The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents
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The synthesis and characterization of N-[2-[[4-iodo-2,6-bis(1-methylethyl)phenyl]amino]-2-oxoethyl]-N-(carboxymethyl)glycine and N-[2-[(4-iodo-2,6-diethylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine is presented, as well as a modified and improved synthesis of N-[2-[(2,4-diiodo-6-methylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine. These compounds are new agents for hepatobiliary imaging.
Keywords:IDA analogues / halogenation / NMR spectroscopy / IR spectroscopy / mass spectroscopy
Source:Monatshefte für Chemie Chemical Monthly, 2004, 135, 8, 1009-1014
- Springer Wien, Vienna