In vitro antioxidant activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench
Апстракт
Filipendula ulmaria (L.) Maxim. and F. vulgaris Moench are traditionally employed in the treatment of peptic ulcer and pain. The aim of present study was to estimate their antioxidant properties in order to better understand reported ethnomedicinal use. Antioxidant activity of lyophilized flower infusions (LFIs), spiraeoside (quantitatively dominant flavonoid) and referent compound Trolox® was investigated in human serum in vitro by following their ability to decrease oxidative stress produced by the addition of tert-butyl hydroperoxide. Parameters indicating protective capacity (total antioxidative status, TAS; total oxidative status, TOS; and pro-oxidant–antioxidant balance, PAB) were determined spectrophotometrically and results were expressed as percentage of the value of the same parameter in control group. All tested samples (10–160 μg/mL) concentration-dependently and significantly increased TAS (for maximum concentration, values were 190-400%) and decreased PAB (for maximum con...centration, values were 13-78%). LFIs in the applied concentration range did not significantly influence TOS, in contrast to spiraeoside which increased its values, and Trolox® which reduced TOS. Protective activity of Trolox® was more pronounced than the effect of herbal preparations and spiraeoside. The obtained results support folkloric use of F. ulmaria and F. vulgaris and indicate considerable antioxidant capacity which should be further investigated.
Извор:
13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts, 2019, 182-182Издавач:
- Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš
- Institute for Nature Conservation of Serbia
Финансирање / пројекти:
- Испитивање лековитог потенцијала биљака: морфолошка, хемијска и фармаколошка карактеризација (RS-MESTD-Basic Research (BR or ON)-173021)
Напомена:
- Saopštenje sa međunarodnog skupa štampano u izvodu (M34)
Институција/група
PharmacyTY - CONF AU - Samardžić, Stevan AU - Kotur-Stevuljević, Jelena AU - Maksimović, Zoran PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5259 AB - Filipendula ulmaria (L.) Maxim. and F. vulgaris Moench are traditionally employed in the treatment of peptic ulcer and pain. The aim of present study was to estimate their antioxidant properties in order to better understand reported ethnomedicinal use. Antioxidant activity of lyophilized flower infusions (LFIs), spiraeoside (quantitatively dominant flavonoid) and referent compound Trolox® was investigated in human serum in vitro by following their ability to decrease oxidative stress produced by the addition of tert-butyl hydroperoxide. Parameters indicating protective capacity (total antioxidative status, TAS; total oxidative status, TOS; and pro-oxidant–antioxidant balance, PAB) were determined spectrophotometrically and results were expressed as percentage of the value of the same parameter in control group. All tested samples (10–160 μg/mL) concentration-dependently and significantly increased TAS (for maximum concentration, values were 190-400%) and decreased PAB (for maximum concentration, values were 13-78%). LFIs in the applied concentration range did not significantly influence TOS, in contrast to spiraeoside which increased its values, and Trolox® which reduced TOS. Protective activity of Trolox® was more pronounced than the effect of herbal preparations and spiraeoside. The obtained results support folkloric use of F. ulmaria and F. vulgaris and indicate considerable antioxidant capacity which should be further investigated. PB - Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš PB - Institute for Nature Conservation of Serbia C3 - 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts T1 - In vitro antioxidant activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench SP - 182 EP - 182 UR - https://hdl.handle.net/21.15107/rcub_farfar_5259 ER -
@conference{ author = "Samardžić, Stevan and Kotur-Stevuljević, Jelena and Maksimović, Zoran", year = "2019", abstract = "Filipendula ulmaria (L.) Maxim. and F. vulgaris Moench are traditionally employed in the treatment of peptic ulcer and pain. The aim of present study was to estimate their antioxidant properties in order to better understand reported ethnomedicinal use. Antioxidant activity of lyophilized flower infusions (LFIs), spiraeoside (quantitatively dominant flavonoid) and referent compound Trolox® was investigated in human serum in vitro by following their ability to decrease oxidative stress produced by the addition of tert-butyl hydroperoxide. Parameters indicating protective capacity (total antioxidative status, TAS; total oxidative status, TOS; and pro-oxidant–antioxidant balance, PAB) were determined spectrophotometrically and results were expressed as percentage of the value of the same parameter in control group. All tested samples (10–160 μg/mL) concentration-dependently and significantly increased TAS (for maximum concentration, values were 190-400%) and decreased PAB (for maximum concentration, values were 13-78%). LFIs in the applied concentration range did not significantly influence TOS, in contrast to spiraeoside which increased its values, and Trolox® which reduced TOS. Protective activity of Trolox® was more pronounced than the effect of herbal preparations and spiraeoside. The obtained results support folkloric use of F. ulmaria and F. vulgaris and indicate considerable antioxidant capacity which should be further investigated.", publisher = "Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Institute for Nature Conservation of Serbia", journal = "13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts", title = "In vitro antioxidant activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench", pages = "182-182", url = "https://hdl.handle.net/21.15107/rcub_farfar_5259" }
Samardžić, S., Kotur-Stevuljević, J.,& Maksimović, Z.. (2019). In vitro antioxidant activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš., 182-182. https://hdl.handle.net/21.15107/rcub_farfar_5259
Samardžić S, Kotur-Stevuljević J, Maksimović Z. In vitro antioxidant activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts. 2019;:182-182. https://hdl.handle.net/21.15107/rcub_farfar_5259 .
Samardžić, Stevan, Kotur-Stevuljević, Jelena, Maksimović, Zoran, "In vitro antioxidant activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench" in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts (2019):182-182, https://hdl.handle.net/21.15107/rcub_farfar_5259 .