The pharmacokinetics of drugs for gastrointestinal diseases important for the rational pharmacotherapy

Abstract

Although much progress in the pharmacotherapeutic treatment of gastrointestinal diseases has been made during recent years, a lot of research is still needed in order to elucidate exact disease mechanisms, and to develop corresponding drugs. From the treatmens of Helicobacter pylori infections which are still far from ideal, through pharmacotherapy of irritable bowel syndrome which is not satisfactory, to directon for recognition and integration of important factors in pharmacotherapy of inflammatory bowel disease (genetic, infectious, immunologic and inflammatory), there are many open questions. The pharmacotherapy research today goes towards development of new drugs and vaccines based on the discovery of new receptors, appreciation of influence of important general and individual factors of diseases, as well as preventive and pharmacoeconomic treatment considerations. Pharmacokinetic principles considerations are necessary within all the pharmacotherapy ways, in order to develop drugs and drug products of better pharmacokinetics, and to provide individualized, effective and safe, as well as economic (rational) pharmacotherapy.

Iako je tokom poslednjih godina učinjen veliki progres u farmakoterapiji gastrointestinalnih oboljenja, još uvek je potrebno mnogo istraživanja da bi se razjasnili egzaktni mehanizmi bolesti i razvili odgovarajući lekovi. Od tretmana infekcije sa Helicobacter pylori, koji se još uvek smatraju daleko od idealnih, preko farmakoterapije iritabilnog sindroma creva koja je nezadovoljavajuća, do usmeravanja na uvažavanje faktora značajnih za farmakoterapiju inflamatornog oboljenja creva (genetički, infektivni, imunološki i inflamatorni), još je mnogo otvorenih pitanja. Farmakoterapijska istraživanja danas idu u pravcu razvoja novih lekova i vakcina zasnovanih na otkriću novih receptora, uvažavanju uticaja značajnih opštih i individualnih faktora bolesti, kao i preventivnim i farmakoekonomskim razmatranjima lečenja. Razmatranje farmakokinetičkih principa je potrebno u okviru svih farmakoterapijskih pravaca, u cilju iznalaženja lekova i preparata bolje farmakokinetike i sprovođenja individualizovane, efikasne i bezbedne, kao i ekonomične (racionalne) farmakoterapije.