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Comparison of HPTLC and HPLC for determination of econazole nitrate in topical dosage forms

Authorized Users Only
2004
Authors
Popović, Gordana
Čakar, Mira
Vučićević, Katarina
Vladimirov, S
Agbaba, Danica
Article (Published version)
Metadata
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Abstract
HPTLC and HPLC methods have been established for separation and quantitative determination of econazole nitrate. HPTLC was performed on silica gel plates with n-butyl acetate-carbon tetrachloride-methanol-diethylamine, 3 + 6 + 2.5 + 0.5 (v/v), as mobile phase. Chromatographic zones, or spots, of econazole base and nitrate were used to quantify econazole nitrate. HPLC was performed on amino and C-8 columns with acetonitrile-water, 30 + 70 (v/v), pH 2.5 (adjusted with phosphoric acid), as a mobile phase. The chromatograms were characterized by single peaks of econazole (amino column) or nitrate (C-8 column). The methods were successfully used for determination of econazole nitrate in spray solution and vaginal pessaries.
Keywords:
econazole nitrate / HPTLC / HPLC / pharmaceutical formulations
Source:
Journal of Planar Chromatography - Modern TLC, 2004, 17, 2, 109-112
Publisher:
  • Research Inst Medicinal Plants, Budakalasz

DOI: 10.1556/JPC.17.2004.2.5

ISSN: 0933-4173

WoS: 000221981300005

Scopus: 2-s2.0-2942558545
[ Google Scholar ]
12
6
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/479
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Popović, Gordana
AU  - Čakar, Mira
AU  - Vučićević, Katarina
AU  - Vladimirov, S
AU  - Agbaba, Danica
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/479
AB  - HPTLC and HPLC methods have been established for separation and quantitative determination of econazole nitrate. HPTLC was performed on silica gel plates with n-butyl acetate-carbon tetrachloride-methanol-diethylamine, 3 + 6 + 2.5 + 0.5 (v/v), as mobile phase. Chromatographic zones, or spots, of econazole base and nitrate were used to quantify econazole nitrate. HPLC was performed on amino and C-8 columns with acetonitrile-water, 30 + 70 (v/v), pH 2.5 (adjusted with phosphoric acid), as a mobile phase. The chromatograms were characterized by single peaks of econazole (amino column) or nitrate (C-8 column). The methods were successfully used for determination of econazole nitrate in spray solution and vaginal pessaries.
PB  - Research Inst Medicinal Plants, Budakalasz
T2  - Journal of Planar Chromatography - Modern TLC
T1  - Comparison of HPTLC and HPLC for determination of econazole nitrate in topical dosage forms
VL  - 17
IS  - 2
SP  - 109
EP  - 112
DO  - 10.1556/JPC.17.2004.2.5
ER  - 
@article{
author = "Popović, Gordana and Čakar, Mira and Vučićević, Katarina and Vladimirov, S and Agbaba, Danica",
year = "2004",
abstract = "HPTLC and HPLC methods have been established for separation and quantitative determination of econazole nitrate. HPTLC was performed on silica gel plates with n-butyl acetate-carbon tetrachloride-methanol-diethylamine, 3 + 6 + 2.5 + 0.5 (v/v), as mobile phase. Chromatographic zones, or spots, of econazole base and nitrate were used to quantify econazole nitrate. HPLC was performed on amino and C-8 columns with acetonitrile-water, 30 + 70 (v/v), pH 2.5 (adjusted with phosphoric acid), as a mobile phase. The chromatograms were characterized by single peaks of econazole (amino column) or nitrate (C-8 column). The methods were successfully used for determination of econazole nitrate in spray solution and vaginal pessaries.",
publisher = "Research Inst Medicinal Plants, Budakalasz",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Comparison of HPTLC and HPLC for determination of econazole nitrate in topical dosage forms",
volume = "17",
number = "2",
pages = "109-112",
doi = "10.1556/JPC.17.2004.2.5"
}
Popović, G., Čakar, M., Vučićević, K., Vladimirov, S.,& Agbaba, D.. (2004). Comparison of HPTLC and HPLC for determination of econazole nitrate in topical dosage forms. in Journal of Planar Chromatography - Modern TLC
Research Inst Medicinal Plants, Budakalasz., 17(2), 109-112.
https://doi.org/10.1556/JPC.17.2004.2.5
Popović G, Čakar M, Vučićević K, Vladimirov S, Agbaba D. Comparison of HPTLC and HPLC for determination of econazole nitrate in topical dosage forms. in Journal of Planar Chromatography - Modern TLC. 2004;17(2):109-112.
doi:10.1556/JPC.17.2004.2.5 .
Popović, Gordana, Čakar, Mira, Vučićević, Katarina, Vladimirov, S, Agbaba, Danica, "Comparison of HPTLC and HPLC for determination of econazole nitrate in topical dosage forms" in Journal of Planar Chromatography - Modern TLC, 17, no. 2 (2004):109-112,
https://doi.org/10.1556/JPC.17.2004.2.5 . .

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