Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation
Glavna komponentna analiza uticaja oksidativnog stresa, inflamacije i dislipidemije kod pacijenata sa različitim nivoom glikoregulacije
dc.creator | Malenica, Maja | |
dc.creator | Klisić, Aleksandra | |
dc.creator | Meseldžić, Neven | |
dc.creator | Dujić, Tanja | |
dc.creator | Bego, Tamer | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.date.accessioned | 2023-08-30T11:37:47Z | |
dc.date.available | 2023-08-30T11:37:47Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1452-8258 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/4992 | |
dc.description.abstract | Background: The aim of the study was to explore the mutual relationship between oxidative stress, inflammation and metabolic biomarkers in subjects with prediabetes (PRE), newly diagnosed type 2 diabetes patients (NT2D) and overt type 2 diabetes (T2D) using principal component analysis (PCA) as a thorough statistical approach. Methods: Glycated hemoglobin, lipid parameters, inflammation (IL-6, CRP and fibrinogen) and oxidative stress markers pro-oxidants (AOPP, PAB, TOS) and antioxidants (PON1, tSHG, TAS) were measured. PCA was applied to explore the factors that the most strongly influenced glucoregulation. Results: A total of 278 subjects were (i.e., 37 PRE, 42 NT2D and 99 T2D) were compared with 100 healthy subjects as a control group (CG). PCA emphasized 4 different factors explaining 49% of the variance of the tested parameters: oxidative stress-dyslipidemia related factor (with positive loading of TG and tSHG, and with negative loading of HDL-c and TAS), dyslipidaemia related factor (i.e., total cholesterol and LDL-c, both with positive loading), Anthropometric related factor (i.e., waist and hip circumference, both with positive loading) and oxidative stress- Inflammation related factor (i.e., PAB, fibrinogen, and CRP, all with positive loading). Out of these 4 factors, only oxidative stress – dyslipidaemia related factor showed a significant predictive capability towards poor glucoregulation. An increase in this factor by one unit showed a 1.6 times higher probability for poor glucoregulation. Conclusions: Redox imbalance (determined with lower TAS and higher tSHG), in addition to higher TG and lower HDL- c was associated with poor glucoregulation. | sr |
dc.description.abstract | Uvod: Cilj istraživanja je bio da se ispita povezanost oksidativnog stresa, inflamacije i metaboličkih biomarkera kod pacijenata sa predijabetesom (PRE), de novo dijabetesom (NT2D) i ranije dijagnostikovanim dijabetesom (T2D) pomoću glavne komponentne analize (PCA). Metode: Glikozilirani hemoglobin, lipidni status, markeri inflamacije (IL-6, CRP i fibrinogen), parametri oksidativnog stresa pro-oksidanti (AOPP, PAB, TOS) i antioksidansi (PON1, tSHG, TAS) su mereni. PCA je primenjena da bi se ispitali faktori koji najviše utiču na glikoregulaciju. Rezultati: U istraživanje je uključeno 278 ispitanika: 37 PRE, 42 NT2D i 99 T2D, kao i 100 zdravih osoba koji su činili kontrolnu grupu (CG). PCA je izdvojila 4 različita faktora objašnjavajući 49% varijanse ispitivanih parametara: oksidativni stres-dislipidemija faktor (sa pozitivnim uticajem TG i tSHG, i negativnim uticajem HDL-c i TAS), dislipidemija faktor (tj, ukupni holesterol i LDL-c, oba sa pozitivnim uticajem), antropometrijski faktor (tj, obim struka i kukova, oba sa pozitivnim uticajem) i oksidativni stres-inflamacija faktor (tj, PAB, fibrinogen i CRP, svi sa pozitivnim uticajem). Od ova 4 faktora, jedino je oksidativni stres - dislipidemija faktor pokazao značajnu prediktivnu sposobnost za lošu glikoregulaciju. Porast ovog faktora za jednu jedinicu je pokazao 1,6 puta veću verovatnoću za lošu glikoregulaciju. Zaključak: Redoks disbalans (određen nižim vrednostima TAS i višim vrednostima tSHG), kao dodatak većim vrednostima TG i nižim vrednostima HDL-c su povezane sa lošijom glikoregulacijom. | sr |
dc.language.iso | sr | sr |
dc.language.iso | en | sr |
dc.publisher | Society of Medical Biochemists of Serbia | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Journal of Medical Biochemistry | sr |
dc.subject | antioxidants | sr |
dc.subject | prooxidants | sr |
dc.subject | glycemic control | sr |
dc.subject | inflammation | sr |
dc.subject | dyslipidemia | sr |
dc.subject | antioksidansi | sr |
dc.subject | pro-oksidansi | sr |
dc.subject | kontrola glikemije | sr |
dc.subject | inflamacija | sr |
dc.subject | dislipidemija | sr |
dc.title | Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation | sr |
dc.title | Glavna komponentna analiza uticaja oksidativnog stresa, inflamacije i dislipidemije kod pacijenata sa različitim nivoom glikoregulacije | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.citation.volume | 42 | |
dc.citation.issue | 3 | |
dc.citation.spage | 427 | |
dc.citation.epage | 436 | |
dc.citation.rank | M23~ | |
dc.identifier.wos | 001044436200011 | |
dc.identifier.doi | 10.5937/jomb0-39636 | |
dc.identifier.pmid | 37814622 | |
dc.identifier.scopus | 2-s2.0-85173159772 | |
dc.identifier.fulltext | http://farfar.pharmacy.bg.ac.rs/bitstream/id/13730/Principal_component_analysis_pub_2023.pdf | |
dc.type.version | publishedVersion | sr |