Sinteza i antikancerski potencijal 4-azolilkumarina

Abstract

Kumarini su heterociklična jedinjenja veoma rasprostranjen u prirodi. Kao privilegovana struktura, ovaj molekul se nalazi i u velikom broju sintetskih derivata sa značajnom biološkom aktivnošću. Posebno su interesantni hibridi koji sadrže dve farmakofore, od kojih je jedna kumarin. Cilj ovog istraživanja bio je sinteza serije jednostavnih novih 4-azolil kumarina i evaluacija njihove in vitro citotoksičnosti prema humanim kancerskim ćelijskim linijama HeLa, K562, MCF-7 i MDA-MB- 453.

Coumarins are heterocyclic compounds widely distributed in nature. As a privileged structure, coumarin is also found in a large number of synthetic molecules with important biological activity. Particularly interesting compounds are coumarin-containing hybrids, compounds with two or more pharmacophores. The aim of this work was preparation of simple novel azolyl-coumarin hybrids and evaluation of their cytotoxic effect on human cancer cells, HeLa, K562, MDA-MB-453 and MCF-7.