dc.creator | Jančić, Biljana | |
dc.creator | Ivanović, Darko | |
dc.creator | Medenica, Mirjana | |
dc.creator | Malenović, Anđelija | |
dc.date.accessioned | 2019-09-02T10:58:00Z | |
dc.date.available | 2019-09-02T10:58:00Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 1318-0207 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/473 | |
dc.description.abstract | The reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of fosinopril-sodium and its degradation product in Monopril® tablets. The chromatographic system Hewlett Packard 1100 consisted era HP 1100 pump, HP 1100 UV-VIS detector and HP ChemStation integrator. Separations were performed on the X Terra™ 150 mm x 4.6 mm, 5 μm particle column at 45 °C. The samples were introduced through a Rheodyne injector valve with a 20 μL sample loop. Methanol-water (75:25 V/V) was used as a mobile phase, with flow rate 1 mL/min. pH was adjusted to 3.1 with ortophosphoric acid. UV detection was performed at 220 nm. Propylparaben was used as an internal standard. The results obtained showed a good agreement with the declared contents. Recovery values for fosinoprit-sodium were from 101.6% to 102.9%. Content of degradation product SQ 27519 was lower than 5%. The proposed method is rapid, accurate, selective and because of its sensitivity and reproducibility, it may be used for the quantitative analysis of fosinopril-sodium and its degradation product in Monopril® tablets. | en |
dc.publisher | Slovensko Kemijsko Drustvo | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Acta Chimica Slovenica | |
dc.subject | Degradation product | en |
dc.subject | Fosinopril-sodium | en |
dc.subject | RP-HPLC | en |
dc.title | Fosinopril-sodium and its degradation product analysis in Monopril® tablets | en |
dc.type | conferenceObject | |
dc.rights.license | BY | |
dcterms.abstract | Јанчић, Биљана; Меденица, Мирјана; Маленовић, Aнђелија; Ивановић, Д; | |
dc.citation.volume | 50 | |
dc.citation.issue | 2 | |
dc.citation.spage | 327 | |
dc.citation.epage | 333 | |
dc.citation.other | 50(2): 327-333 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000183528400014 | |
dc.identifier.scopus | 2-s2.0-0038161145 | |
dc.identifier.fulltext | http://farfar.pharmacy.bg.ac.rs/bitstream/id/10590/Fosinopril_sodium_and_pub_2003.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_473 | |
dc.type.version | publishedVersion | |