Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study
Аутори
Končar, I.Nikolić, D.
Milošević, Z.
Bogavac-Stanojević, Nataša
Ilić, N.
Dragaš, M.
Sladojević, M.
Marković, M.
Vujčić, A.
Filipović, N.
Davidović, L.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objectives: The study aimed to identify differences and compare anatomical and biomechanical features between elective and ruptured abdominal aortic aneurysms (AAAs). Methods: Data (clinical, anatomical, and biomechanical) of 98 patients with AAA, 75 (76.53%) asymptomatic (Group aAAA) and 23 (23.46%) ruptured AAA (Group rAAA), were prospectively collected and analyzed. Anatomical, morphological, and biomechanical imaging markers like peak wall stress (PWS) and rupture risk equivalent diameter (RRED), comorbid conditions, and demographics were compared between the groups. Biomechanical features were assessed by analysis of Digital Imaging and Communication in Medicine images by A4clinics (Vascops), and anatomical features were assessed by 3Surgery (Trimensio). Binary and multiple logistic regression analysis were used and adjusted for confounders. Accuracy was assessed using receiving operative characteristic (ROC) curve analysis. Results: In a multivariable model, including gender and ...age as confounder variables, maximal aneurysm diameter [MAD, odds ratio (OR) = 1.063], relative intraluminal thrombus (rILT, OR = 1.039), and total aneurysm volume (TAV, OR = 1.006) continued to be significant predictors of AAA rupture with PWS (OR = 1.010) and RRED (OR = 1.031). Area under the ROC curve values and correct classification (cc) for the same parameters and the model that combines MAD, TAV, and rILT were measured: MAD (0.790, cc = 75%), PWS (0.713, cc = 73%), RRED (0.717, cc = 55%), TAV (0.756, cc = 79%), rILT (0.656, cc = 60%), and MAD + TAV + rILT (0.797, cc = 82%). Conclusion: Based on our results, in addition to MAD, other important predictors of rupture that might be used during aneurysm surveillance are TAV and rILT. Biomechanical parameters (PWS, RRED) as valuable predictors should be assessed in prospective clinical trials. Similar studies on AAA smaller than 55 mm in diameter, even difficult to organize, would be of even greater clinical value. 2023 Koncar, Nikolic, Milosevic, Bogavac-Stanojevic, Ilic, Dragas, Sladojevic, Markovic, Vujcic, Filipovic and Davidovic.
Кључне речи:
AAA / ILT / PWS / risk prediction / RRED / volumeИзвор:
Frontiers in Surgery, 2023, 10Издавач:
- Frontiers Media S.A.
Финансирање / пројекти:
- Мултидисциплинарна истраживања релевантна за етиопатогенезу, дијагностику и савремени третман болести торакоабдоминалне аорте и њених грана (RS-MESTD-Basic Research (BR or ON)-175008)
DOI: 10.3389/fsurg.2023.1095224
ISSN: 2296-875X
PubMed: 37215356
WoS: 000989620700001
Scopus: 2-s2.0-85159883369
Институција/група
PharmacyTY - JOUR AU - Končar, I. AU - Nikolić, D. AU - Milošević, Z. AU - Bogavac-Stanojević, Nataša AU - Ilić, N. AU - Dragaš, M. AU - Sladojević, M. AU - Marković, M. AU - Vujčić, A. AU - Filipović, N. AU - Davidović, L. PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4772 AB - Objectives: The study aimed to identify differences and compare anatomical and biomechanical features between elective and ruptured abdominal aortic aneurysms (AAAs). Methods: Data (clinical, anatomical, and biomechanical) of 98 patients with AAA, 75 (76.53%) asymptomatic (Group aAAA) and 23 (23.46%) ruptured AAA (Group rAAA), were prospectively collected and analyzed. Anatomical, morphological, and biomechanical imaging markers like peak wall stress (PWS) and rupture risk equivalent diameter (RRED), comorbid conditions, and demographics were compared between the groups. Biomechanical features were assessed by analysis of Digital Imaging and Communication in Medicine images by A4clinics (Vascops), and anatomical features were assessed by 3Surgery (Trimensio). Binary and multiple logistic regression analysis were used and adjusted for confounders. Accuracy was assessed using receiving operative characteristic (ROC) curve analysis. Results: In a multivariable model, including gender and age as confounder variables, maximal aneurysm diameter [MAD, odds ratio (OR) = 1.063], relative intraluminal thrombus (rILT, OR = 1.039), and total aneurysm volume (TAV, OR = 1.006) continued to be significant predictors of AAA rupture with PWS (OR = 1.010) and RRED (OR = 