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dc.creatorMaksimović, Zoran
dc.creatorDobrić, Silva
dc.creatorKovačević, Nada
dc.creatorMilovanović, Z
dc.date.accessioned2019-09-02T10:58:40Z
dc.date.available2019-09-02T10:58:40Z
dc.date.issued2004
dc.identifier.issn0031-7144
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/502
dc.description.abstractMaydis stigma (corn silk) is a herbal drug reputed for the treatment of urinary ailments in various traditional medicine systems. To determine its influence on urinary volume and the excretion of sodium, potassium and chloride, 5% and 10% decoctions were administered daily to adult male Wistar rats for eight days. The concentration of electrolytes and urea in plasma, the influence of treatment on urinary pH value as well as creatinine clearance were also investigated. Daily oral administration of 5% decoction at the dose of 10 ml/kg led to a significant and acute diuresis in rats, reaching the peak value in the first 24 h of treatment. Over a similar period, application of 10% decoction did not affect urinary excretion of water, but significantly increased the pH value of excreted urine. A significant decrease in sodium and chloride plasma levels was observed in both treated groups. The creatinine clearance was markedly increased after the treatment with both extracts. Our findings indicate that the diuretic effect of 5% aqueous Maydis stigma extract is in accordance with the increase in glomerular filtration rate and inhibition of sodium and chloride tubular reabsorption, caused a by still unidentified intrinsic factor, but not the salt-loading effect.en
dc.publisherGovi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn
dc.rightsrestrictedAccess
dc.sourcePharmazie
dc.titleDiuretic activity of Maydis stigma extract in ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКовачевић, Нада; Добрић, Силва; Максимовић, Зоран; Миловановић, З;
dc.citation.volume59
dc.citation.issue12
dc.citation.spage967
dc.citation.epage971
dc.citation.other59(12): 967-971
dc.citation.rankM23
dc.identifier.wos000225704600015
dc.identifier.pmid15638089
dc.identifier.scopus2-s2.0-10844296674
dc.identifier.rcubconv_1581
dc.type.versionpublishedVersion


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