The effects of anoinic and cationic surfactants on acid-base equilibria of irbesartan
Апстракт
In this study the pKa values of irbesartan, an angiotensin receptor blocker, were
determined by potentiometry and the effects of sodium dodecyl sulfate
(SDS) and cetyl trimethyl ammonium bromide (CTAB) on its protolytic
equilibria have been investigated. It was observed that shift in pKa values is
a result of complex electrostatic and hydrophobic interactions with the
micelar solutions. Based on the obtained results drug interactions with
biomolecules can be evaluated.
Кључне речи:
sartans / protolytic equilibria / micellesИзвор:
PHYSICAL CHEMISTRY 2014, 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 22-26, 2014 Belgrade, Serbia, 2014, I, 1133-1136Издавач:
- Society of Physical Chemists of Serbia
Финансирање / пројекти:
- Синтеза, квантитативни однос између структуре и дејства, физичко-хемијска карактеризација и анализа фармаколошки активних супстанци (RS-MESTD-Basic Research (BR or ON)-172033)
Напомена:
- 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 22-26, 2014 Belgrade, Serbia
Институција/група
PharmacyTY - CONF AU - Popović, Marija AU - Grujić, Maja AU - Popović, Gordana AU - Agbaba, Danica PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5017 AB - In this study the pKa values of irbesartan, an angiotensin receptor blocker, were determined by potentiometry and the effects of sodium dodecyl sulfate (SDS) and cetyl trimethyl ammonium bromide (CTAB) on its protolytic equilibria have been investigated. It was observed that shift in pKa values is a result of complex electrostatic and hydrophobic interactions with the micelar solutions. Based on the obtained results drug interactions with biomolecules can be evaluated. PB - Society of Physical Chemists of Serbia C3 - PHYSICAL CHEMISTRY 2014, 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 22-26, 2014 Belgrade, Serbia T1 - The effects of anoinic and cationic surfactants on acid-base equilibria of irbesartan VL - I SP - 1133 EP - 1136 UR - https://hdl.handle.net/21.15107/rcub_farfar_5017 ER -
@conference{ author = "Popović, Marija and Grujić, Maja and Popović, Gordana and Agbaba, Danica", year = "2014", abstract = "In this study the pKa values of irbesartan, an angiotensin receptor blocker, were determined by potentiometry and the effects of sodium dodecyl sulfate (SDS) and cetyl trimethyl ammonium bromide (CTAB) on its protolytic equilibria have been investigated. It was observed that shift in pKa values is a result of complex electrostatic and hydrophobic interactions with the micelar solutions. Based on the obtained results drug interactions with biomolecules can be evaluated.", publisher = "Society of Physical Chemists of Serbia", journal = "PHYSICAL CHEMISTRY 2014, 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 22-26, 2014 Belgrade, Serbia", title = "The effects of anoinic and cationic surfactants on acid-base equilibria of irbesartan", volume = "I", pages = "1133-1136", url = "https://hdl.handle.net/21.15107/rcub_farfar_5017" }
Popović, M., Grujić, M., Popović, G.,& Agbaba, D.. (2014). The effects of anoinic and cationic surfactants on acid-base equilibria of irbesartan. in PHYSICAL CHEMISTRY 2014, 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 22-26, 2014 Belgrade, Serbia Society of Physical Chemists of Serbia., I, 1133-1136. https://hdl.handle.net/21.15107/rcub_farfar_5017
Popović M, Grujić M, Popović G, Agbaba D. The effects of anoinic and cationic surfactants on acid-base equilibria of irbesartan. in PHYSICAL CHEMISTRY 2014, 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 22-26, 2014 Belgrade, Serbia. 2014;I:1133-1136. https://hdl.handle.net/21.15107/rcub_farfar_5017 .
Popović, Marija, Grujić, Maja, Popović, Gordana, Agbaba, Danica, "The effects of anoinic and cationic surfactants on acid-base equilibria of irbesartan" in PHYSICAL CHEMISTRY 2014, 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 22-26, 2014 Belgrade, Serbia, I (2014):1133-1136, https://hdl.handle.net/21.15107/rcub_farfar_5017 .