Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer
Samo za registrovane korisnike
2004
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The optimal chromatographic conditions for the separation of the syn- and anti-geometric isomers of cefuroxime axetil applying RP-HPLC and micellar liquid chromatography (MLC) methods were investigated. The possibility to separate diastereoisomers of syn- and anti-cefuroxime axetil was observed. Investigations were performed using three columns, two classical silicas and one with hybrid particle technology. Three aqueous-organic and one micellar mobile phases were used. The best results were achieved using micellar mobile phase. Optimization study was performed using different micellar mobile phases. MLC method is sensitive and applicable in purity and stability testing.
Ključne reči:
optimization / cefuroxime axetil / anti-cefuroxime axetilIzvor:
Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2004, 800, 1-2, 175-179Izdavač:
- Elsevier Science BV, Amsterdam
DOI: 10.1016/j.jchromb.2003.08.046
ISSN: 1570-0232
PubMed: 14698252
WoS: 000187954500024
Scopus: 2-s2.0-0346155970
Institucija/grupa
PharmacyTY - JOUR AU - Živanović, L AU - Ivanović, I AU - Vladimirov, S AU - Zečević, Mira PY - 2004 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/535 AB - The optimal chromatographic conditions for the separation of the syn- and anti-geometric isomers of cefuroxime axetil applying RP-HPLC and micellar liquid chromatography (MLC) methods were investigated. The possibility to separate diastereoisomers of syn- and anti-cefuroxime axetil was observed. Investigations were performed using three columns, two classical silicas and one with hybrid particle technology. Three aqueous-organic and one micellar mobile phases were used. The best results were achieved using micellar mobile phase. Optimization study was performed using different micellar mobile phases. MLC method is sensitive and applicable in purity and stability testing. PB - Elsevier Science BV, Amsterdam T2 - Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences T1 - Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer VL - 800 IS - 1-2 SP - 175 EP - 179 DO - 10.1016/j.jchromb.2003.08.046 ER -
@article{ author = "Živanović, L and Ivanović, I and Vladimirov, S and Zečević, Mira", year = "2004", abstract = "The optimal chromatographic conditions for the separation of the syn- and anti-geometric isomers of cefuroxime axetil applying RP-HPLC and micellar liquid chromatography (MLC) methods were investigated. The possibility to separate diastereoisomers of syn- and anti-cefuroxime axetil was observed. Investigations were performed using three columns, two classical silicas and one with hybrid particle technology. Three aqueous-organic and one micellar mobile phases were used. The best results were achieved using micellar mobile phase. Optimization study was performed using different micellar mobile phases. MLC method is sensitive and applicable in purity and stability testing.", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences", title = "Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer", volume = "800", number = "1-2", pages = "175-179", doi = "10.1016/j.jchromb.2003.08.046" }
Živanović, L., Ivanović, I., Vladimirov, S.,& Zečević, M.. (2004). Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer. in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences Elsevier Science BV, Amsterdam., 800(1-2), 175-179. https://doi.org/10.1016/j.jchromb.2003.08.046
Živanović L, Ivanović I, Vladimirov S, Zečević M. Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer. in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 2004;800(1-2):175-179. doi:10.1016/j.jchromb.2003.08.046 .
Živanović, L, Ivanović, I, Vladimirov, S, Zečević, Mira, "Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer" in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 800, no. 1-2 (2004):175-179, https://doi.org/10.1016/j.jchromb.2003.08.046 . .