1.031). Area under the ROC curve values and correct classification (cc) for the same parameters and the model that combines MAD, TAV, and rILT were measured: MAD (0.790, cc = 75%), PWS (0.713, cc = 73%), RRED (0.717, cc = 55%), TAV (0.756, cc = 79%), rILT (0.656, cc = 60%), and MAD + TAV + rILT (0.797, cc = 82%). Conclusion: Based on our results, in addition to MAD, other important predictors of rupture that might be used during aneurysm surveillance are TAV and rILT. Biomechanical parameters (PWS, RRED) as valuable predictors should be assessed in prospective clinical trials. Similar studies on AAA smaller than 55 mm in diameter, even difficult to organize, would be of even greater clinical value. 2023 Koncar, Nikolic, Milosevic, Bogavac-Stanojevic, Ilic, Dragas, Sladojevic, Markovic, Vujcic, Filipovic and Davidovic. PB - Frontiers Media S.A. T2 - Frontiers in Surgery T1 - Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study VL - 10 DO - 10.3389/fsurg.2023.1095224 ER -
@article{ author = "Končar, I. and Nikolić, D. and Milošević, Z. and Bogavac-Stanojević, Nataša and Ilić, N. and Dragaš, M. and Sladojević, M. and Marković, M. and Vujčić, A. and Filipović, N. and Davidović, L.", year = "2023", abstract = "Objectives: The study aimed to identify differences and compare anatomical and biomechanical features between elective and ruptured abdominal aortic aneurysms (AAAs). Methods: Data (clinical, anatomical, and biomechanical) of 98 patients with AAA, 75 (76.53%) asymptomatic (Group aAAA) and 23 (23.46%) ruptured AAA (Group rAAA), were prospectively collected and analyzed. Anatomical, morphological, and biomechanical imaging markers like peak wall stress (PWS) and rupture risk equivalent diameter (RRED), comorbid conditions, and demographics were compared between the groups. Biomechanical features were assessed by analysis of Digital Imaging and Communication in Medicine images by A4clinics (Vascops), and anatomical features were assessed by 3Surgery (Trimensio). Binary and multiple logistic regression analysis were used and adjusted for confounders. Accuracy was assessed using receiving operative characteristic (ROC) curve analysis. Results: In a multivariable model, including gender and age as confounder variables, maximal aneurysm diameter [MAD, odds ratio (OR) = 1.063], relative intraluminal thrombus (rILT, OR = 1.039), and total aneurysm volume (TAV, OR = 1.006) continued to be significant predictors of AAA rupture with PWS (OR = 1.010) and RRED (OR = 1.031). Area under the ROC curve values and correct classification (cc) for the same parameters and the model that combines MAD, TAV, and rILT were measured: MAD (0.790, cc = 75%), PWS (0.713, cc = 73%), RRED (0.717, cc = 55%), TAV (0.756, cc = 79%), rILT (0.656, cc = 60%), and MAD + TAV + rILT (0.797, cc = 82%). Conclusion: Based on our results, in addition to MAD, other important predictors of rupture that might be used during aneurysm surveillance are TAV and rILT. Biomechanical parameters (PWS, RRED) as valuable predictors should be assessed in prospective clinical trials. Similar studies on AAA smaller than 55 mm in diameter, even difficult to organize, would be of even greater clinical value. 2023 Koncar, Nikolic, Milosevic, Bogavac-Stanojevic, Ilic, Dragas, Sladojevic, Markovic, Vujcic, Filipovic and Davidovic.", publisher = "Frontiers Media S.A.", journal = "Frontiers in Surgery", title = "Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study", volume = "10", doi = "10.3389/fsurg.2023.1095224" }
Končar, I., Nikolić, D., Milošević, Z., Bogavac-Stanojević, N., Ilić, N., Dragaš, M., Sladojević, M., Marković, M., Vujčić, A., Filipović, N.,& Davidović, L.. (2023). Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study. in Frontiers in Surgery Frontiers Media S.A.., 10. https://doi.org/10.3389/fsurg.2023.1095224
Končar I, Nikolić D, Milošević Z, Bogavac-Stanojević N, Ilić N, Dragaš M, Sladojević M, Marković M, Vujčić A, Filipović N, Davidović L. Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study. in Frontiers in Surgery. 2023;10. doi:10.3389/fsurg.2023.1095224 .
Končar, I., Nikolić, D., Milošević, Z., Bogavac-Stanojević, Nataša, Ilić, N., Dragaš, M., Sladojević, M., Marković, M., Vujčić, A., Filipović, N., Davidović, L., "Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study" in Frontiers in Surgery, 10 (2023), https://doi.org/10.3389/fsurg.2023.1095224 . .