DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders
Abstract
The DNA-binding activities of compounds used as remedies can display DNA-protection, but also damaging effects in biological systems. The current review compiles literature data on DNA-binding activities of drugs widely used as remedies with different therapeutic indications. The compounds are classified according their mechanism of action: enzyme inhibitors, ion channel inhibitors, inhibitors of viral RNA replication and HIV protease and receptor agonists. DNA binding was reported for such widely used drugs as paracetamol, aspirin, metformin, statins and many others. The capability of the drug to bind DNA is sometimes coupled to genotoxic effects, but in some cases - to genome protection. Data on atoms and chemical groups involved in the drug-DNA interactions are also presented. In many cases the same atoms are involved in both interactions of the compounds with proteins and DNA.
Keywords:
Interactions with DNA / Enzyme inhibitors / Ion channel inhibitors / Inhibitors of viral RNA replication and HIV protease / Receptor agonistsSource:
Chemico-Biological Interactions, 2021, 348Publisher:
- Elsevier
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200161 (University of Belgrade, Faculty of Pharmacy) (RS-MESTD-inst-2020-200161)
DOI: 10.1016/j.cbi.2021.109638
ISSN: 0009-2797
PubMed: 34508711
WoS: 000704953200005
Scopus: 2-s2.0-85115010567
Collections
Institution/Community
PharmacyTY - JOUR AU - Muhamadejevs, Ruslans AU - Živković, Lada AU - Dzintare, Maija AU - Sjakste, Nikolajs PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5278 AB - The DNA-binding activities of compounds used as remedies can display DNA-protection, but also damaging effects in biological systems. The current review compiles literature data on DNA-binding activities of drugs widely used as remedies with different therapeutic indications. The compounds are classified according their mechanism of action: enzyme inhibitors, ion channel inhibitors, inhibitors of viral RNA replication and HIV protease and receptor agonists. DNA binding was reported for such widely used drugs as paracetamol, aspirin, metformin, statins and many others. The capability of the drug to bind DNA is sometimes coupled to genotoxic effects, but in some cases - to genome protection. Data on atoms and chemical groups involved in the drug-DNA interactions are also presented. In many cases the same atoms are involved in both interactions of the compounds with proteins and DNA. PB - Elsevier T2 - Chemico-Biological Interactions T1 - DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders VL - 348 DO - 10.1016/j.cbi.2021.109638 ER -
@article{ author = "Muhamadejevs, Ruslans and Živković, Lada and Dzintare, Maija and Sjakste, Nikolajs", year = "2021", abstract = "The DNA-binding activities of compounds used as remedies can display DNA-protection, but also damaging effects in biological systems. The current review compiles literature data on DNA-binding activities of drugs widely used as remedies with different therapeutic indications. The compounds are classified according their mechanism of action: enzyme inhibitors, ion channel inhibitors, inhibitors of viral RNA replication and HIV protease and receptor agonists. DNA binding was reported for such widely used drugs as paracetamol, aspirin, metformin, statins and many others. The capability of the drug to bind DNA is sometimes coupled to genotoxic effects, but in some cases - to genome protection. Data on atoms and chemical groups involved in the drug-DNA interactions are also presented. In many cases the same atoms are involved in both interactions of the compounds with proteins and DNA.", publisher = "Elsevier", journal = "Chemico-Biological Interactions", title = "DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders", volume = "348", doi = "10.1016/j.cbi.2021.109638" }
Muhamadejevs, R., Živković, L., Dzintare, M.,& Sjakste, N.. (2021). DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders. in Chemico-Biological Interactions Elsevier., 348. https://doi.org/10.1016/j.cbi.2021.109638
Muhamadejevs R, Živković L, Dzintare M, Sjakste N. DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders. in Chemico-Biological Interactions. 2021;348. doi:10.1016/j.cbi.2021.109638 .
Muhamadejevs, Ruslans, Živković, Lada, Dzintare, Maija, Sjakste, Nikolajs, "DNA-binding activities of compounds acting as enzyme inhibitors, ion channel blockers and receptor binders" in Chemico-Biological Interactions, 348 (2021), https://doi.org/10.1016/j.cbi.2021.109638 . .