In this paper the second-derivative spectrophotometric method for the simultaneous determination of lidocaine (CAS 137-58-6) and hydrocortisone acetate (CAS 50-03-3) in suppositories is described. One suppository contains 60 mg of lidocaine and 5 mg of hydrocortisone acetate. Optimal conditions for the quantitative analysis were settled. The second-derivative spectra were recorded in the range from 210 to 380 nm against methanol. Determination of lidocaine was performed at 256.0 nm and hydrocortisone acetate at 260.5 nm, using the "zero crossing" method. The results obtained show that there was no interference of ingredients matrix under the mentioned experimental conditions. The method is simple, rapid and precise and can be used in a routine analysis of such pharmaceutical dosage forms.
Keywords:
CAS 50-03-3 / CAS 137-58-6 / hydrocortisone acetate / lidocaine / second-derivative spectrophotometry / zero-crossing method
Source:
Pharmazeutische Industrie, 2004, 66, 3, 330-333
Publisher:
ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf
TY - JOUR
AU - Medenica, Mirjana
AU - Ivanović, D
AU - Marković, S
AU - Malenović, Anđelija
AU - Jančić, Biljana
PY - 2004
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/487
AB - In this paper the second-derivative spectrophotometric method for the simultaneous determination of lidocaine (CAS 137-58-6) and hydrocortisone acetate (CAS 50-03-3) in suppositories is described. One suppository contains 60 mg of lidocaine and 5 mg of hydrocortisone acetate. Optimal conditions for the quantitative analysis were settled. The second-derivative spectra were recorded in the range from 210 to 380 nm against methanol. Determination of lidocaine was performed at 256.0 nm and hydrocortisone acetate at 260.5 nm, using the "zero crossing" method. The results obtained show that there was no interference of ingredients matrix under the mentioned experimental conditions. The method is simple, rapid and precise and can be used in a routine analysis of such pharmaceutical dosage forms.
PB - ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf
T2 - Pharmazeutische Industrie
T1 - Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories
VL - 66
IS - 3
SP - 330
EP - 333
ER -
@article{
author = "Medenica, Mirjana and Ivanović, D and Marković, S and Malenović, Anđelija and Jančić, Biljana",
year = "2004",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/487",
abstract = "In this paper the second-derivative spectrophotometric method for the simultaneous determination of lidocaine (CAS 137-58-6) and hydrocortisone acetate (CAS 50-03-3) in suppositories is described. One suppository contains 60 mg of lidocaine and 5 mg of hydrocortisone acetate. Optimal conditions for the quantitative analysis were settled. The second-derivative spectra were recorded in the range from 210 to 380 nm against methanol. Determination of lidocaine was performed at 256.0 nm and hydrocortisone acetate at 260.5 nm, using the "zero crossing" method. The results obtained show that there was no interference of ingredients matrix under the mentioned experimental conditions. The method is simple, rapid and precise and can be used in a routine analysis of such pharmaceutical dosage forms.",
publisher = "ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf",
journal = "Pharmazeutische Industrie",
title = "Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories",
volume = "66",
number = "3",
pages = "330-333"
}
Medenica M, Ivanović D, Marković S, Malenović A, Jančić B. Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories. Pharmazeutische Industrie. 2004;66(3):330-333
Medenica, M., Ivanović, D., Marković, S., Malenović, A.,& Jančić, B. (2004). Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories.
Pharmazeutische IndustrieECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf., 66(3), 330-333.
Medenica Mirjana, Ivanović D, Marković S, Malenović Anđelija, Jančić Biljana, "Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories" 66, no. 3 (2004):330-333
