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Protolitičke ravnoteže u homogenim i heterogenim vodenim sistemima metil- i propilparabena i uticaj β -ciklodekstrina na pKa vrednosti

dc.creatorPopović, Gordana
dc.creatorČakar, Mira
dc.date.accessioned2019-09-02T10:58:55Z
dc.date.available2019-09-02T10:58:55Z
dc.date.issued2004
dc.identifier.issn0004-1963
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/512
dc.description.abstractAcidity constants (Ka) and intrinsic hydrosolubility (Ks0) of two parabens, methylparaben and propylparaben, were spectrophotometrically determined at 25oC and a constant ionic strength of I=0.1 M (NaCl). Based on the determined equilibrium constants Ks0 and Ka, equilibrium constant Ks1 in heterogeneous system of methyl-and propylparaben was calculated. Solubility of the two parabens as a function of solution acidity was calculated applying the equation: s1 s0 3 [ ] S [H O ] K K + = + In addition, the effects of varying β-cyclodextrin concentrations on pKa values of the two parabens were examined. The results showed that β-CD influenced absorption spectra of the parabens (a decreased absorptivity and a bathochromic shift of the absorption maxima), but their pKa values remained almost unchanged.en
dc.description.abstractSpektrofotometrijski su određene kiselinske konstante (Ka) i osnovna rastvorljivost (Ks0) u vodi metilparabena i propilparabena. Određivanja su vršena na temperaturi od 25 oC i pri konstantnoj jonskoj sili I=0.1 M (NaCl). Na osnovu određenih ravnotežnih konstanti Ks0 i Ka izračunata je ravnotežna konstanta Ks1 u heterogenom sistemu parabena. Rastvorljivost parabena u funkciji kiselosti rastvora izračunata je primenom jednačine 1 0 3 [ ] [ ] s s K S K H O+ = + Pored toga, ispitan je uticaj različitih koncentracija β-ciklodekstrina na pKa vrednosti datih parabena.sr
dc.publisherSavez farmaceutskih udruženja Srbije, Beograd
dc.rightsopenAccess
dc.sourceArhiv za farmaciju
dc.subjectmethylparabenen
dc.subjectpropylparabenen
dc.subjectsolubilityen
dc.subjectacidity constanten
dc.subjectmetilparabensr
dc.subjectpropilparabensr
dc.subjectrastvorljivostsr
dc.subjectkiselinska konstantasr
dc.titleProtolytic equilibria in homogeneous and heterogeneous aqueous systems of methyl- and propylparaben and influence of β-cyclodextrin on pKa valuesen
dc.titleProtolitičke ravnoteže u homogenim i heterogenim vodenim sistemima metil- i propilparabena i uticaj β -ciklodekstrina na pKa vrednostisr
dc.typearticle
dc.rights.licenseBY-SA
dcterms.abstractЧакар, Мира; Поповић, Гордана; Протолитичке равнотеже у хомогеним и хетерогеним воденим системима метил- и пропилпарабена и утицај β -циклодекстрина на пКа вредности; Протолитичке равнотеже у хомогеним и хетерогеним воденим системима метил- и пропилпарабена и утицај β -циклодекстрина на пКа вредности;
dc.citation.volume54
dc.citation.issue5
dc.citation.spage601
dc.citation.epage611
dc.citation.other54(5): 601-611
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/2033/510.pdf
dc.identifier.rcubconv_156
dc.type.versionpublishedVersion


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