Приказ основних података о документу

dc.creatorŽivanović, L
dc.creatorIvanović, I
dc.creatorSolomun, Ljiljana
dc.creatorZečević, Mira
dc.date.accessioned2019-09-02T10:58:53Z
dc.date.available2019-09-02T10:58:53Z
dc.date.issued2004
dc.identifier.issn0009-5893
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/510
dc.description.abstractCefuroxime is a broad-spectrum second-generation bactericidal cephalosporin antibiotic active against beta-lactamose-producing strains. Anti-cefuroxime, the geometric isomer of cefuroxime, might be present in cefuroxime dosage forms as a process-related impurity and possible degradation product. In the work discussed in this paper a precise and sensitive micellar liquid chromatographic (MLC) method for stability testing of cefuroxime axetil and anti-cefuroxime axetil in tablets, using benzoic acid as internal standard, was developed and validated. MLC was performed on an XTerra C-18 reversed-phase column at 50 degreesC with 8:92 (v/v) acetonitrile-20 mm sodium dodecyl sulphate, pH 2.5, as mobile phase at a flow rate of 1.5 mL min(-1). Detection was at 280 nm. Under these conditions the retention time and retention factor were of 6.65 min and 4.57, respectively, for cefuroxime axetil and 11.45 min and 8.59, respectively, for anti-cefuroxime axetil, indicating that the compounds were well separated. RSD values for quantification of cefuroxime axetil and anti-cefuroxime axetil were 0.39 and 1.7%, respectively, indicating the precision of the MLC method was good. The method is sensitive-LOD = 0.5 mug mL(-1) and LOQ = 1.5 mug mL(-1) for anti-cefuroxime axetil-and reproducible, with good recovery values.en
dc.publisherSpringer Heidelberg, Heidelberg
dc.rightsrestrictedAccess
dc.sourceChromatographia
dc.subjectmicellar liquid chromatographyen
dc.subjectstability testingen
dc.subjectcefuroxime axetilen
dc.subjectanti-cefuroxime axetilen
dc.titleStability testing of cefuroxime in tablets by micellar liquid chromatographyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЖивановић, Л; Ивановић, И; Соломун, Љиљана; Зечевић, Мира;
dc.citation.volume60
dc.citation.issueSUPPL.
dc.citation.other60: -
dc.citation.rankM22
dc.identifier.wos000224155700009
dc.identifier.doi10.1365/s10337-004-0237-5
dc.identifier.scopus2-s2.0-3943102031
dc.type.versionpublishedVersion


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Приказ основних података о документу