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dc.creatorŽivanović, L
dc.creatorIvanović, I
dc.creatorVladimirov, S
dc.creatorZečević, Mira
dc.date.accessioned2019-09-02T10:59:30Z
dc.date.available2019-09-02T10:59:30Z
dc.date.issued2004
dc.identifier.issn1570-0232
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/535
dc.description.abstractThe optimal chromatographic conditions for the separation of the syn- and anti-geometric isomers of cefuroxime axetil applying RP-HPLC and micellar liquid chromatography (MLC) methods were investigated. The possibility to separate diastereoisomers of syn- and anti-cefuroxime axetil was observed. Investigations were performed using three columns, two classical silicas and one with hybrid particle technology. Three aqueous-organic and one micellar mobile phases were used. The best results were achieved using micellar mobile phase. Optimization study was performed using different micellar mobile phases. MLC method is sensitive and applicable in purity and stability testing.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
dc.subjectoptimizationen
dc.subjectcefuroxime axetilen
dc.subjectanti-cefuroxime axetilen
dc.titleInvestigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomeren
dc.typearticle
dc.rights.licenseARR
dcterms.abstractИвановић, И; Живановић, Л; Зечевић, Мира; Владимиров, С;
dc.citation.volume800
dc.citation.issue1-2
dc.citation.spage175
dc.citation.epage179
dc.citation.other800(1-2): 175-179
dc.citation.rankM21
dc.identifier.wos000187954500024
dc.identifier.doi10.1016/j.jchromb.2003.08.046
dc.identifier.pmid14698252
dc.identifier.scopus2-s2.0-0346155970
dc.identifier.rcubconv_1460
dc.type.versionpublishedVersion


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