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dc.creatorMedenica, Mirjana
dc.creatorJančić, Biljana
dc.creatorIvanović, D
dc.creatorMalenović, Anđelija
dc.date.accessioned2019-09-02T10:58:21Z
dc.date.available2019-09-02T10:58:21Z
dc.date.issued2004
dc.identifier.issn0021-9673
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/489
dc.description.abstractFor the determination of the optimal RP-HPLC chromatographic conditions for the separation of imatinib mesylate and its impurity STI 509-00 experimental design 2(4) was applied. All the factors that affect imatinib mesylate/STI 509-00 separation, as well as their mutial interations were investigated. Methanol and triethylamine content in the mobile phase, pH of the mobile phase and column temperature were independent variables or factors to be investigated in two levels: "low" and "high". Capacity factor was chosen as a dependent variable. From the experimentally determined capacity factor values, it was defined the factors that affect to chromatographic system the most. Applying response surface methodology the appropriate graphs were constructed from experimental points and optimal chromatographic conditions for the separation were defined. Optimal conditions for the separation of imatinib mesylate and STI 509-00 were obtained using X Terra 150 mm x 4.6 mm, particle size 5 mum column at 25 degreesC. Mobile phase consisted of 250 ml of methanol, 740 ml of water and 10 ml of triehylamine. pH of water phase was adjusted to 2.4 with 85% orthophosphoric acid and than methanol was added.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Chromatography A
dc.subjectexperimental designen
dc.subjectpharmaceutical analysisen
dc.subjectimatinib mesylateen
dc.subjectSTI 509-00en
dc.titleExperimental design in reversed-phase high-performance liquid chromatographic analysis of imatinib mesylate and its impurityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаленовић, Aнђелија; Меденица, Мирјана; Јанчић, Биљана; Ивановић, Д;
dc.citation.volume1031
dc.citation.issue1-2
dc.citation.spage243
dc.citation.epage248
dc.citation.other1031(1-2): 243-248
dc.citation.rankaM21
dc.identifier.wos000220030800029
dc.identifier.doi10.1016/j.chroma.2003.12.029
dc.identifier.pmid15058589
dc.identifier.scopus2-s2.0-1342308130
dc.type.versionpublishedVersion


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