14030173 .
Ranković, Maja, Jevremović, Anka, Janošević-Ležaić, Aleksandra, Arsenijević, Aleksandar, Rupar, Jelena, Dobričić, Vladimir, Nedić Vasiljević, Bojana, Gavrilov, Nemanja, Bajuk-Bogdanović, Danica, Milojević-Rakić, Maja, "Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?" in Journal of Functional Biomaterials, 14, no. 3 (2023), https://doi.org/10.3390/jfb14030173 . .