Evaluation of antioxidative, antigenotoxic, and anticancer activities of commercial medical mushrooms products: Agaricus blazei, Cordyceps Sinensis and Immune Assist
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Mushrooms have been evaluated for their nutritional and medicinal properties for
centuries. We evaluated the biological activities of commercial products of Cordyceps
Sinensis (CS), Agaricus blazei (AB), and Immune Assist (IA) (all produced by Aloha
Medicinals). Immune Assist (IA) is made from extract of six species of medical
mushrooms: Agaricus blazei - Cordycepssinensis - Grifola frondosa - Ganoderma
lucidum - Coriolus versicolor - Lentinula edodes.
The antioxidant evaluation showed that CS had strong OH scavenging properties and
moderate reducing power, while its DPPH scavenging ability was weak. AB displayed
remarkable ·OH scavenging properties, moderate reducing power, and modest DPPH
scavenging activity, similar to IA. Also, CS, AB and IA displayed significant antigenotoxic
effects in human peripheral blood cells against H2O2-induced DNA damage.
Further, the cytotoxicity of CS, AB, and IA to HS-5 (bone marrow stroma cells), MCF-
7 (human breast epithelial cell line),... and MDA-MB-231 (human breast carcinoma cell
line) were assessed using MTT assay. AB and IA could inhibit the proliferative action
of mentioned cancer cell lines after 72h in a dose-dependent manner, while there were
no effects on HS-5 cell lines proliferation, while CS did not show anti-proliferative/
cytotoxic activity on cancer cell lines.
Current findings remain a significant challenge for the usage of medicinal mushrooms
in the field of cancer prevention/treatment, and thus an active area of future research.
Keywords:
Medical mushrooms / antioxidative properties / antigenotoxicity / cytotoxicitySource:
51st EEMGS and 27th SEMA meeting: Abstract book, 2023, 46-46Publisher:
- European Environmental Mutagenesis and Genomics Society (EEMGS)
Funding / projects:
Note:
- dodati broj ugovora za Institut Vinča
- 51st European Environmental Mutagenesis and Genomics Society (EEMGS) & 27th Spanish Environmental Mutagenesis and Genomics Society (SEMA) meeting, May 15th- 18th, 2023
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PharmacyTY - CONF AU - Živković, Lada AU - Borozan, Sunčica AU - Topalović, Dijana AU - Bajić, Vladan AU - Spremo-Potparević, Biljana PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4748 AB - Mushrooms have been evaluated for their nutritional and medicinal properties for centuries. We evaluated the biological activities of commercial products of Cordyceps Sinensis (CS), Agaricus blazei (AB), and Immune Assist (IA) (all produced by Aloha Medicinals). Immune Assist (IA) is made from extract of six species of medical mushrooms: Agaricus blazei - Cordycepssinensis - Grifola frondosa - Ganoderma lucidum - Coriolus versicolor - Lentinula edodes. The antioxidant evaluation showed that CS had strong OH scavenging properties and moderate reducing power, while its DPPH scavenging ability was weak. AB displayed remarkable ·OH scavenging properties, moderate reducing power, and modest DPPH scavenging activity, similar to IA. Also, CS, AB and IA displayed significant antigenotoxic effects in human peripheral blood cells against H2O2-induced DNA damage. Further, the cytotoxicity of CS, AB, and IA to HS-5 (bone marrow stroma cells), MCF- 7 (human breast epithelial cell line), and MDA-MB-231 (human breast carcinoma cell line) were assessed using MTT assay. AB and IA could inhibit the proliferative action of mentioned cancer cell lines after 72h in a dose-dependent manner, while there were no effects on HS-5 cell lines proliferation, while CS did not show anti-proliferative/ cytotoxic activity on cancer cell lines. Current findings remain a significant challenge for the usage of medicinal mushrooms in the field of cancer prevention/treatment, and thus an active area of future research. PB - European Environmental Mutagenesis and Genomics Society (EEMGS) C3 - 51st EEMGS and 27th SEMA meeting: Abstract book T1 - Evaluation of antioxidative, antigenotoxic, and anticancer activities of commercial medical mushrooms products: Agaricus blazei, Cordyceps Sinensis and Immune Assist SP - 46 EP - 46 UR - https://hdl.handle.net/21.15107/rcub_farfar_4748 ER -
