Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics
Само за регистроване кориснике
2020
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The physical chitosan hydrogel, obtained by ionic gelation in lactic acid solution, was combined with biocompatible oil-in-water microemulsion with ibuprofen, to prepare composite hydrogels with 0.25–1% of the polymer and 5% of the drug. The electrical conductivity measurement, photon correlation spectroscopy (PCS), and rheological analysis showed that the composite hydrogels comprise oil nanodroplets (16.21–22.56 nm) embedded within pseudoplastic chitosan hydrogel. In vitro ibuprofen release was sustained for 12 h and followed zero-order kinetics. pH values of the composite hydrogels were in the range of 4.80–5.27, thus physiologically acceptable. The formulation containing 0.5% chitosan enabled the maximum drug release rate of 239.25 μgh−1cm−2 as well as cohesiveness (154.958 ± 0.731 g*s) higher than hardness (13.546 ± 0.065 g) and adhesiveness (−12.042 ± 1.161 g*s), so textural properties were suitable for application along skin surface, without spillage, and for easy removal. This ...is the first study in which the composite chitosan hydrogels with ibuprofen were formulated by combining the chitosan hydrogel prepared without harmful chemical crosslinkers and low viscosity oil-in-water microemulsion, and the preclinical characterization of their biopharmaceutical aspect and textural characterization, that is of key importance in improving the patient’s compliance, were performed.
Кључне речи:
Chitosan hydrogels / microemulsion / photon correlation spectroscopy / rheological analysis / ibuprofen / sustained releaseИзвор:
Pharmaceutical Development and Technology, 2020, 25, 3, 332-339Издавач:
- Taylor & Francis
Финансирање / пројекти:
- Развој нових инкапсулационих и ензимских технологија за производњу биокатализатора и биолошки активних компонената хране у циљу повећања њене конкурентности, квалитета и безбедности (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
DOI: 10.1080/10837450.2019.1701495
ISSN: 1083-7450
WoS: 000502220500001
Scopus: 2-s2.0-85076400165
Институција/група
PharmacyTY - JOUR AU - Đekić, Ljiljana AU - Martinović, Martina AU - Ćirić, Ana AU - Fraj, Jadranka PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5372 AB - The physical chitosan hydrogel, obtained by ionic gelation in lactic acid solution, was combined with biocompatible oil-in-water microemulsion with ibuprofen, to prepare composite hydrogels with 0.25–1% of the polymer and 5% of the drug. The electrical conductivity measurement, photon correlation spectroscopy (PCS), and rheological analysis showed that the composite hydrogels comprise oil nanodroplets (16.21–22.56 nm) embedded within pseudoplastic chitosan hydrogel. In vitro ibuprofen release was sustained for 12 h and followed zero-order kinetics. pH values of the composite hydrogels were in the range of 4.80–5.27, thus physiologically acceptable. The formulation containing 0.5% chitosan enabled the maximum drug release rate of 239.25 μgh−1cm−2 as well as cohesiveness (154.958 ± 0.731 g*s) higher than hardness (13.546 ± 0.065 g) and adhesiveness (−12.042 ± 1.161 g*s), so textural properties were suitable for application along skin surface, without spillage, and for easy removal. This is the first study in which the composite chitosan hydrogels with ibuprofen were formulated by combining the chitosan hydrogel prepared without harmful chemical crosslinkers and low viscosity oil-in-water microemulsion, and the preclinical characterization of their biopharmaceutical aspect and textural characterization, that is of key importance in improving the patient’s compliance, were performed. PB - Taylor & Francis T2 - Pharmaceutical Development and Technology T1 - Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics VL - 25 IS - 3 SP - 332 EP - 339 DO - 10.1080/10837450.2019.1701495 ER -
@article{ author = "Đekić, Ljiljana and Martinović, Martina and Ćirić, Ana and Fraj, Jadranka", year = "2020", abstract = "The physical chitosan hydrogel, obtained by ionic gelation in lactic acid solution, was combined with biocompatible oil-in-water microemulsion with ibuprofen, to prepare composite hydrogels with 0.25–1% of the polymer and 5% of the drug. The electrical conductivity measurement, photon correlation spectroscopy (PCS), and rheological analysis showed that the composite hydrogels comprise oil nanodroplets (16.21–22.56 nm) embedded within pseudoplastic chitosan hydrogel. In vitro ibuprofen release was sustained for 12 h and followed zero-order kinetics. pH values of the composite hydrogels were in the range of 4.80–5.27, thus physiologically acceptable. The formulation containing 0.5% chitosan enabled the maximum drug release rate of 239.25 μgh−1cm−2 as well as cohesiveness (154.958 ± 0.731 g*s) higher than hardness (13.546 ± 0.065 g) and adhesiveness (−12.042 ± 1.161 g*s), so textural properties were suitable for application along skin surface, without spillage, and for easy removal. This is the first study in which the composite chitosan hydrogels with ibuprofen were formulated by combining the chitosan hydrogel prepared without harmful chemical crosslinkers and low viscosity oil-in-water microemulsion, and the preclinical characterization of their biopharmaceutical aspect and textural characterization, that is of key importance in improving the patient’s compliance, were performed.", publisher = "Taylor & Francis", journal = "Pharmaceutical Development and Technology", title = "Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics", volume = "25", number = "3", pages = "332-339", doi = "10.1080/10837450.2019.1701495" }
Đekić, L., Martinović, M., Ćirić, A.,& Fraj, J.. (2020). Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics. in Pharmaceutical Development and Technology Taylor & Francis., 25(3), 332-339. https://doi.org/10.1080/10837450.2019.1701495
Đekić L, Martinović M, Ćirić A, Fraj J. Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics. in Pharmaceutical Development and Technology. 2020;25(3):332-339. doi:10.1080/10837450.2019.1701495 .
Đekić, Ljiljana, Martinović, Martina, Ćirić, Ana, Fraj, Jadranka, "Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics" in Pharmaceutical Development and Technology, 25, no. 3 (2020):332-339, https://doi.org/10.1080/10837450.2019.1701495 . .