Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics
Abstract
The physical chitosan hydrogel, obtained by ionic gelation in lactic acid solution, was combined with biocompatible oil-in-water microemulsion with ibuprofen, to prepare composite hydrogels with 0.25–1% of the polymer and 5% of the drug. The electrical conductivity measurement, photon correlation spectroscopy (PCS), and rheological analysis showed that the composite hydrogels comprise oil nanodroplets (16.21–22.56 nm) embedded within pseudoplastic chitosan hydrogel. In vitro ibuprofen release was sustained for 12 h and followed zero-order kinetics. pH values of the composite hydrogels were in the range of 4.80–5.27, thus physiologically acceptable. The formulation containing 0.5% chitosan enabled the maximum drug release rate of 239.25 μgh−1cm−2 as well as cohesiveness (154.958 ± 0.731 g*s) higher than hardness (13.546 ± 0.065 g) and adhesiveness (−12.042 ± 1.161 g*s), so textural properties were suitable for application along skin surface, without spillage, and for easy removal. This ...is the first study in which the composite chitosan hydrogels with ibuprofen were formulated by combining the chitosan hydrogel prepared without harmful chemical crosslinkers and low viscosity oil-in-water microemulsion, and the preclinical characterization of their biopharmaceutical aspect and textural characterization, that is of key importance in improving the patient’s compliance, were performed.
Keywords:
Chitosan hydrogels / microemulsion / photon correlation spectroscopy / rheological analysis / ibuprofen / sustained releaseSource:
Pharmaceutical Development and Technology, 2020, 25, 3, 332-339Publisher:
- Taylor & Francis
Funding / projects:
- Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
DOI: 10.1080/10837450.2019.1701495
ISSN: 1083-7450
WoS: 000502220500001
Scopus: 2-s2.0-85076400165
Collections
Institution/Community
PharmacyTY - JOUR AU - Đekić, Ljiljana AU - Martinović, Martina AU - Ćirić, Ana AU - Fraj, Jadranka PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5372 AB - The physical chitosan hydrogel, obtained by ionic gelation in lactic acid solution, was combined with biocompatible oil-in-water microemulsion with ibuprofen, to prepare composite hydrogels with 0.25–1% of the polymer and 5% of the drug. The electrical conductivity measurement, photon correlation spectroscopy (PCS), and rheological analysis showed that the composite hydrogels comprise oil nanodroplets (16.21–22.56 nm) embedded within pseudoplastic chitosan hydrogel. In vitro ibuprofen release was sustained for 12 h and followed zero-order kinetics. pH values of the composite hydrogels were in the range of 4.80–5.27, thus physiologically acceptable. The formulation containing 0.5% chitosan enabled the maximum drug release rate of 239.25 μgh−1cm−2 as well as cohesiveness (154.958 ± 0.731 g*s) higher than hardness (13.546 ± 0.065 g) and adhesiveness (−12.042 ± 1.161 g*s), so textural properties were suitable for application along skin surface, without spillage, and for easy removal. This is the first study in which the composite chitosan hydrogels with ibuprofen were formulated by combining the chitosan hydrogel prepared without harmful chemical crosslinkers and low viscosity oil-in-water microemulsion, and the preclinical characterization of their biopharmaceutical aspect and textural characterization, that is of key importance in improving the patient’s compliance, were performed. PB - Taylor & Francis T2 - Pharmaceutical Development and Technology T1 - Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics VL - 25 IS - 3 SP - 332 EP - 339 DO - 10.1080/10837450.2019.1701495 ER -
@article{ author = "Đekić, Ljiljana and Martinović, Martina and Ćirić, Ana and Fraj, Jadranka", year = "2020", abstract = "The physical chitosan hydrogel, obtained by ionic gelation in lactic acid solution, was combined with biocompatible oil-in-water microemulsion with ibuprofen, to prepare composite hydrogels with 0.25–1% of the polymer and 5% of the drug. The electrical conductivity measurement, photon correlation spectroscopy (PCS), and rheological analysis showed that the composite hydrogels comprise oil nanodroplets (16.21–22.56 nm) embedded within pseudoplastic chitosan hydrogel. In vitro ibuprofen release was sustained for 12 h and followed zero-order kinetics. pH values of the composite hydrogels were in the range of 4.80–5.27, thus physiologically acceptable. The formulation containing 0.5% chitosan enabled the maximum drug release rate of 239.25 μgh−1cm−2 as well as cohesiveness (154.958 ± 0.731 g*s) higher than hardness (13.546 ± 0.065 g) and adhesiveness (−12.042 ± 1.161 g*s), so textural properties were suitable for application along skin surface, without spillage, and for easy removal. This is the first study in which the composite chitosan hydrogels with ibuprofen were formulated by combining the chitosan hydrogel prepared without harmful chemical crosslinkers and low viscosity oil-in-water microemulsion, and the preclinical characterization of their biopharmaceutical aspect and textural characterization, that is of key importance in improving the patient’s compliance, were performed.", publisher = "Taylor & Francis", journal = "Pharmaceutical Development and Technology", title = "Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics", volume = "25", number = "3", pages = "332-339", doi = "10.1080/10837450.2019.1701495" }
Đekić, L., Martinović, M., Ćirić, A.,& Fraj, J.. (2020). Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics. in Pharmaceutical Development and Technology Taylor & Francis., 25(3), 332-339. https://doi.org/10.1080/10837450.2019.1701495
Đekić L, Martinović M, Ćirić A, Fraj J. Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics. in Pharmaceutical Development and Technology. 2020;25(3):332-339. doi:10.1080/10837450.2019.1701495 .
Đekić, Ljiljana, Martinović, Martina, Ćirić, Ana, Fraj, Jadranka, "Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics" in Pharmaceutical Development and Technology, 25, no. 3 (2020):332-339, https://doi.org/10.1080/10837450.2019.1701495 . .