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dc.creatorTomić, Maja
dc.creatorVučković, Sonja M.
dc.creatorStepanović-Petrović, Radica
dc.creatorUgrešić, Nenad
dc.creatorProstran, Milica
dc.creatorBošković, B
dc.date.accessioned2019-09-02T10:58:14Z
dc.date.available2019-09-02T10:58:14Z
dc.date.issued2004
dc.identifier.issn0304-3959
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/483
dc.description.abstractThe antinociceptive effects of carbamazepine and oxcarbazepine, and the influence of caffeine, were examined in a paw pressure test in rats. Carbamazepine (10-40 mg/kg; intraperitoneal, i.p.) and oxcarbazepine (40-160 mg/kg; i.p.) caused a significant dose-dependent reduction of the paw inflammatory hyperalgesia induced by concanavalin A (Con A), intraplantarly (i.pl.). A comparable pattern of antinociceptive effect of carbamazepine and oxcarbazepine was observed; the only difference is their potency, in that carbamazepine was about three times more potent than oxcarbazepine. Caffeine (5-20 mg/kg; i.p.), a non-selective adenosine receptor antagonist, significantly depressed the antinociceptive effects of carbamazepine and oxcarbazepine, in a dose- and time-dependent manner. Also, a significant depression of the antinociceptive effects of carbamazepine and oxcarbazepine was observed by pretreatment with 1,3-dipropyl-8-cyclopentylxantine (DPCPX, 0.4 and 0.8 mg/kg; i.p.), an adenosine A, receptor antagonist. These findings indicate that, in a paw inflammatory hyperalgesia in rats, the antinociceptive effects of both drugs are, at least partially, mediated by adenosine A(1) receptors. In conclusion, the present study suggests the potential clinical importance of carbamazepine and oxcarbazepine in the treatment of inflammatory pain. In addition, caffeine consumption could possibly depress the analgesic effects of both anticonvulsive drugs.en
dc.publisherLippincott Williams & Wilkins, Philadelphia
dc.rightsrestrictedAccess
dc.sourcePain
dc.subjectcarbamazepineen
dc.subjectoxcarbazepineen
dc.subjectcaffeineen
dc.subjectraten
dc.subjectpaw pressure testen
dc.subjectinflammatory hyperalgesiaen
dc.titleThe anti-hyperalgesic effects of carbamazepine and oxcarbazepine are attenuated by treatment with adenosine receptor antagonistsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтепановић-Петровић, Радица; Вучковић, Соња М.; Томић, Маја; Угрешић, Ненад; Простран, Милица; Бошковић, Б;
dc.citation.volume111
dc.citation.issue3
dc.citation.spage253
dc.citation.epage260
dc.citation.other111(3): 253-260
dc.citation.rankaM21
dc.identifier.wos000224313700006
dc.identifier.doi10.1016/j.pain.2004.07.010
dc.identifier.pmid15363868
dc.identifier.scopus2-s2.0-4444357183
dc.identifier.rcubconv_1571
dc.type.versionpublishedVersion


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