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dc.creatorJovanović, MS
dc.creatorPopović, Gordana
dc.creatorKapetanović, Vera
dc.creatorOrlić, M
dc.creatorVladimirov, S
dc.date.accessioned2019-09-02T10:59:02Z
dc.date.available2019-09-02T10:59:02Z
dc.date.issued2004
dc.identifier.issn0731-7085
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/516
dc.description.abstractIn order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical and Biomedical Analysis
dc.subjectiminodiacetic aciden
dc.subjectMETHYLIODIDAen
dc.subjectionization constantsen
dc.subjectpotentiometryen
dc.titleDetermination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic aciden
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКапетановић, Вера; Владимиров, С; Орлић, М; Јовановић, МС; Поповић, Гордана;
dc.citation.volume35
dc.citation.issue5
dc.citation.spage1257
dc.citation.epage1261
dc.citation.other35(5): 1257-1261
dc.citation.rankM22
dc.identifier.wos000224261500027
dc.identifier.doi10.1016/j.jpba.2004.03.009
dc.identifier.pmid15336370
dc.identifier.scopus2-s2.0-4344623397
dc.identifier.rcubconv_1570
dc.type.versionpublishedVersion


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