Show simple item record

Spektrofotometrijsko određivanje Bifonazola i Klotrimazola u losionima Bicutrin® i Canesten®

dc.creatorČakar, Mira
dc.creatorPopović, Gordana
dc.date.accessioned2019-09-02T10:59:43Z
dc.date.available2019-09-02T10:59:43Z
dc.date.issued2004
dc.identifier.issn0004-1963
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/543
dc.description.abstractA direct spectrophotometric method for the determination of bifonazole and clotrimazole in commercial lotions Bicutrin® and Canesten®, respectively, has been developed. The determinations were performed in a 0.1 M HCl solution at 257 nm (bifonazole) and 225 nm (clotrimazole). A calibration curves were obtained in the concentration range 1.5 -15.0 µg/ml and 2.5 - 25.0 µg/ml for bifonazole and clotrimazole, respectively, with correlation coefficient is 0.9999 for both curve. The accuracy and reproducibility of the method was checked by analyzing solutions of three different concentrations of bifonazole (recovery 98.7 - 99.7 % ; RSD 0.60-1.55 % ) and clotrimazole (recovery 98.3 - 99.1 % ; RSD 0.96 - 1.67 % ). The method proposed in this study is fast, accurate and reproductive. It enables the direct spectrophotometric determination of bifonazole and clotrimazole in lotions without previous isolation. The simplicity and low cost can be advantage of this method.en
dc.description.abstractU radu je predložena direktna spektrofotometrijska metoda za određivanje antimikotika bifonazola i klotrimazola u losionima Bicutrin®, odnosno Canesten®. Određivanja su vršena u 0,1 M HCl na talasnoj dužini 257 nm (bifonazol), odnosno 225 nm (klotrimazol). Kalibraciona kriva dobijena je u opsegu koncentracija bifonazola 1,5-15 µg/ml, i klotrimazola 2,5-25 µg/ml, sa koeficientom korelacije 0,9999 za obe krive. Tačnost i reproduktivnost metode proverena je analizom rastvora tri različite koncentracije bifonazola („recovery” 98,7-99,7 % ; RSD 0,60-1,55 % ) i klotrimazola („recovery” 98,3-99,1 % ; RSD 0,96-1,67 % ). Dobijeni rezultati ukazuju na tačnost i reproduktivnost predložene spektrofotometrijske metode, kao i na mogućnost direknog spektrofotometrijskog određivanja bifonazola i klotrimazola u odgovarajućim losionima bez prethodnog izolovanja.sr
dc.publisherSavez farmaceutskih udruženja Srbije, Beograd
dc.rightsopenAccess
dc.sourceArhiv za farmaciju
dc.subjectbifonazoleen
dc.subjectclotrimazoleen
dc.subjectUV spectrophotometric determinationen
dc.subjectlotionen
dc.subjectbifonazolsr
dc.subjectklotrimazolsr
dc.subjectUV spektrofotometrijsko određivanjesr
dc.subjectlosionsr
dc.titleSpectrophotometric determination of Bifonazole and Clotrimazole in lotions Bicutrin® and Canesten®en
dc.titleSpektrofotometrijsko određivanje Bifonazola i Klotrimazola u losionima Bicutrin® i Canesten®sr
dc.typearticle
dc.rights.licenseBY-SA
dcterms.abstractПоповић, Гордана; Чакар, Мира; Спектрофотометријско одређивање Бифоназола и Клотримазола у лосионима Бицутрин® и Цанестен®; Спектрофотометријско одређивање Бифоназола и Клотримазола у лосионима Бицутрин® и Цанестен®;
dc.citation.volume54
dc.citation.issue1-2
dc.citation.spage1
dc.citation.epage13
dc.citation.other54(1-2): 1-13
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/2056/541.pdf
dc.identifier.rcubconv_141
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record