Fosinopril-sodium and its degradation product analysis in Monopril® tablets
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The reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of fosinopril-sodium and its degradation product in Monopril® tablets. The chromatographic system Hewlett Packard 1100 consisted era HP 1100 pump, HP 1100 UV-VIS detector and HP ChemStation integrator. Separations were performed on the X Terra™ 150 mm x 4.6 mm, 5 μm particle column at 45 °C. The samples were introduced through a Rheodyne injector valve with a 20 μL sample loop. Methanol-water (75:25 V/V) was used as a mobile phase, with flow rate 1 mL/min. pH was adjusted to 3.1 with ortophosphoric acid. UV detection was performed at 220 nm. Propylparaben was used as an internal standard. The results obtained showed a good agreement with the declared contents. Recovery values for fosinoprit-sodium were from 101.6% to 102.9%. Content of degradation product SQ 27519 was lower than 5%. The proposed method is rapid, accurate, selective and because of its sensiti...vity and reproducibility, it may be used for the quantitative analysis of fosinopril-sodium and its degradation product in Monopril® tablets.
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Degradation product / Fosinopril-sodium / RP-HPLCSource:
Acta Chimica Slovenica, 2003, 50, 2, 327-333Publisher:
- Slovensko Kemijsko Drustvo
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PharmacyTY - CONF AU - Jančić, Biljana AU - Ivanović, Darko AU - Medenica, Mirjana AU - Malenović, Anđelija PY - 2003 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/473 AB - The reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of fosinopril-sodium and its degradation product in Monopril® tablets. The chromatographic system Hewlett Packard 1100 consisted era HP 1100 pump, HP 1100 UV-VIS detector and HP ChemStation integrator. Separations were performed on the X Terra™ 150 mm x 4.6 mm, 5 μm particle column at 45 °C. The samples were introduced through a Rheodyne injector valve with a 20 μL sample loop. Methanol-water (75:25 V/V) was used as a mobile phase, with flow rate 1 mL/min. pH was adjusted to 3.1 with ortophosphoric acid. UV detection was performed at 220 nm. Propylparaben was used as an internal standard. The results obtained showed a good agreement with the declared contents. Recovery values for fosinoprit-sodium were from 101.6% to 102.9%. Content of degradation product SQ 27519 was lower than 5%. The proposed method is rapid, accurate, selective and because of its sensitivity and reproducibility, it may be used for the quantitative analysis of fosinopril-sodium and its degradation product in Monopril® tablets. PB - Slovensko Kemijsko Drustvo C3 - Acta Chimica Slovenica T1 - Fosinopril-sodium and its degradation product analysis in Monopril® tablets VL - 50 IS - 2 SP - 327 EP - 333 UR - https://hdl.handle.net/21.15107/rcub_farfar_473 ER -
@conference{ author = "Jančić, Biljana and Ivanović, Darko and Medenica, Mirjana and Malenović, Anđelija", year = "2003", abstract = "The reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of fosinopril-sodium and its degradation product in Monopril® tablets. The chromatographic system Hewlett Packard 1100 consisted era HP 1100 pump, HP 1100 UV-VIS detector and HP ChemStation integrator. Separations were performed on the X Terra™ 150 mm x 4.6 mm, 5 μm particle column at 45 °C. The samples were introduced through a Rheodyne injector valve with a 20 μL sample loop. Methanol-water (75:25 V/V) was used as a mobile phase, with flow rate 1 mL/min. pH was adjusted to 3.1 with ortophosphoric acid. UV detection was performed at 220 nm. Propylparaben was used as an internal standard. The results obtained showed a good agreement with the declared contents. Recovery values for fosinoprit-sodium were from 101.6% to 102.9%. Content of degradation product SQ 27519 was lower than 5%. The proposed method is rapid, accurate, selective and because of its sensitivity and reproducibility, it may be used for the quantitative analysis of fosinopril-sodium and its degradation product in Monopril® tablets.", publisher = "Slovensko Kemijsko Drustvo", journal = "Acta Chimica Slovenica", title = "Fosinopril-sodium and its degradation product analysis in Monopril® tablets", volume = "50", number = "2", pages = "327-333", url = "https://hdl.handle.net/21.15107/rcub_farfar_473" }
Jančić, B., Ivanović, D., Medenica, M.,& Malenović, A.. (2003). Fosinopril-sodium and its degradation product analysis in Monopril® tablets. in Acta Chimica Slovenica Slovensko Kemijsko Drustvo., 50(2), 327-333. https://hdl.handle.net/21.15107/rcub_farfar_473
Jančić B, Ivanović D, Medenica M, Malenović A. Fosinopril-sodium and its degradation product analysis in Monopril® tablets. in Acta Chimica Slovenica. 2003;50(2):327-333. https://hdl.handle.net/21.15107/rcub_farfar_473 .
Jančić, Biljana, Ivanović, Darko, Medenica, Mirjana, Malenović, Anđelija, "Fosinopril-sodium and its degradation product analysis in Monopril® tablets" in Acta Chimica Slovenica, 50, no. 2 (2003):327-333, https://hdl.handle.net/21.15107/rcub_farfar_473 .