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The phenotype of Graves’ orbitopathy is associated with thyrotropin receptor antibody levels
dc.creator | Sarić-Matutinović, Marija | |
dc.creator | Kahaly, G.J. | |
dc.creator | Žarković, Miloš | |
dc.creator | Ćirić, J. | |
dc.creator | Ignjatović, Svetlana | |
dc.creator | Nedeljković Beleslin, B. | |
dc.date.accessioned | 2023-04-18T09:00:49Z | |
dc.date.available | 2023-04-18T09:00:49Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0391-4097 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/4654 | |
dc.description.abstract | Purpose: Graves’ orbitopathy (GO) is a specific inflammatory disorder of the orbit characterized by a highly heterogeneous clinical phenotype. The role of thyrotropin receptor antibodies (TSH-R-Ab) has been widely researched, however there is still no evidence that these antibodies have a direct pathogenic role in this pathology. The aim of this study was to examine their relation to the individual clinical features of GO. Methods: Ninety-one consecutive patients with GO were recruited. Total antibody concentration (TSH-R binding inhibitory immunoglobulins, TBII) and their functional activity (stimulating TSH-R-Ab, TSAb) were measured using binding immunoassay and cell-based bioassay, respectively. Results: Both TSAb and TBII levels were significantly associated to the clinical parameters of GO activity. TSAb was a more sensitive serological marker compared to TBII pertaining to eyelid retraction and edema, proptosis, extra-orbital muscle disorders, diplopia, irritable eye symptoms, and photophobia. TSAb, but not TBII, was a significant predictive marker of conjunctival redness, chemosis, caruncle/plica inflammation, eye irritation, and orbital pain, (odds ratio: 3.096, p = 0.016; 5.833, p = 0.009; 6.443, p = 0.020; 3.167, p = 0.045; 2.893, p = 0.032; versus 2.187, p = 0.093; 2.775, p = 0.081; 3.824, p = 0.055; 0.952, p = 0.930; 2.226, p = 0.099, respectively). Neither TSAb nor TBII correlated with the level of proptosis (ρ = 0.259, p = 0.090, and ρ = 0.254, p = 0.104, respectively), however rising TSAb levels were strongly associated to the level of proptosis. Conclusions: TSH-R-Ab were significantly associated with GO’s phenotype. Especially TSAb, as a sensitive and predictive serological biomarker, can improve diagnosis and management of GO. | |
dc.publisher | Springer Science and Business Media | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Endocrinological Investigation | |
dc.subject | Binding immunoassay | |
dc.subject | Cell-based bioassay | |
dc.subject | Graves’ orbitopathy | |
dc.subject | Ophthalmological features | |
dc.subject | Stimulating antibodies | |
dc.subject | Thyrotropin receptor antibodies | |
dc.title | The phenotype of Graves’ orbitopathy is associated with thyrotropin receptor antibody levels | |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.rank | M21~ | |
dc.identifier.wos | 000963641400002 | |
dc.identifier.doi | 10.1007/s40618-023-02085-5 | |
dc.identifier.pmid | 37020104 | |
dc.identifier.scopus | 2-s2.0-85151504022 | |
dc.type.version | publishedVersion |