@conference{ author = "Živković, Lada and Borozan, Sunčica and Topalović, Dijana and Bajić, Vladan and Spremo-Potparević, Biljana", year = "2023", abstract = "Mushrooms have been evaluated for their nutritional and medicinal properties for centuries. We evaluated the biological activities of commercial products of Cordyceps Sinensis (CS), Agaricus blazei (AB), and Immune Assist (IA) (all produced by Aloha Medicinals). Immune Assist (IA) is made from extract of six species of medical mushrooms: Agaricus blazei - Cordycepssinensis - Grifola frondosa - Ganoderma lucidum - Coriolus versicolor - Lentinula edodes. The antioxidant evaluation showed that CS had strong OH scavenging properties and moderate reducing power, while its DPPH scavenging ability was weak. AB displayed remarkable ·OH scavenging properties, moderate reducing power, and modest DPPH scavenging activity, similar to IA. Also, CS, AB and IA displayed significant antigenotoxic effects in human peripheral blood cells against H2O2-induced DNA damage. Further, the cytotoxicity of CS, AB, and IA to HS-5 (bone marrow stroma cells), MCF- 7 (human breast epithelial cell line), and MDA-MB-231 (human breast carcinoma cell line) were assessed using MTT assay. AB and IA could inhibit the proliferative action of mentioned cancer cell lines after 72h in a dose-dependent manner, while there were no effects on HS-5 cell lines proliferation, while CS did not show anti-proliferative/ cytotoxic activity on cancer cell lines. Current findings remain a significant challenge for the usage of medicinal mushrooms in the field of cancer prevention/treatment, and thus an active area of future research.", publisher = "European Environmental Mutagenesis and Genomics Society (EEMGS)", journal = "51st EEMGS and 27th SEMA meeting: Abstract book", title = "Evaluation of antioxidative, antigenotoxic, and anticancer activities of commercial medical mushrooms products: Agaricus blazei, Cordyceps Sinensis and Immune Assist", pages = "46-46", url = "https://hdl.handle.net/21.15107/rcub_farfar_4748" }
Živković, L., Borozan, S., Topalović, D., Bajić, V.,& Spremo-Potparević, B.. (2023). Evaluation of antioxidative, antigenotoxic, and anticancer activities of commercial medical mushrooms products: Agaricus blazei, Cordyceps Sinensis and Immune Assist. in 51st EEMGS and 27th SEMA meeting: Abstract book European Environmental Mutagenesis and Genomics Society (EEMGS)., 46-46. https://hdl.handle.net/21.15107/rcub_farfar_4748
Živković L, Borozan S, Topalović D, Bajić V, Spremo-Potparević B. Evaluation of antioxidative, antigenotoxic, and anticancer activities of commercial medical mushrooms products: Agaricus blazei, Cordyceps Sinensis and Immune Assist. in 51st EEMGS and 27th SEMA meeting: Abstract book. 2023;:46-46. https://hdl.handle.net/21.15107/rcub_farfar_4748 .
Živković, Lada, Borozan, Sunčica, Topalović, Dijana, Bajić, Vladan, Spremo-Potparević, Biljana, "Evaluation of antioxidative, antigenotoxic, and anticancer activities of commercial medical mushrooms products: Agaricus blazei, Cordyceps Sinensis and Immune Assist" in 51st EEMGS and 27th SEMA meeting: Abstract book (2023):46-46, https://hdl.handle.net/21.15107/rcub_farfar_4748 .