May thirteen weeks of octacosanol supplementation affect prooxidant-antioxidant balance in patients on atorvastatin therapy
Аутори
Zrnić-Ćirić, MilicaKotur-Stevuljević, Jelena
Baralić, Ivana
Đorđević, Brižita
Stanković, Ivan
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Statins reduce the risk of cardiovascular disease mainly due to cholesterol reduction, but also
pleiotropic effects are present. Co-administration of statins with bioactive molecules may
obtain a synergistic benefit. The aim of this randomized, placebo-controlled, double-blind
study was to investigate whether 13-week long supplementation of policosanol affected
antioxidant status and markers of oxidative stress in patients on atorvastatin therapy. Eighty-
seven patients aged 40–80 years on chronic (>4 months) atorvastatin therapy (20 mg) were
randomly allocated to policosanol (n=42) or placebo (n=45). At baseline, after 8 and 13 weeks,
markers of oxidative stress and antioxidant defence include total antioxidant status (TAS), total
oxidant status (TOS), advanced oxidation protein products (AOPP) and activity of superoxide
dismutase (SOD) were measured. Creatinine phosphokinase and hepatic enzymes were the
main safety endpoints. The mean age of the patients was 62.6 ± 0.8 year...s. Patients in
supplemented group had higher TAS and TOS levels 1640 (963–1752) vs 927 (481–1305),
[μmol/L], p < 0.001 and 18 (13––20) vs 6 (5–11), [μmol/L], p < 0.001], respectively, compared
to baseline. In placebo group, subjects had also higher TAS and TOS levels after 13-week
compared to baseline. SOD and AOPP were not influenced by the intervention. The
investigated supplement possessed a good safety profile. Combination of policosanol with
atorvastatin may be useful in an attempt to avoid potential adverse effects associated with
statins. 13-week supplementation was not sufficient to induce remarkably changes in SOD and
AOPP. TAS and TOS were increased in both groups.
Извор:
Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade, 2020, 15-15Издавач:
- University of Belgrade, Belgrade, Serbia
Напомена:
- Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade, March 2-3, 2020
Институција/група
PharmacyTY - CONF AU - Zrnić-Ćirić, Milica AU - Kotur-Stevuljević, Jelena AU - Baralić, Ivana AU - Đorđević, Brižita AU - Stanković, Ivan PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5395 AB - Statins reduce the risk of cardiovascular disease mainly due to cholesterol reduction, but also pleiotropic effects are present. Co-administration of statins with bioactive molecules may obtain a synergistic benefit. The aim of this randomized, placebo-controlled, double-blind study was to investigate whether 13-week long supplementation of policosanol affected antioxidant status and markers of oxidative stress in patients on atorvastatin therapy. Eighty- seven patients aged 40–80 years on chronic (>4 months) atorvastatin therapy (20 mg) were randomly allocated to policosanol (n=42) or placebo (n=45). At baseline, after 8 and 13 weeks, markers of oxidative stress and antioxidant defence include total antioxidant status (TAS), total oxidant status (TOS), advanced oxidation protein products (AOPP) and activity of superoxide dismutase (SOD) were measured. Creatinine phosphokinase and hepatic enzymes were the main safety endpoints. The mean age of the patients was 62.6 ± 0.8 years. Patients in supplemented group had higher TAS and TOS levels 1640 (963–1752) vs 927 (481–1305), [μmol/L], p < 0.001 and 18 (13––20) vs 6 (5–11), [μmol/L], p < 0.001], respectively, compared to baseline. In placebo group, subjects had also higher TAS and TOS levels after 13-week compared to baseline. SOD and AOPP were not influenced by the intervention. The investigated supplement possessed a good safety profile. Combination of policosanol with atorvastatin may be useful in an attempt to avoid potential adverse effects associated with statins. 13-week supplementation was not sufficient to induce remarkably changes in SOD and AOPP. TAS and TOS were increased in both groups. PB - University of Belgrade, Belgrade, Serbia C3 - Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade T1 - May thirteen weeks of octacosanol supplementation affect prooxidant-antioxidant balance in patients on atorvastatin therapy SP - 15 EP - 15 UR - https://hdl.handle.net/21.15107/rcub_farfar_5395 ER -
@conference{ author = "Zrnić-Ćirić, Milica and Kotur-Stevuljević, Jelena and Baralić, Ivana and Đorđević, Brižita and Stanković, Ivan", year = "2020", abstract = "Statins reduce the risk of cardiovascular disease mainly due to cholesterol reduction, but also pleiotropic effects are present. Co-administration of statins with bioactive molecules may obtain a synergistic benefit. The aim of this randomized, placebo-controlled, double-blind study was to investigate whether 13-week long supplementation of policosanol affected antioxidant status and markers of oxidative stress in patients on atorvastatin therapy. Eighty- seven patients aged 40–80 years on chronic (>4 months) atorvastatin therapy (20 mg) were randomly allocated to policosanol (n=42) or placebo (n=45). At baseline, after 8 and 13 weeks, markers of oxidative stress and antioxidant defence include total antioxidant status (TAS), total oxidant status (TOS), advanced oxidation protein products (AOPP) and activity of superoxide dismutase (SOD) were measured. Creatinine phosphokinase and hepatic enzymes were the main safety endpoints. The mean age of the patients was 62.6 ± 0.8 years. Patients in supplemented group had higher TAS and TOS levels 1640 (963–1752) vs 927 (481–1305), [μmol/L], p < 0.001 and 18 (13––20) vs 6 (5–11), [μmol/L], p < 0.001], respectively, compared to baseline. In placebo group, subjects had also higher TAS and TOS levels after 13-week compared to baseline. SOD and AOPP were not influenced by the intervention. The investigated supplement possessed a good safety profile. Combination of policosanol with atorvastatin may be useful in an attempt to avoid potential adverse effects associated with statins. 13-week supplementation was not sufficient to induce remarkably changes in SOD and AOPP. TAS and TOS were increased in both groups.", publisher = "University of Belgrade, Belgrade, Serbia", journal = "Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade", title = "May thirteen weeks of octacosanol supplementation affect prooxidant-antioxidant balance in patients on atorvastatin therapy", pages = "15-15", url = "https://hdl.handle.net/21.15107/rcub_farfar_5395" }
Zrnić-Ćirić, M., Kotur-Stevuljević, J., Baralić, I., Đorđević, B.,& Stanković, I.. (2020). May thirteen weeks of octacosanol supplementation affect prooxidant-antioxidant balance in patients on atorvastatin therapy. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade University of Belgrade, Belgrade, Serbia., 15-15. https://hdl.handle.net/21.15107/rcub_farfar_5395
Zrnić-Ćirić M, Kotur-Stevuljević J, Baralić I, Đorđević B, Stanković I. May thirteen weeks of octacosanol supplementation affect prooxidant-antioxidant balance in patients on atorvastatin therapy. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade. 2020;:15-15. https://hdl.handle.net/21.15107/rcub_farfar_5395 .
Zrnić-Ćirić, Milica, Kotur-Stevuljević, Jelena, Baralić, Ivana, Đorđević, Brižita, Stanković, Ivan, "May thirteen weeks of octacosanol supplementation affect prooxidant-antioxidant balance in patients on atorvastatin therapy" in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade (2020):15-15, https://hdl.handle.net/21.15107/rcub_farfar_5395 .