Computer-aided drug design and evaluation of selective inhibitors against cytoplasmic histone deacetylases
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2022
Authors
Ružić, Dušan
Đoković, Nemanja

Petković, Miloš

Gul, Sheraz

Lahtela‐Kakkonen, Maija
Ganesan, A.
Nikolić, Katarina

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The influence of histone posttranslational modifications on gene expression is one of the most examined
epigenetic processes. One of the epigenetic enzymes with crucial role in histone posttranslational modifications
are histone deacetylases (HDACs). The alteration in the structure and function of HDACs isoforms are related to
the pathogenesis of cancer, inflammation and neurodegeneration1-3. With different tissue distribution and cellular function the HDACs are defined as crucial drug targets.
Source:
37th ACS National Medicinal Chemistry Symposium - American Chemical Society Division of Medicinal Chemistry, Book of Abstracts, 26-06-2022, P47, -125Publisher:
- American Chemical Society Division of Medicinal Chemistry
Funding / projects:
Note:
- 37th ACS National Medicinal Chemistry Symposium - American Chemical Society Division of Medicinal Chemistry
URI
https://www.rsc.org/events/detail/73101/37th-acs-national-medicinal-chemistry-symposium-american-chemical-society-division-of-medicinal-chemistryhttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4739
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PharmacyTY - CONF AU - Ružić, Dušan AU - Đoković, Nemanja AU - Petković, Miloš AU - Gul, Sheraz AU - Lahtela‐Kakkonen, Maija AU - Ganesan, A. AU - Nikolić, Katarina PY - 2022-06-26 UR - https://www.rsc.org/events/detail/73101/37th-acs-national-medicinal-chemistry-symposium-american-chemical-society-division-of-medicinal-chemistry UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4739 AB - The influence of histone posttranslational modifications on gene expression is one of the most examined epigenetic processes. One of the epigenetic enzymes with crucial role in histone posttranslational modifications are histone deacetylases (HDACs). The alteration in the structure and function of HDACs isoforms are related to the pathogenesis of cancer, inflammation and neurodegeneration1-3. With different tissue distribution and cellular function the HDACs are defined as crucial drug targets. PB - American Chemical Society Division of Medicinal Chemistry C3 - 37th ACS National Medicinal Chemistry Symposium - American Chemical Society Division of Medicinal Chemistry, Book of Abstracts T1 - Computer-aided drug design and evaluation of selective inhibitors against cytoplasmic histone deacetylases IS - P47 EP - 125 UR - https://hdl.handle.net/21.15107/rcub_farfar_4739 ER -
@conference{ author = "Ružić, Dušan and Đoković, Nemanja and Petković, Miloš and Gul, Sheraz and Lahtela‐Kakkonen, Maija and Ganesan, A. and Nikolić, Katarina", year = "2022-06-26", abstract = "The influence of histone posttranslational modifications on gene expression is one of the most examined epigenetic processes. One of the epigenetic enzymes with crucial role in histone posttranslational modifications are histone deacetylases (HDACs). The alteration in the structure and function of HDACs isoforms are related to the pathogenesis of cancer, inflammation and neurodegeneration1-3. With different tissue distribution and cellular function the HDACs are defined as crucial drug targets.", publisher = "American Chemical Society Division of Medicinal Chemistry", journal = "37th ACS National Medicinal Chemistry Symposium - American Chemical Society Division of Medicinal Chemistry, Book of Abstracts", title = "Computer-aided drug design and evaluation of selective inhibitors against cytoplasmic histone deacetylases", number = "P47", pages = "125", url = "https://hdl.handle.net/21.15107/rcub_farfar_4739" }
Ružić, D., Đoković, N., Petković, M., Gul, S., Lahtela‐Kakkonen, M., Ganesan, A.,& Nikolić, K.. (2022-06-26). Computer-aided drug design and evaluation of selective inhibitors against cytoplasmic histone deacetylases. in 37th ACS National Medicinal Chemistry Symposium - American Chemical Society Division of Medicinal Chemistry, Book of Abstracts American Chemical Society Division of Medicinal Chemistry.(P47). https://hdl.handle.net/21.15107/rcub_farfar_4739
Ružić D, Đoković N, Petković M, Gul S, Lahtela‐Kakkonen M, Ganesan A, Nikolić K. Computer-aided drug design and evaluation of selective inhibitors against cytoplasmic histone deacetylases. in 37th ACS National Medicinal Chemistry Symposium - American Chemical Society Division of Medicinal Chemistry, Book of Abstracts. 2022;(P47):null-125. https://hdl.handle.net/21.15107/rcub_farfar_4739 .
Ružić, Dušan, Đoković, Nemanja, Petković, Miloš, Gul, Sheraz, Lahtela‐Kakkonen, Maija, Ganesan, A., Nikolić, Katarina, "Computer-aided drug design and evaluation of selective inhibitors against cytoplasmic histone deacetylases" in 37th ACS National Medicinal Chemistry Symposium - American Chemical Society Division of Medicinal Chemistry, Book of Abstracts, no. P47 (2022-06-26), https://hdl.handle.net/21.15107/rcub_farfar_4739 .