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Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid

Authorized Users Only
2004
Authors
Jovanović, MS
Popović, Gordana
Kapetanović, Vera
Orlić, M
Vladimirov, S
Article (Published version)
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Abstract
In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively.
Keywords:
iminodiacetic acid / METHYLIODIDA / ionization constants / potentiometry
Source:
Journal of Pharmaceutical and Biomedical Analysis, 2004, 35, 5, 1257-1261
Publisher:
  • Elsevier Science BV, Amsterdam

DOI: 10.1016/j.jpba.2004.03.009

ISSN: 0731-7085

PubMed: 15336370

WoS: 000224261500027

Scopus: 2-s2.0-4344623397
[ Google Scholar ]
3
2
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/516
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Jovanović, MS
AU  - Popović, Gordana
AU  - Kapetanović, Vera
AU  - Orlić, M
AU  - Vladimirov, S
PY  - 2004
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/516
AB  - In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid
VL  - 35
IS  - 5
SP  - 1257
EP  - 1261
DO  - 10.1016/j.jpba.2004.03.009
ER  - 
@article{
author = "Jovanović, MS and Popović, Gordana and Kapetanović, Vera and Orlić, M and Vladimirov, S",
year = "2004",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/516",
abstract = "In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid",
volume = "35",
number = "5",
pages = "1257-1261",
doi = "10.1016/j.jpba.2004.03.009"
}
Jovanović M, Popović G, Kapetanović V, Orlić M, Vladimirov S. Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid. Journal of Pharmaceutical and Biomedical Analysis. 2004;35(5):1257-1261
Jovanović, M., Popović, G., Kapetanović, V., Orlić, M.,& Vladimirov, S. (2004). Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid.
Journal of Pharmaceutical and Biomedical AnalysisElsevier Science BV, Amsterdam., 35(5), 1257-1261.
https://doi.org/10.1016/j.jpba.2004.03.009
Jovanović MS, Popović Gordana, Kapetanović Vera, Orlić M, Vladimirov S, "Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid" 35, no. 5 (2004):1257-1261,
https://doi.org/10.1016/j.jpba.2004.03.009 .

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