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dc.creatorIvanović, D
dc.creatorMedenica, Mirjana
dc.creatorJančić, Biljana
dc.creatorMalenović, Anđelija
dc.date.accessioned2019-09-02T10:59:45Z
dc.date.available2019-09-02T10:59:45Z
dc.date.issued2004
dc.identifier.issn1570-0232
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/544
dc.description.abstractThe reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for the simultaneous determination of imatinib mesylate and of the impurity product in Glivec(R) capsules (Novartis, Switzerland). Separations were performed on a X Terra(TM) 150 mm 4.6 mm, 5 mum particle size column at 25 degreesC. The mobile phase was a mixture of methanol-water-triethylamine (25:74: 1, v/v/v) with flow rate of 1.0 ml min(-1). pH value of water-triethylamine (TEA) was adjusted to 2.4 with orthophosphoric acid before adding of methanol. UV detection was performed at 267 nm. Acetaminophen was used as an internal standard. The method was validated statistically for its selectivity, linearity, precision, accuracy and robustness. Due to its speed and accuracy, the method may be used for quality control analyses.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
dc.subjectimatinib mesylateen
dc.titleReversed-phase liquid chromatography analysis of imatinib mesylate and impurity product in Glivec (R) capsulesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМеденица, Мирјана; Ивановић, Д; Маленовић, Aнђелија; Јанчић, Биљана;
dc.citation.volume800
dc.citation.issue1-2
dc.citation.spage253
dc.citation.epage258
dc.citation.other800(1-2): 253-258
dc.citation.rankM21
dc.identifier.wos000187954500034
dc.identifier.doi10.1016/j.jchromb.2003.10.018
dc.identifier.pmid14698262
dc.identifier.scopus2-s2.0-0347415745
dc.identifier.rcubconv_1461
dc.type.versionpublishedVersion


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