Surface treatment of indomethacin agglomerates with Eudragit
Authorized Users Only
2004
Authors
Bajdik, JPintye-Hodi, K
Planinsek, Odon
Tuske, Z
Tasić, Ljiljana

Regdon, G

Srcić, S
Eros, I
Article (Published version)

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Show full item recordAbstract
Indomethacin is a widely used anti-inflammatory drug with serious side-effects. This drug was used as a model drug for the coating of agglomerates with a permeable film (Eudragit NE). The agglomeration of the crystals increased the flowability of the bulk crystals. The coating further improved the flowability, and also the uniformity of the mass of the filled capsules. The coating film also influenced the wetting of the samples. The coating decreased the surface free energy and therefore reduced the adhesion forces between both the dry and the wet particles. The modification of the flow properties and the even capsule filling can be explained by this phenomenon. Since coating film does not dissolve in the artificial gastric juice, the dissolution test was performed only in the artificial intestinal juice. The dissolution of indomethacin from the coated sample was changed significantly. Accordingly, coating of the crystals can be performed in order to protect the mucosa of the gastroint...estinal tract or to promote the preparation of solid dosage form.
Keywords:
agglomerates / coating / Eudragit NE / indomethacin / surface free energySource:
Drug Development and Industrial Pharmacy, 2004, 30, 4, 381-388Publisher:
- Taylor & Francis Ltd, Abingdon
DOI: 10.1081/DDC-120030932
ISSN: 0363-9045
PubMed: 15132180
WoS: 000221123800006
Scopus: 2-s2.0-3342894089
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Institution/Community
PharmacyTY - JOUR AU - Bajdik, J AU - Pintye-Hodi, K AU - Planinsek, Odon AU - Tuske, Z AU - Tasić, Ljiljana AU - Regdon, G AU - Srcić, S AU - Eros, I PY - 2004 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/482 AB - Indomethacin is a widely used anti-inflammatory drug with serious side-effects. This drug was used as a model drug for the coating of agglomerates with a permeable film (Eudragit NE). The agglomeration of the crystals increased the flowability of the bulk crystals. The coating further improved the flowability, and also the uniformity of the mass of the filled capsules. The coating film also influenced the wetting of the samples. The coating decreased the surface free energy and therefore reduced the adhesion forces between both the dry and the wet particles. The modification of the flow properties and the even capsule filling can be explained by this phenomenon. Since coating film does not dissolve in the artificial gastric juice, the dissolution test was performed only in the artificial intestinal juice. The dissolution of indomethacin from the coated sample was changed significantly. Accordingly, coating of the crystals can be performed in order to protect the mucosa of the gastrointestinal tract or to promote the preparation of solid dosage form. PB - Taylor & Francis Ltd, Abingdon T2 - Drug Development and Industrial Pharmacy T1 - Surface treatment of indomethacin agglomerates with Eudragit VL - 30 IS - 4 SP - 381 EP - 388 DO - 10.1081/DDC-120030932 ER -
@article{ author = "Bajdik, J and Pintye-Hodi, K and Planinsek, Odon and Tuske, Z and Tasić, Ljiljana and Regdon, G and Srcić, S and Eros, I", year = "2004", abstract = "Indomethacin is a widely used anti-inflammatory drug with serious side-effects. This drug was used as a model drug for the coating of agglomerates with a permeable film (Eudragit NE). The agglomeration of the crystals increased the flowability of the bulk crystals. The coating further improved the flowability, and also the uniformity of the mass of the filled capsules. The coating film also influenced the wetting of the samples. The coating decreased the surface free energy and therefore reduced the adhesion forces between both the dry and the wet particles. The modification of the flow properties and the even capsule filling can be explained by this phenomenon. Since coating film does not dissolve in the artificial gastric juice, the dissolution test was performed only in the artificial intestinal juice. The dissolution of indomethacin from the coated sample was changed significantly. Accordingly, coating of the crystals can be performed in order to protect the mucosa of the gastrointestinal tract or to promote the preparation of solid dosage form.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Drug Development and Industrial Pharmacy", title = "Surface treatment of indomethacin agglomerates with Eudragit", volume = "30", number = "4", pages = "381-388", doi = "10.1081/DDC-120030932" }
Bajdik, J., Pintye-Hodi, K., Planinsek, O., Tuske, Z., Tasić, L., Regdon, G., Srcić, S.,& Eros, I.. (2004). Surface treatment of indomethacin agglomerates with Eudragit. in Drug Development and Industrial Pharmacy Taylor & Francis Ltd, Abingdon., 30(4), 381-388. https://doi.org/10.1081/DDC-120030932
Bajdik J, Pintye-Hodi K, Planinsek O, Tuske Z, Tasić L, Regdon G, Srcić S, Eros I. Surface treatment of indomethacin agglomerates with Eudragit. in Drug Development and Industrial Pharmacy. 2004;30(4):381-388. doi:10.1081/DDC-120030932 .
Bajdik, J, Pintye-Hodi, K, Planinsek, Odon, Tuske, Z, Tasić, Ljiljana, Regdon, G, Srcić, S, Eros, I, "Surface treatment of indomethacin agglomerates with Eudragit" in Drug Development and Industrial Pharmacy, 30, no. 4 (2004):381-388, https://doi.org/10.1081/DDC-120030932 . .