The optimal chromatographic conditions for the separation of the syn- and anti-geometric isomers of cefuroxime axetil applying RP-HPLC and micellar liquid chromatography (MLC) methods were investigated. The possibility to separate diastereoisomers of syn- and anti-cefuroxime axetil was observed. Investigations were performed using three columns, two classical silicas and one with hybrid particle technology. Three aqueous-organic and one micellar mobile phases were used. The best results were achieved using micellar mobile phase. Optimization study was performed using different micellar mobile phases. MLC method is sensitive and applicable in purity and stability testing.
TY - JOUR
AU - Živanović, L
AU - Ivanović, I
AU - Vladimirov, S
AU - Zečević, Mira
PY - 2004
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/535
AB - The optimal chromatographic conditions for the separation of the syn- and anti-geometric isomers of cefuroxime axetil applying RP-HPLC and micellar liquid chromatography (MLC) methods were investigated. The possibility to separate diastereoisomers of syn- and anti-cefuroxime axetil was observed. Investigations were performed using three columns, two classical silicas and one with hybrid particle technology. Three aqueous-organic and one micellar mobile phases were used. The best results were achieved using micellar mobile phase. Optimization study was performed using different micellar mobile phases. MLC method is sensitive and applicable in purity and stability testing.
PB - Elsevier Science BV, Amsterdam
T2 - Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
T1 - Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer
VL - 800
IS - 1-2
SP - 175
EP - 179
DO - 10.1016/j.jchromb.2003.08.046
ER -
@article{
author = "Živanović, L and Ivanović, I and Vladimirov, S and Zečević, Mira",
year = "2004",
abstract = "The optimal chromatographic conditions for the separation of the syn- and anti-geometric isomers of cefuroxime axetil applying RP-HPLC and micellar liquid chromatography (MLC) methods were investigated. The possibility to separate diastereoisomers of syn- and anti-cefuroxime axetil was observed. Investigations were performed using three columns, two classical silicas and one with hybrid particle technology. Three aqueous-organic and one micellar mobile phases were used. The best results were achieved using micellar mobile phase. Optimization study was performed using different micellar mobile phases. MLC method is sensitive and applicable in purity and stability testing.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences",
title = "Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer",
volume = "800",
number = "1-2",
pages = "175-179",
doi = "10.1016/j.jchromb.2003.08.046"
}
Živanović, L., Ivanović, I., Vladimirov, S.,& Zečević, M.. (2004). Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer. in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
Elsevier Science BV, Amsterdam., 800(1-2), 175-179.
https://doi.org/10.1016/j.jchromb.2003.08.046
Živanović L, Ivanović I, Vladimirov S, Zečević M. Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer. in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 2004;800(1-2):175-179.
doi:10.1016/j.jchromb.2003.08.046 .
Živanović, L, Ivanović, I, Vladimirov, S, Zečević, Mira, "Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer" in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 800, no. 1-2 (2004):175-179,
https://doi.org/10.1016/j.jchromb.2003.08.046 . .
