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dc.creatorParojčić, Jelena
dc.creatorĐurić, Zorica
dc.creatorJovanović, M
dc.creatorIbrić, Svetlana
dc.date.accessioned2019-09-02T10:58:37Z
dc.date.available2019-09-02T10:58:37Z
dc.date.issued2004
dc.identifier.issn1071-7544
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/499
dc.description.abstractDrug release from hydrophilic matrix tablets can be strongly influenced by the proportion of matrix forming polymer and the dimensions and geometry of the tablets. A complete two-factor, three-level factorial design, followed by multiple regression analysis and response surface methodology, was applied to investigate the influence of polymer level and tablet size on drug release kinetics from hydrophilic matrix tablets prepared with Carbopol 971P and Carbopol 71G. Tablet diameter, radius-to-height ratio, tablet surface area, and surface-area-to-volume ratio were evaluated as independent variables in terms of their applicability to characterize tablet size and geometry. The results indicate that it may be possible to control the rate of drug release by modifying the proportion of carbomer in tablets and tablet dimensions. The practical benefit of these simulations is to optimize the geometry and dimensions of a controlled release device and reduce the number of experiments involved in the development of new controlled release dosage forms.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceDrug Delivery
dc.subjectcarbomeren
dc.subjectdissolutionen
dc.subjectdrug deliveryen
dc.subjecthydrophilic matrix tableten
dc.subjectparacetamolen
dc.subjectsustained releaseen
dc.titleAn investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymersen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractИбрић, Светлана; Јовановић, М; Ђурић, Зорица; Паројчић, Јелена;
dc.citation.volume11
dc.citation.issue1
dc.citation.spage59
dc.citation.epage65
dc.citation.other11(1): 59-65
dc.citation.rankM23
dc.identifier.wos000220043600009
dc.identifier.doi10.1080/10717540490265379
dc.identifier.pmid15168793
dc.identifier.scopus2-s2.0-19244378905
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/2019/497.pdf
dc.type.versionpublishedVersion


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