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The anti-hyperalgesic effects of carbamazepine and oxcarbazepine are attenuated by treatment with adenosine receptor antagonists

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2004
Authors
Tomić, Maja
Vučković, Sonja M.
Stepanović-Petrović, Radica
Ugrešić, Nenad
Prostran, Milica
Bošković, B
Article (Published version)
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Abstract
The antinociceptive effects of carbamazepine and oxcarbazepine, and the influence of caffeine, were examined in a paw pressure test in rats. Carbamazepine (10-40 mg/kg; intraperitoneal, i.p.) and oxcarbazepine (40-160 mg/kg; i.p.) caused a significant dose-dependent reduction of the paw inflammatory hyperalgesia induced by concanavalin A (Con A), intraplantarly (i.pl.). A comparable pattern of antinociceptive effect of carbamazepine and oxcarbazepine was observed; the only difference is their potency, in that carbamazepine was about three times more potent than oxcarbazepine. Caffeine (5-20 mg/kg; i.p.), a non-selective adenosine receptor antagonist, significantly depressed the antinociceptive effects of carbamazepine and oxcarbazepine, in a dose- and time-dependent manner. Also, a significant depression of the antinociceptive effects of carbamazepine and oxcarbazepine was observed by pretreatment with 1,3-dipropyl-8-cyclopentylxantine (DPCPX, 0.4 and 0.8 mg/kg; i.p.), an adenosine A, ...receptor antagonist. These findings indicate that, in a paw inflammatory hyperalgesia in rats, the antinociceptive effects of both drugs are, at least partially, mediated by adenosine A(1) receptors. In conclusion, the present study suggests the potential clinical importance of carbamazepine and oxcarbazepine in the treatment of inflammatory pain. In addition, caffeine consumption could possibly depress the analgesic effects of both anticonvulsive drugs.

Keywords:
carbamazepine / oxcarbazepine / caffeine / rat / paw pressure test / inflammatory hyperalgesia
Source:
Pain, 2004, 111, 3, 253-260
Publisher:
  • Lippincott Williams & Wilkins, Philadelphia

DOI: 10.1016/j.pain.2004.07.010

ISSN: 0304-3959

PubMed: 15363868

WoS: 000224313700006

Scopus: 2-s2.0-4444357183
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/483
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Pharmacy

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