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Eliminacija paracetamola urinom kod pušača

dc.creatorKovačević, Ivan
dc.creatorMiljković, Branislava
dc.creatorBrzaković, Branka
dc.creatorMehmedagić, Aida
dc.creatorBrujić, Jelena
dc.creatorMilanović, Marija
dc.creatorPokrajac, Milena
dc.date.accessioned2019-09-02T10:58:32Z
dc.date.available2019-09-02T10:58:32Z
dc.date.issued2004
dc.identifier.issn0004-1963
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/497
dc.description.abstractThe aim of this study was to evaluate the influence of smoking on the urine paracetamol elimination. Fourteen healthy female volunteers took part in this controlled study. Seven (23+/-3 years; 50 +/- 2 kg; x+/-SD) were non-smokers and seven (26 +/- 9 years; 58 +/- 8 kg) were smokers (15 cigarettes per day). After administration of 500 mg of paracetamol, urine sampling was performed at specific times (before drug administration and 1, 2, 3, 4, 6, 9, 12, 16 and 24 hours after). The bioanalytical method used for determination of hydrolyzed paracetamol conjugates in urine samples was UV-spectrometry. The obtained pharmacokinetic parameters of paracetamol, first-order elimination rate constant (â) and elimination half-life (t1/2â), were statistically compared between non-smokers and smokers. There were no significant differences in both elimination parameters (â 0.311 1/h; t1/2â 2.23 h non-smokers vs. â 0.346 1/h; t1/2â 2.19 h smokers) between the groups. However, the differences obtained in inter-individual variability in pharmacokinetic parameters (â SD 0.013 , KV 13.4 % ; t1/2â SD 0.227, KV 4.57% nonsmokers vs. â SD 0.108 , KV 90 % ; t1/2â SD 0.684 , KV 14 % smokers) indicate relatively low predictability of paracetamol elimination in smokers. That requires higher attention in dosing this drug in smokers, especially if some other factors also influence.en
dc.description.abstractU radu je ispitivan uticaj sastojaka duvanskog dima na brzinu eliminacije paracetamola urinom. U kontrolisanom ispitivanju je učestvovalo 14 zdravih dobrovoljaca ženskog pola. Sedam su bili nepušači (23±8 godine; 50±2 kg: X±SD), a sedam (26±9 godina; 58±8 kg; X±SD) pušači (15 cigareta dnevno). Određivan je „ukupan” paracetamol u urinu UV- spektrometrijskom metodom, posle hidrolize konjugata paracetamola i oksidacije dobijenog proizvoda, u prisustvu hipobromita, do obojenog jedinjenja - derivata indofenola. Farmakokinetičkom analizom izmerenih koncentracija u urinu izračunati su farmakokinetički parametri: konstanta brzine eliminacije (â) i poluvreme eliminacije paracetamola (t1/2â). Mada vrednosti ovih parametara kod pušača ukazuju na bržu eliminaciju paracetamola, statističkim poređenjem farmakokinetičkih parametara eliminacije kod pušača (â=0,346 1/h i t1/2â=2,19 h) i nepušača (â=0,311 1/h, t1/2â=2,23 h), nije dobijena značajna razlika ( P lt 0,05). Veće vrednosti SD=0,108 i KV=90 % za â i SD=0,684 i KV= 14, 25 % za t1/2â u grupi pušača, u poređenju sa istim parametrima u grupi nepušača (SD=0,013 i KV=13,4 % za â i SD=0,227 i KV=4,57 % za t1/2â), pokazuju veću inter-individualnu varijabilnost farmakokinetičkih parametara eliminacije paracetamola kod pušača. Posledica je relativno niska predvidivost farmakokinetike paracetamola kod pušača, pa je kod njih potrebna veća pažnja u doziranju leka, naročito ako postoji i uticaj drugih faktora farmakokinetičke varijabilnosti.sr
dc.publisherSavez farmaceutskih udruženja Srbije, Beograd
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-sa/4.0/
dc.sourceArhiv za farmaciju
dc.subjectparacetamolen
dc.subjecteliminationen
dc.subjecturineen
dc.subjectpharmacokineticsen
dc.subjectsmokingen
dc.subjectparacetamolsr
dc.subjecteliminacijasr
dc.subjecturinsr
dc.subjectfarmakokinetikasr
dc.subjectpušenjesr
dc.titleThe influence of smoking on the urine paracetamol eliminationen
dc.titleEliminacija paracetamola urinom kod pušačasr
dc.typearticle
dc.rights.licenseBY-SA
dcterms.abstractПокрајац, Милена; Миљковић, Бранислава; Ковачевић, Иван; Мехмедагић, Aида; Брзаковић, Бранка; Милановић, Марија; Брујић, Јелена; Елиминација парацетамола урином код пушача; Елиминација парацетамола урином код пушача;
dc.citation.volume54
dc.citation.issue5
dc.citation.spage655
dc.citation.epage664
dc.citation.other54(5): 655-664
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/2018/495.pdf
dc.identifier.rcubconv_159
dc.type.versionpublishedVersion


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