A simple and reliable HPTLC method has been developed for simultaneous determination of antimycotics (bifonazole and econazole nitrate) and preservatives (methyl- and propylparaben) in medicinal creams. Chromatography was performed on silica gel plates with ethyl acetate-n-hexane-methanol-ammonia-diethylamine, 0.5 + 4 + 0.8 + 0.4 + 2 (v/v) as mobile phase. Chromatographic zones corresponding to spots of econazole nitrate, bifonazole, and parabens were scanned in reflectance/absorbance mode at lambda = 230, 250, and 300 nm, respectively. The method was successfully applied to simultaneous determination of the compounds in commercially available pharmaceuticals.
TY - JOUR
AU - Čakar, Mira
AU - Popović, Gordana
AU - Vladimirov, Sote
PY - 2004
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/524
AB - A simple and reliable HPTLC method has been developed for simultaneous determination of antimycotics (bifonazole and econazole nitrate) and preservatives (methyl- and propylparaben) in medicinal creams. Chromatography was performed on silica gel plates with ethyl acetate-n-hexane-methanol-ammonia-diethylamine, 0.5 + 4 + 0.8 + 0.4 + 2 (v/v) as mobile phase. Chromatographic zones corresponding to spots of econazole nitrate, bifonazole, and parabens were scanned in reflectance/absorbance mode at lambda = 230, 250, and 300 nm, respectively. The method was successfully applied to simultaneous determination of the compounds in commercially available pharmaceuticals.
PB - Springer Nature
T2 - Journal of Planar Chromatography - Modern TLC
T1 - Simultaneous HPTLC determination of imidazole antimycotics and parabens in creams
VL - 17
IS - 3
SP - 177
EP - 180
DO - 10.1556/JPC.17.2004.3.4
ER -
@article{
author = "Čakar, Mira and Popović, Gordana and Vladimirov, Sote",
year = "2004",
abstract = "A simple and reliable HPTLC method has been developed for simultaneous determination of antimycotics (bifonazole and econazole nitrate) and preservatives (methyl- and propylparaben) in medicinal creams. Chromatography was performed on silica gel plates with ethyl acetate-n-hexane-methanol-ammonia-diethylamine, 0.5 + 4 + 0.8 + 0.4 + 2 (v/v) as mobile phase. Chromatographic zones corresponding to spots of econazole nitrate, bifonazole, and parabens were scanned in reflectance/absorbance mode at lambda = 230, 250, and 300 nm, respectively. The method was successfully applied to simultaneous determination of the compounds in commercially available pharmaceuticals.",
publisher = "Springer Nature",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Simultaneous HPTLC determination of imidazole antimycotics and parabens in creams",
volume = "17",
number = "3",
pages = "177-180",
doi = "10.1556/JPC.17.2004.3.4"
}
Čakar, M., Popović, G.,& Vladimirov, S.. (2004). Simultaneous HPTLC determination of imidazole antimycotics and parabens in creams. in Journal of Planar Chromatography - Modern TLC
Springer Nature., 17(3), 177-180.
https://doi.org/10.1556/JPC.17.2004.3.4
Čakar M, Popović G, Vladimirov S. Simultaneous HPTLC determination of imidazole antimycotics and parabens in creams. in Journal of Planar Chromatography - Modern TLC. 2004;17(3):177-180.
doi:10.1556/JPC.17.2004.3.4 .
Čakar, Mira, Popović, Gordana, Vladimirov, Sote, "Simultaneous HPTLC determination of imidazole antimycotics and parabens in creams" in Journal of Planar Chromatography - Modern TLC, 17, no. 3 (2004):177-180,
https://doi.org/10.1556/JPC.17.2004.3.4 . .
