Study of acid hydrolysis of bromazepam
Само за регистроване кориснике
2004
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Quantitative study of an acid hydrolysis of bromazepam, which in acidic solution simultaneously undergoes reversible 4,5-azomethine bond cleavage and protolytic reactions, was performed (t = 25degreesC). When an equilibrium is established, four species are simultaneously present in solution. Two approaches, both based on theoretically derived dependence between the absorbance (A) and the solution acidity ([H3O+]), were used to determine appropriate equilibrium constants. In the first, the least-squares method was used to fit experimentally obtained (A, [H3O+]) value pairs to a derived function. With values obtained as fitting parameters, the probability distribution for equilibrium constants was calculated with the virtual experiments performed using Monte Carlo simulations. In the second one, spectrophotometric analysis indicated an existence of two distinct pH intervals, both with three dominant species involved. Spectral data were used to calculate equilibrium constants by a linear ...curve fitting analysis. Values obtained for equilibrium constants from the numerical and the experimental approaches are in good accordance and were used to calculate distribution of all the species as a function of pc(H).
Кључне речи:
bromazepam / acid hydrolysis / equilibrium constantsИзвор:
Canadian Journal of Chemistry, 2004, 82, 8, 1260-1265Издавач:
- Canadian Science Publishing, Nrc Research Press, Ottawa
DOI: 10.1139/V04-091
ISSN: 0008-4042
WoS: 000224976200005
Scopus: 2-s2.0-11244304867
Институција/група
PharmacyTY - JOUR AU - Damjanović, Tatjana AU - Popović, Gordana AU - Verbić, Srđan AU - Pfendt, Lidija PY - 2004 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/504 AB - Quantitative study of an acid hydrolysis of bromazepam, which in acidic solution simultaneously undergoes reversible 4,5-azomethine bond cleavage and protolytic reactions, was performed (t = 25degreesC). When an equilibrium is established, four species are simultaneously present in solution. Two approaches, both based on theoretically derived dependence between the absorbance (A) and the solution acidity ([H3O+]), were used to determine appropriate equilibrium constants. In the first, the least-squares method was used to fit experimentally obtained (A, [H3O+]) value pairs to a derived function. With values obtained as fitting parameters, the probability distribution for equilibrium constants was calculated with the virtual experiments performed using Monte Carlo simulations. In the second one, spectrophotometric analysis indicated an existence of two distinct pH intervals, both with three dominant species involved. Spectral data were used to calculate equilibrium constants by a linear curve fitting analysis. Values obtained for equilibrium constants from the numerical and the experimental approaches are in good accordance and were used to calculate distribution of all the species as a function of pc(H). PB - Canadian Science Publishing, Nrc Research Press, Ottawa T2 - Canadian Journal of Chemistry T1 - Study of acid hydrolysis of bromazepam VL - 82 IS - 8 SP - 1260 EP - 1265 DO - 10.1139/V04-091 ER -
@article{ author = "Damjanović, Tatjana and Popović, Gordana and Verbić, Srđan and Pfendt, Lidija", year = "2004", abstract = "Quantitative study of an acid hydrolysis of bromazepam, which in acidic solution simultaneously undergoes reversible 4,5-azomethine bond cleavage and protolytic reactions, was performed (t = 25degreesC). When an equilibrium is established, four species are simultaneously present in solution. Two approaches, both based on theoretically derived dependence between the absorbance (A) and the solution acidity ([H3O+]), were used to determine appropriate equilibrium constants. In the first, the least-squares method was used to fit experimentally obtained (A, [H3O+]) value pairs to a derived function. With values obtained as fitting parameters, the probability distribution for equilibrium constants was calculated with the virtual experiments performed using Monte Carlo simulations. In the second one, spectrophotometric analysis indicated an existence of two distinct pH intervals, both with three dominant species involved. Spectral data were used to calculate equilibrium constants by a linear curve fitting analysis. Values obtained for equilibrium constants from the numerical and the experimental approaches are in good accordance and were used to calculate distribution of all the species as a function of pc(H).", publisher = "Canadian Science Publishing, Nrc Research Press, Ottawa", journal = "Canadian Journal of Chemistry", title = "Study of acid hydrolysis of bromazepam", volume = "82", number = "8", pages = "1260-1265", doi = "10.1139/V04-091" }
Damjanović, T., Popović, G., Verbić, S.,& Pfendt, L.. (2004). Study of acid hydrolysis of bromazepam. in Canadian Journal of Chemistry Canadian Science Publishing, Nrc Research Press, Ottawa., 82(8), 1260-1265. https://doi.org/10.1139/V04-091
Damjanović T, Popović G, Verbić S, Pfendt L. Study of acid hydrolysis of bromazepam. in Canadian Journal of Chemistry. 2004;82(8):1260-1265. doi:10.1139/V04-091 .
Damjanović, Tatjana, Popović, Gordana, Verbić, Srđan, Pfendt, Lidija, "Study of acid hydrolysis of bromazepam" in Canadian Journal of Chemistry, 82, no. 8 (2004):1260-1265, https://doi.org/10.1139/V04-091 . .