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Diuretic activity of Maydis stigma extract in rats

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Authors
Maksimović, Zoran
Dobrić, Silva
Kovačević, Nada
Milovanović, Z
Article (Published version)
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Abstract
Maydis stigma (corn silk) is a herbal drug reputed for the treatment of urinary ailments in various traditional medicine systems. To determine its influence on urinary volume and the excretion of sodium, potassium and chloride, 5% and 10% decoctions were administered daily to adult male Wistar rats for eight days. The concentration of electrolytes and urea in plasma, the influence of treatment on urinary pH value as well as creatinine clearance were also investigated. Daily oral administration of 5% decoction at the dose of 10 ml/kg led to a significant and acute diuresis in rats, reaching the peak value in the first 24 h of treatment. Over a similar period, application of 10% decoction did not affect urinary excretion of water, but significantly increased the pH value of excreted urine. A significant decrease in sodium and chloride plasma levels was observed in both treated groups. The creatinine clearance was markedly increased after the treatment with both extracts. Our findings ind...icate that the diuretic effect of 5% aqueous Maydis stigma extract is in accordance with the increase in glomerular filtration rate and inhibition of sodium and chloride tubular reabsorption, caused a by still unidentified intrinsic factor, but not the salt-loading effect.

Source:
Pharmazie, 2004, 59, 12, 967-971
Publisher:
  • Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn

ISSN: 0031-7144

PubMed: 15638089

WoS: 000225704600015

Scopus: 2-s2.0-10844296674
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/502
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Pharmacy

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