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Simultaneous HPTLC determination of imidazole antimycotics and parabens in creams

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Authors
Čakar, Mira
Popović, Gordana
Vladimirov, S
Article (Published version)
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Abstract
A simple and reliable HPTLC method has been developed for simultaneous determination of antimycotics (bifonazole and econazole nitrate) and preservatives (methyl- and propylparaben) in medicinal creams. Chromatography was performed on silica gel plates with ethyl acetate-n-hexane-methanol-ammonia-diethylamine, 0.5 + 4 + 0.8 + 0.4 + 2 (v/v) as mobile phase. Chromatographic zones corresponding to spots of econazole nitrate, bifonazole, and parabens were scanned in reflectance/absorbance mode at lambda = 230, 250, and 300 nm, respectively. The method was successfully applied to simultaneous determination of the compounds in commercially available pharmaceuticals.
Keywords:
econazole nitrate / bifonazole / parabens / HPTLC / medicinal cream
Source:
Journal of Planar Chromatography - Modern TLC, 2004, 17, 3, 177-180
Publisher:
  • Research Inst Medicinal Plants, Budakalasz

DOI: 10.1556/JPC.17.2004.3.4

ISSN: 0933-4173

WoS: 000222956100004

Scopus: 2-s2.0-4043052270
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/524
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Pharmacy

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