3,5-nonadiyne isolated from the rhizome of Cachrys ferulacea inhibits endogenous nitric oxide release by rat peritoneal macrophages
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3,5-Nonadiyne, in vitro, selectively inhibits endogenous nitric oxide release (IC50=6.7 +/- 0.8 mum) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation. 3,5-Nonadiyne was isolated from root essential oil of Cachrys ferulacea (L.) CALESTANI, synonym Prangos ferulacea (L.) LINDLEY, obtained by hydrodistillation and spectrometricaly identified unambiguously.
Keywords:3,5-nonadiyne / Cachrys ferulacea / Prangos ferulacea / endogenous nitric oxide / inhibition
Source:Chemical & Pharmaceutical Bulletin, 2004, 52, 7, 853-854
- Pharmaceutical Soc Japan, Tokyo