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dc.creatorRadenković, D
dc.creatorBajec, D
dc.creatorKaramarković, A
dc.creatorStefanović, B
dc.creatorMilić, N
dc.creatorIgnjatović, Svetlana
dc.creatorGregorić, P
dc.creatorMilicević, M
dc.date.accessioned2019-09-02T10:59:00Z
dc.date.available2019-09-02T10:59:00Z
dc.date.issued2004
dc.identifier.issn0885-3177
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/513
dc.description.abstractObjectives: Several clinical studies of severe necrotizing pancreatitis ( SNP) suggest profound activation of coagulation as well as activation of the fibrinolytic system. The aim of this study was to evaluate the hemostatic derangements in patients who were managed for SNP. Methods: Forty-one operated-on patients with SNP were analyzed regarding clinical outcome and activation of the coagulation systems. Serial measurement of coagulation, anticoagulation, and fibrinolysis parameters: prothrombin time ( PT), activated partial thromboplastin time (APTT), fibrinogen, antithrombin III ( AT III), protein C, plasminogen activator inhibitor-1 (PAI-1), D-dimer, alpha(2)-antiplasmin, and plasminogen were performed on days 1, 3, 5, 7, 10, and 14 after the initial operation. According to treatment outcome at the end of study, groups of 26 survivors and 15 nonsurvivors were compared. Results: Nonsurvivors had significantly lower levels of activity of protein C and AT III, and higher concentrations of D-dimer and PAI-1 than survivors. The other measured parameters did not show significant differences between the compared groups of patients. Conclusions: Changes in protein C, AT III, D-dimer and PAI-1 levels indicate exhaustion of fibrinolysis and coagulation inhibitors in patients with poor outcome during the course of SNP.en
dc.publisherLippincott Williams & Wilkins, Philadelphia
dc.rightsrestrictedAccess
dc.sourcePancreas
dc.subjectacute pancreatitisen
dc.subjectdisorders of hemostasisen
dc.subjectprotein C-antithrombin IIIen
dc.subjectD-dimeren
dc.subjectplasminogen activator inhibitor-1en
dc.titleDisorders of hemostasis during the surgical management of severe necrotizing pancreatitisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтефановић, Б; Грегорић, П; Раденковић, Д; Милић, Н; Игњатовић, Светлана; Милицевић, М; Бајец, Д; Карамарковић, A;
dc.citation.volume29
dc.citation.issue2
dc.citation.spage152
dc.citation.epage156
dc.citation.other29(2): 152-156
dc.citation.rankM22
dc.identifier.wos000224458000010
dc.identifier.doi10.1097/00006676-200408000-00010
dc.identifier.pmid15257107
dc.identifier.scopus2-s2.0-3242744594
dc.type.versionpublishedVersion


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