Indomethacin is a widely used anti-inflammatory drug with serious side-effects. This drug was used as a model drug for the coating of agglomerates with a permeable film (Eudragit NE). The agglomeration of the crystals increased the flowability of the bulk crystals. The coating further improved the flowability, and also the uniformity of the mass of the filled capsules. The coating film also influenced the wetting of the samples. The coating decreased the surface free energy and therefore reduced the adhesion forces between both the dry and the wet particles. The modification of the flow properties and the even capsule filling can be explained by this phenomenon. Since coating film does not dissolve in the artificial gastric juice, the dissolution test was performed only in the artificial intestinal juice. The dissolution of indomethacin from the coated sample was changed significantly. Accordingly, coating of the crystals can be performed in order to protect the mucosa of the gastroint...estinal tract or to promote the preparation of solid dosage form.
Keywords:
agglomerates / coating / Eudragit NE / indomethacin / surface free energy
Source:
Drug Development and Industrial Pharmacy, 2004, 30, 4, 381-388
TY - JOUR
AU - Bajdik, J
AU - Pintye-Hodi, K
AU - Planinsek, Odon
AU - Tuske, Z
AU - Tasić, Ljiljana
AU - Regdon, G
AU - Srcić, S
AU - Eros, I
PY - 2004
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/482
AB - Indomethacin is a widely used anti-inflammatory drug with serious side-effects. This drug was used as a model drug for the coating of agglomerates with a permeable film (Eudragit NE). The agglomeration of the crystals increased the flowability of the bulk crystals. The coating further improved the flowability, and also the uniformity of the mass of the filled capsules. The coating film also influenced the wetting of the samples. The coating decreased the surface free energy and therefore reduced the adhesion forces between both the dry and the wet particles. The modification of the flow properties and the even capsule filling can be explained by this phenomenon. Since coating film does not dissolve in the artificial gastric juice, the dissolution test was performed only in the artificial intestinal juice. The dissolution of indomethacin from the coated sample was changed significantly. Accordingly, coating of the crystals can be performed in order to protect the mucosa of the gastrointestinal tract or to promote the preparation of solid dosage form.
PB - Taylor & Francis Ltd, Abingdon
T2 - Drug Development and Industrial Pharmacy
T1 - Surface treatment of indomethacin agglomerates with Eudragit
VL - 30
IS - 4
SP - 381
EP - 388
DO - 10.1081/DDC-120030932
ER -
@article{
author = "Bajdik, J and Pintye-Hodi, K and Planinsek, Odon and Tuske, Z and Tasić, Ljiljana and Regdon, G and Srcić, S and Eros, I",
year = "2004",
abstract = "Indomethacin is a widely used anti-inflammatory drug with serious side-effects. This drug was used as a model drug for the coating of agglomerates with a permeable film (Eudragit NE). The agglomeration of the crystals increased the flowability of the bulk crystals. The coating further improved the flowability, and also the uniformity of the mass of the filled capsules. The coating film also influenced the wetting of the samples. The coating decreased the surface free energy and therefore reduced the adhesion forces between both the dry and the wet particles. The modification of the flow properties and the even capsule filling can be explained by this phenomenon. Since coating film does not dissolve in the artificial gastric juice, the dissolution test was performed only in the artificial intestinal juice. The dissolution of indomethacin from the coated sample was changed significantly. Accordingly, coating of the crystals can be performed in order to protect the mucosa of the gastrointestinal tract or to promote the preparation of solid dosage form.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "Surface treatment of indomethacin agglomerates with Eudragit",
volume = "30",
number = "4",
pages = "381-388",
doi = "10.1081/DDC-120030932"
}
Bajdik, J., Pintye-Hodi, K., Planinsek, O., Tuske, Z., Tasić, L., Regdon, G., Srcić, S.,& Eros, I.. (2004). Surface treatment of indomethacin agglomerates with Eudragit. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 30(4), 381-388.
https://doi.org/10.1081/DDC-120030932
Bajdik J, Pintye-Hodi K, Planinsek O, Tuske Z, Tasić L, Regdon G, Srcić S, Eros I. Surface treatment of indomethacin agglomerates with Eudragit. in Drug Development and Industrial Pharmacy. 2004;30(4):381-388.
doi:10.1081/DDC-120030932 .
Bajdik, J, Pintye-Hodi, K, Planinsek, Odon, Tuske, Z, Tasić, Ljiljana, Regdon, G, Srcić, S, Eros, I, "Surface treatment of indomethacin agglomerates with Eudragit" in Drug Development and Industrial Pharmacy, 30, no. 4 (2004):381-388,
https://doi.org/10.1081/DDC-120030932 . .
