The apparent ionization constants (pKa*) of raloxifene have been determined potentiometrically in methanol water mixtures (45% - 55% wt/wt) and the pKa values (pKa1=7.21±0.02, pKa2=7.86±0.02, pKa3=9.97±0.04) which define the ionization in aqueous media were obtained by extrapolation of the pKa* values to 0% of methanol. Obtained pKa values were assigned to corresponding ionization centers. On the basis of the ionization constants determined in this study distribution of raloxifene equilibrium forms have been calculated.
TY - CONF
AU - Popović-Nikolić, Marija
AU - Čakar, Mira
AU - Popović, Gordana
PY - 2022
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4682
AB - The apparent ionization constants (pKa*) of raloxifene have been determined potentiometrically in methanol water mixtures (45% - 55% wt/wt) and the pKa values (pKa1=7.21±0.02, pKa2=7.86±0.02, pKa3=9.97±0.04) which define the ionization in aqueous media were obtained by extrapolation of the pKa* values to 0% of methanol. Obtained pKa values were assigned to corresponding ionization centers. On the basis of the ionization constants determined in this study distribution of raloxifene equilibrium forms have been calculated.
PB - Society of Physical Chemists of Serbia
C3 - PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
T1 - The protolytic equilibria of raloxifene
VL - II
SP - 581
EP - 584
UR - https://hdl.handle.net/21.15107/rcub_farfar_4682
ER -
@conference{
author = "Popović-Nikolić, Marija and Čakar, Mira and Popović, Gordana",
year = "2022",
abstract = "The apparent ionization constants (pKa*) of raloxifene have been determined potentiometrically in methanol water mixtures (45% - 55% wt/wt) and the pKa values (pKa1=7.21±0.02, pKa2=7.86±0.02, pKa3=9.97±0.04) which define the ionization in aqueous media were obtained by extrapolation of the pKa* values to 0% of methanol. Obtained pKa values were assigned to corresponding ionization centers. On the basis of the ionization constants determined in this study distribution of raloxifene equilibrium forms have been calculated.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)",
title = "The protolytic equilibria of raloxifene",
volume = "II",
pages = "581-584",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4682"
}
Popović-Nikolić, M., Čakar, M.,& Popović, G.. (2022). The protolytic equilibria of raloxifene. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)
Society of Physical Chemists of Serbia., II, 581-584.
https://hdl.handle.net/21.15107/rcub_farfar_4682
Popović-Nikolić M, Čakar M, Popović G. The protolytic equilibria of raloxifene. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings). 2022;II:581-584.
https://hdl.handle.net/21.15107/rcub_farfar_4682 .
Popović-Nikolić, Marija, Čakar, Mira, Popović, Gordana, "The protolytic equilibria of raloxifene" in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings), II (2022):581-584,
https://hdl.handle.net/21.15107/rcub_farfar_4682 .
