FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Vehicle-controlled effect of urea on normal and SLS-irritated skin

Authorized Users Only
2004
Authors
Savić, Snežana
Tamburić, Slobodanka
Savić, Miroslav
Cekić, Nebojša
Milić, J.
Vuleta, G
Article (Published version)
Metadata
Show full item record
Abstract
It is known that, depending on the concentration, treatment with urea could improve skin barrier function, despite its penetration-enhancing properties. This controversial skin effect of urea has been explored systematically in this study in terms of the effect of vehicle on the performance of urea. In the first part, a series of four semi-solid emulsions with 5% (w/w) urea, varying in the type of emulsion, nature of emulsifier and polarity of oil ingredients, have been evaluated with regard to their skin hydrating and transepidermal water loss (TEWL)-modifying properties. Placebo samples were tested alongside the urea-containing ones. Two best performing moisturisers from the above were chosen for the second part of the study, in which sodium lauryl sulphate (SLS)-irritated skin was treated with both placebo and urea-containing samples. In addition to TEWL and skin hydration level, the erythema index (EI) was measured before, during and after the treatment. The results have shown that... barrier-improving and hydrating abilities of urea are bi-directional and dependent on both the type of vehicle used for its delivery and the state of skin.

Keywords:
urea / moisturiser / skin hydration / TEWL / erythema index / emulsion
Source:
International Journal of Pharmaceutics, 2004, 271, 1-2, 269-280
Publisher:
  • Elsevier Science BV, Amsterdam

DOI: 10.1016/j.ijpharm.2003.11.033

ISSN: 0378-5173

PubMed: 15129994

WoS: 000189248000028

Scopus: 2-s2.0-1142279560
[ Google Scholar ]
43
30
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/528
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Savić, Snežana
AU  - Tamburić, Slobodanka
AU  - Savić, Miroslav
AU  - Cekić, Nebojša
AU  - Milić, J.
AU  - Vuleta, G
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/528
AB  - It is known that, depending on the concentration, treatment with urea could improve skin barrier function, despite its penetration-enhancing properties. This controversial skin effect of urea has been explored systematically in this study in terms of the effect of vehicle on the performance of urea. In the first part, a series of four semi-solid emulsions with 5% (w/w) urea, varying in the type of emulsion, nature of emulsifier and polarity of oil ingredients, have been evaluated with regard to their skin hydrating and transepidermal water loss (TEWL)-modifying properties. Placebo samples were tested alongside the urea-containing ones. Two best performing moisturisers from the above were chosen for the second part of the study, in which sodium lauryl sulphate (SLS)-irritated skin was treated with both placebo and urea-containing samples. In addition to TEWL and skin hydration level, the erythema index (EI) was measured before, during and after the treatment. The results have shown that barrier-improving and hydrating abilities of urea are bi-directional and dependent on both the type of vehicle used for its delivery and the state of skin.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Vehicle-controlled effect of urea on normal and SLS-irritated skin
VL  - 271
IS  - 1-2
SP  - 269
EP  - 280
DO  - 10.1016/j.ijpharm.2003.11.033
ER  - 
@article{
author = "Savić, Snežana and Tamburić, Slobodanka and Savić, Miroslav and Cekić, Nebojša and Milić, J. and Vuleta, G",
year = "2004",
abstract = "It is known that, depending on the concentration, treatment with urea could improve skin barrier function, despite its penetration-enhancing properties. This controversial skin effect of urea has been explored systematically in this study in terms of the effect of vehicle on the performance of urea. In the first part, a series of four semi-solid emulsions with 5% (w/w) urea, varying in the type of emulsion, nature of emulsifier and polarity of oil ingredients, have been evaluated with regard to their skin hydrating and transepidermal water loss (TEWL)-modifying properties. Placebo samples were tested alongside the urea-containing ones. Two best performing moisturisers from the above were chosen for the second part of the study, in which sodium lauryl sulphate (SLS)-irritated skin was treated with both placebo and urea-containing samples. In addition to TEWL and skin hydration level, the erythema index (EI) was measured before, during and after the treatment. The results have shown that barrier-improving and hydrating abilities of urea are bi-directional and dependent on both the type of vehicle used for its delivery and the state of skin.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Vehicle-controlled effect of urea on normal and SLS-irritated skin",
volume = "271",
number = "1-2",
pages = "269-280",
doi = "10.1016/j.ijpharm.2003.11.033"
}
Savić, S., Tamburić, S., Savić, M., Cekić, N., Milić, J.,& Vuleta, G.. (2004). Vehicle-controlled effect of urea on normal and SLS-irritated skin. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 271(1-2), 269-280.
https://doi.org/10.1016/j.ijpharm.2003.11.033
Savić S, Tamburić S, Savić M, Cekić N, Milić J, Vuleta G. Vehicle-controlled effect of urea on normal and SLS-irritated skin. in International Journal of Pharmaceutics. 2004;271(1-2):269-280.
doi:10.1016/j.ijpharm.2003.11.033 .
Savić, Snežana, Tamburić, Slobodanka, Savić, Miroslav, Cekić, Nebojša, Milić, J., Vuleta, G, "Vehicle-controlled effect of urea on normal and SLS-irritated skin" in International Journal of Pharmaceutics, 271, no. 1-2 (2004):269-280,
https://doi.org/10.1016/j.ijpharm.2003.11.033 . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB