Linear solvation energy relationship study of selected imidazoline receptor ligands on α1-acid glycoprotein column
Апстракт
The retention properties of 22 selected imidazoline receptor ligands were studied by high-performance liquid chromatography on α1-acid glycoprotein (AGP) column using 2-propanol as organic additive and Sørensen phosphate buffer (pH 7.0). Linear solvation energy relationships (LSER) were built using isocratic retention factors - log k5, log k8, log k10, log k12, log k15 obtained for (5, 8, 10, 12, 15)% of 2- propanol in mobile phase, respectively and extrapolated log Kw values as dependant variables. Independent variables (Abraham descriptors) for LSER analysis were calculated by ACD/i-Lab software. LSER analysis indicated on McGowan volume, hydrogen bond basicity and excess molar refraction as the most important parameters for all isocratic retention factors and log Kw values of 22 selected imidazoline receptor ligands.
Извор:
PHYSICAL CHEMISTRY 2016 (Proceedings) 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 26-30, 2016, Belgrade, Serbia, 2016, II, 821-824Издавач:
- Society of Physical Chemists of Serbia
Финансирање / пројекти:
- Синтеза, квантитативни однос између структуре и дејства, физичко-хемијска карактеризација и анализа фармаколошки активних супстанци (RS-MESTD-Basic Research (BR or ON)-172033)
Напомена:
- 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 26-30, 2016, Belgrade, Serbia
Институција/група
PharmacyTY - CONF AU - Filipić, Slavica AU - Ružić, Dušan AU - Vučićević, Jelica AU - Nikolić, Katarina AU - Agbaba, Danica PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4914 AB - The retention properties of 22 selected imidazoline receptor ligands were studied by high-performance liquid chromatography on α1-acid glycoprotein (AGP) column using 2-propanol as organic additive and Sørensen phosphate buffer (pH 7.0). Linear solvation energy relationships (LSER) were built using isocratic retention factors - log k5, log k8, log k10, log k12, log k15 obtained for (5, 8, 10, 12, 15)% of 2- propanol in mobile phase, respectively and extrapolated log Kw values as dependant variables. Independent variables (Abraham descriptors) for LSER analysis were calculated by ACD/i-Lab software. LSER analysis indicated on McGowan volume, hydrogen bond basicity and excess molar refraction as the most important parameters for all isocratic retention factors and log Kw values of 22 selected imidazoline receptor ligands. PB - Society of Physical Chemists of Serbia C3 - PHYSICAL CHEMISTRY 2016 (Proceedings) 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 26-30, 2016, Belgrade, Serbia T1 - Linear solvation energy relationship study of selected imidazoline receptor ligands on α1-acid glycoprotein column VL - II SP - 821 EP - 824 UR - https://hdl.handle.net/21.15107/rcub_farfar_4914 ER -
@conference{ author = "Filipić, Slavica and Ružić, Dušan and Vučićević, Jelica and Nikolić, Katarina and Agbaba, Danica", year = "2016", abstract = "The retention properties of 22 selected imidazoline receptor ligands were studied by high-performance liquid chromatography on α1-acid glycoprotein (AGP) column using 2-propanol as organic additive and Sørensen phosphate buffer (pH 7.0). Linear solvation energy relationships (LSER) were built using isocratic retention factors - log k5, log k8, log k10, log k12, log k15 obtained for (5, 8, 10, 12, 15)% of 2- propanol in mobile phase, respectively and extrapolated log Kw values as dependant variables. Independent variables (Abraham descriptors) for LSER analysis were calculated by ACD/i-Lab software. LSER analysis indicated on McGowan volume, hydrogen bond basicity and excess molar refraction as the most important parameters for all isocratic retention factors and log Kw values of 22 selected imidazoline receptor ligands.", publisher = "Society of Physical Chemists of Serbia", journal = "PHYSICAL CHEMISTRY 2016 (Proceedings) 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 26-30, 2016, Belgrade, Serbia", title = "Linear solvation energy relationship study of selected imidazoline receptor ligands on α1-acid glycoprotein column", volume = "II", pages = "821-824", url = "https://hdl.handle.net/21.15107/rcub_farfar_4914" }
Filipić, S., Ružić, D., Vučićević, J., Nikolić, K.,& Agbaba, D.. (2016). Linear solvation energy relationship study of selected imidazoline receptor ligands on α1-acid glycoprotein column. in PHYSICAL CHEMISTRY 2016 (Proceedings) 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 26-30, 2016, Belgrade, Serbia Society of Physical Chemists of Serbia., II, 821-824. https://hdl.handle.net/21.15107/rcub_farfar_4914
Filipić S, Ružić D, Vučićević J, Nikolić K, Agbaba D. Linear solvation energy relationship study of selected imidazoline receptor ligands on α1-acid glycoprotein column. in PHYSICAL CHEMISTRY 2016 (Proceedings) 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 26-30, 2016, Belgrade, Serbia. 2016;II:821-824. https://hdl.handle.net/21.15107/rcub_farfar_4914 .
Filipić, Slavica, Ružić, Dušan, Vučićević, Jelica, Nikolić, Katarina, Agbaba, Danica, "Linear solvation energy relationship study of selected imidazoline receptor ligands on α1-acid glycoprotein column" in PHYSICAL CHEMISTRY 2016 (Proceedings) 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 26-30, 2016, Belgrade, Serbia, II (2016):821-824, https://hdl.handle.net/21.15107/rcub_farfar_4914 .