Cadmium and lead implication in testis cancer; is there a connection?
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2023
Authors
Anđelković, Milena
Buha-Đorđević, Aleksandra

Vukelić, Dragana

Đukić-Ćosić, Danijela

Aćimović, Miodrag
Bojanić, Nebojša
Bartolović, Daniela
Bulat, Petar

Antonijević, Biljana

Bulat, Zorica

Article (Published version)

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Testis cancer (TC) is the most common malignancy of young men. Current evidence from studies, alongside genetics and hormonal status, suggests a significant role of toxic metals, cadmium (Cd) and lead (Pb), in the origin and development of TC. Besides oxidative stress and endocrine disruption, interaction with bioelements is one of the critical mechanisms of Cd and Pb toxicity and malign transformation. This study aimed to investigate metal levels in blood, healthy, and tumor testis tissue and to reveal hormone, oxidative status, and bioelements levels in patients with TC. The study enrolled 52 patients with TC and 61 healthy volunteers. Toxic metals and bioelements levels were analyzed by atomic absorption spectrophotometry (AAS) while electrochemiluminescence immunoassay (ECLIA) and spectrophotometry methods were used for hormone and oxidative parameters evaluation. Significantly higher blood Cd levels were depicted in TC cohort. Furthermore, blood Cd elevation was associated with a ...1.98 higher probability of TC developing. However, a metal concentration between healthy and tumor testis tissue did not differ significantly. Lower levels of estradiol and testosterone, established in a cohort of TC patients, followed the significant role of hormones in TC development. At the same time, ischemia-modified albumin (IMA) has been recognized as a parameter with very good accuracy as a potential diagnostic marker for TC. The study revealed different distribution patterns of copper (Cu) and zinc (Zn) in the three compartments of the patients, as well significant correlation between essential metals Cu/Zn and toxic metals Cd/Pb indicating metal-metal interactions as pivotal mechanisms of metals toxicity.
Keywords:
Bioelements / Cadmium / Oxidative status / Lead / Testis cancerSource:
Chemosphere, 2023, 330Publisher:
- Elsevier Ltd
Funding / projects:
DOI: 10.1016/j.chemosphere.2023.138698
ISSN: 0045-6535
PubMed: 37062390
WoS: 000984816600001
Scopus: 2-s2.0-85152716399
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PharmacyTY - JOUR AU - Anđelković, Milena AU - Buha-Đorđević, Aleksandra AU - Vukelić, Dragana AU - Đukić-Ćosić, Danijela AU - Aćimović, Miodrag AU - Bojanić, Nebojša AU - Bartolović, Daniela AU - Bulat, Petar AU - Antonijević, Biljana AU - Bulat, Zorica PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4675 AB - Testis cancer (TC) is the most common malignancy of young men. Current evidence from studies, alongside genetics and hormonal status, suggests a significant role of toxic metals, cadmium (Cd) and lead (Pb), in the origin and development of TC. Besides oxidative stress and endocrine disruption, interaction with bioelements is one of the critical mechanisms of Cd and Pb toxicity and malign transformation. This study aimed to investigate metal levels in blood, healthy, and tumor testis tissue and to reveal hormone, oxidative status, and bioelements levels in patients with TC. The study enrolled 52 patients with TC and 61 healthy volunteers. Toxic metals and bioelements levels were analyzed by atomic absorption spectrophotometry (AAS) while electrochemiluminescence immunoassay (ECLIA) and spectrophotometry methods were used for hormone and oxidative parameters evaluation. Significantly higher blood Cd levels were depicted in TC cohort. Furthermore, blood Cd elevation was associated with a 1.98 higher probability of TC developing. However, a metal concentration between healthy and tumor testis tissue did not differ significantly. Lower levels of estradiol and testosterone, established in a cohort of TC patients, followed the significant role of hormones in TC development. At the same time, ischemia-modified albumin (IMA) has been recognized as a parameter with very good accuracy as a potential diagnostic marker for TC. The study revealed different distribution patterns of copper (Cu) and zinc (Zn) in the three compartments of the patients, as well significant correlation between essential metals Cu/Zn and toxic metals Cd/Pb indicating metal-metal interactions as pivotal mechanisms of metals toxicity. PB - Elsevier Ltd T2 - Chemosphere T1 - Cadmium and lead implication in testis cancer; is there a connection? VL - 330 DO - 10.1016/j.chemosphere.2023.138698 ER -
@article{ author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Vukelić, Dragana and Đukić-Ćosić, Danijela and Aćimović, Miodrag and Bojanić, Nebojša and Bartolović, Daniela and Bulat, Petar and Antonijević, Biljana and Bulat, Zorica", year = "2023", abstract = "Testis cancer (TC) is the most common malignancy of young men. Current evidence from studies, alongside genetics and hormonal status, suggests a significant role of toxic metals, cadmium (Cd) and lead (Pb), in the origin and development of TC. Besides oxidative stress and endocrine disruption, interaction with bioelements is one of the critical mechanisms of Cd and Pb toxicity and malign transformation. This study aimed to investigate metal levels in blood, healthy, and tumor testis tissue and to reveal hormone, oxidative status, and bioelements levels in patients with TC. The study enrolled 52 patients with TC and 61 healthy volunteers. Toxic metals and bioelements levels were analyzed by atomic absorption spectrophotometry (AAS) while electrochemiluminescence immunoassay (ECLIA) and spectrophotometry methods were used for hormone and oxidative parameters evaluation. Significantly higher blood Cd levels were depicted in TC cohort. Furthermore, blood Cd elevation was associated with a 1.98 higher probability of TC developing. However, a metal concentration between healthy and tumor testis tissue did not differ significantly. Lower levels of estradiol and testosterone, established in a cohort of TC patients, followed the significant role of hormones in TC development. At the same time, ischemia-modified albumin (IMA) has been recognized as a parameter with very good accuracy as a potential diagnostic marker for TC. The study revealed different distribution patterns of copper (Cu) and zinc (Zn) in the three compartments of the patients, as well significant correlation between essential metals Cu/Zn and toxic metals Cd/Pb indicating metal-metal interactions as pivotal mechanisms of metals toxicity.", publisher = "Elsevier Ltd", journal = "Chemosphere", title = "Cadmium and lead implication in testis cancer; is there a connection?", volume = "330", doi = "10.1016/j.chemosphere.2023.138698" }
Anđelković, M., Buha-Đorđević, A., Vukelić, D., Đukić-Ćosić, D., Aćimović, M., Bojanić, N., Bartolović, D., Bulat, P., Antonijević, B.,& Bulat, Z.. (2023). Cadmium and lead implication in testis cancer; is there a connection?. in Chemosphere Elsevier Ltd., 330. https://doi.org/10.1016/j.chemosphere.2023.138698
Anđelković M, Buha-Đorđević A, Vukelić D, Đukić-Ćosić D, Aćimović M, Bojanić N, Bartolović D, Bulat P, Antonijević B, Bulat Z. Cadmium and lead implication in testis cancer; is there a connection?. in Chemosphere. 2023;330. doi:10.1016/j.chemosphere.2023.138698 .
Anđelković, Milena, Buha-Đorđević, Aleksandra, Vukelić, Dragana, Đukić-Ćosić, Danijela, Aćimović, Miodrag, Bojanić, Nebojša, Bartolović, Daniela, Bulat, Petar, Antonijević, Biljana, Bulat, Zorica, "Cadmium and lead implication in testis cancer; is there a connection?" in Chemosphere, 330 (2023), https://doi.org/10.1016/j.chemosphere.2023.138698 . .