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Fosinopril-sodium and its degradation product analysis in Monopril® tablets

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2003
Fosinopril_sodium_and_pub_2003.pdf (115.8Kb)
Authors
Jančić, Biljana
Ivanović, Darko
Medenica, Mirjana
Malenović, Anđelija
Conference object (Published version)
Metadata
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Abstract
The reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of fosinopril-sodium and its degradation product in Monopril® tablets. The chromatographic system Hewlett Packard 1100 consisted era HP 1100 pump, HP 1100 UV-VIS detector and HP ChemStation integrator. Separations were performed on the X Terra™ 150 mm x 4.6 mm, 5 μm particle column at 45 °C. The samples were introduced through a Rheodyne injector valve with a 20 μL sample loop. Methanol-water (75:25 V/V) was used as a mobile phase, with flow rate 1 mL/min. pH was adjusted to 3.1 with ortophosphoric acid. UV detection was performed at 220 nm. Propylparaben was used as an internal standard. The results obtained showed a good agreement with the declared contents. Recovery values for fosinoprit-sodium were from 101.6% to 102.9%. Content of degradation product SQ 27519 was lower than 5%. The proposed method is rapid, accurate, selective and because of its sensiti...vity and reproducibility, it may be used for the quantitative analysis of fosinopril-sodium and its degradation product in Monopril® tablets.

Keywords:
Degradation product / Fosinopril-sodium / RP-HPLC
Source:
Acta Chimica Slovenica, 2003, 50, 2, 327-333
Publisher:
  • Slovensko Kemijsko Drustvo

ISSN: 1318-0207

WoS: 000183528400014

Scopus: 2-s2.0-0038161145
[ Google Scholar ]
5
Handle
https://hdl.handle.net/21.15107/rcub_farfar_473
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/473
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - CONF
AU  - Jančić, Biljana
AU  - Ivanović, Darko
AU  - Medenica, Mirjana
AU  - Malenović, Anđelija
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/473
AB  - The reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of fosinopril-sodium and its degradation product in Monopril® tablets. The chromatographic system Hewlett Packard 1100 consisted era HP 1100 pump, HP 1100 UV-VIS detector and HP ChemStation integrator. Separations were performed on the X Terra™ 150 mm x 4.6 mm, 5 μm particle column at 45 °C. The samples were introduced through a Rheodyne injector valve with a 20 μL sample loop. Methanol-water (75:25 V/V) was used as a mobile phase, with flow rate 1 mL/min. pH was adjusted to 3.1 with ortophosphoric acid. UV detection was performed at 220 nm. Propylparaben was used as an internal standard. The results obtained showed a good agreement with the declared contents. Recovery values for fosinoprit-sodium were from 101.6% to 102.9%. Content of degradation product SQ 27519 was lower than 5%. The proposed method is rapid, accurate, selective and because of its sensitivity and reproducibility, it may be used for the quantitative analysis of fosinopril-sodium and its degradation product in Monopril® tablets.
PB  - Slovensko Kemijsko Drustvo
C3  - Acta Chimica Slovenica
T1  - Fosinopril-sodium and its degradation product analysis in Monopril® tablets
VL  - 50
IS  - 2
SP  - 327
EP  - 333
UR  - https://hdl.handle.net/21.15107/rcub_farfar_473
ER  - 
@conference{
author = "Jančić, Biljana and Ivanović, Darko and Medenica, Mirjana and Malenović, Anđelija",
year = "2003",
abstract = "The reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of fosinopril-sodium and its degradation product in Monopril® tablets. The chromatographic system Hewlett Packard 1100 consisted era HP 1100 pump, HP 1100 UV-VIS detector and HP ChemStation integrator. Separations were performed on the X Terra™ 150 mm x 4.6 mm, 5 μm particle column at 45 °C. The samples were introduced through a Rheodyne injector valve with a 20 μL sample loop. Methanol-water (75:25 V/V) was used as a mobile phase, with flow rate 1 mL/min. pH was adjusted to 3.1 with ortophosphoric acid. UV detection was performed at 220 nm. Propylparaben was used as an internal standard. The results obtained showed a good agreement with the declared contents. Recovery values for fosinoprit-sodium were from 101.6% to 102.9%. Content of degradation product SQ 27519 was lower than 5%. The proposed method is rapid, accurate, selective and because of its sensitivity and reproducibility, it may be used for the quantitative analysis of fosinopril-sodium and its degradation product in Monopril® tablets.",
publisher = "Slovensko Kemijsko Drustvo",
journal = "Acta Chimica Slovenica",
title = "Fosinopril-sodium and its degradation product analysis in Monopril® tablets",
volume = "50",
number = "2",
pages = "327-333",
url = "https://hdl.handle.net/21.15107/rcub_farfar_473"
}
Jančić, B., Ivanović, D., Medenica, M.,& Malenović, A.. (2003). Fosinopril-sodium and its degradation product analysis in Monopril® tablets. in Acta Chimica Slovenica
Slovensko Kemijsko Drustvo., 50(2), 327-333.
https://hdl.handle.net/21.15107/rcub_farfar_473
Jančić B, Ivanović D, Medenica M, Malenović A. Fosinopril-sodium and its degradation product analysis in Monopril® tablets. in Acta Chimica Slovenica. 2003;50(2):327-333.
https://hdl.handle.net/21.15107/rcub_farfar_473 .
Jančić, Biljana, Ivanović, Darko, Medenica, Mirjana, Malenović, Anđelija, "Fosinopril-sodium and its degradation product analysis in Monopril® tablets" in Acta Chimica Slovenica, 50, no. 2 (2003):327-333,
https://hdl.handle.net/21.15107/rcub_farfar_473 .

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