Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine
Само за регистроване кориснике
2004
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Abstract
It was found that the reduction of the cefpodoxime proxetil (CP) molecule is strongly influenced by the adsorption. The adsorptive
properties of CP were investigated in order to achieve an increase sensitivity of its determination. Validated adsorptive stripping differential
pulse voltammetry is applied for the determination of low concentration of CP at pH 3.5 and 9.0 where the best pronounced adsorption effects
were observed. The linearity of the calibration curves were achieved from 1 × 10−8 to 1 × 10−7 M with limit of detection (LOD) of 6.3×10−9
and 7.1 × 10−9 M, and limit of quantification (LOQ) of 2.1 × 10−8 and 2.3 × 10−8 M, at pH 3.5 and 9.0, respectively. The proposed method
was tested for CP determination in spiked urine samples, enabling determination of low concentrations of CP.
Кључне речи:
Cefpodoxime proxetil / Adsorptive stripping voltammetry / Urine determinationИзвор:
Journal of Pharmaceutical and Biomedical Analysis, 2004, 36, 4, 899-993Издавач:
- Elsevier B.V.
Финансирање / пројекти:
- Ministry of Science, Technologies and development of Republic of Serbia (Project No. 1458)
DOI: 10.1016/j.jpba.2004.08.035
ISSN: 0731-7085
PubMed: 15533687
WoS: 000225530100029
Scopus: 2-s2.0-7944237905
Институција/група
PharmacyTY - JOUR AU - Aleksić, Mara AU - Ilić, Miloš AU - Kapetanović, Vera PY - 2004 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5467 AB - Abstract It was found that the reduction of the cefpodoxime proxetil (CP) molecule is strongly influenced by the adsorption. The adsorptive properties of CP were investigated in order to achieve an increase sensitivity of its determination. Validated adsorptive stripping differential pulse voltammetry is applied for the determination of low concentration of CP at pH 3.5 and 9.0 where the best pronounced adsorption effects were observed. The linearity of the calibration curves were achieved from 1 × 10−8 to 1 × 10−7 M with limit of detection (LOD) of 6.3×10−9 and 7.1 × 10−9 M, and limit of quantification (LOQ) of 2.1 × 10−8 and 2.3 × 10−8 M, at pH 3.5 and 9.0, respectively. The proposed method was tested for CP determination in spiked urine samples, enabling determination of low concentrations of CP. PB - Elsevier B.V. T2 - Journal of Pharmaceutical and Biomedical Analysis T1 - Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine VL - 36 IS - 4 SP - 899 EP - 993 DO - 10.1016/j.jpba.2004.08.035 ER -
@article{ author = "Aleksić, Mara and Ilić, Miloš and Kapetanović, Vera", year = "2004", abstract = "Abstract It was found that the reduction of the cefpodoxime proxetil (CP) molecule is strongly influenced by the adsorption. The adsorptive properties of CP were investigated in order to achieve an increase sensitivity of its determination. Validated adsorptive stripping differential pulse voltammetry is applied for the determination of low concentration of CP at pH 3.5 and 9.0 where the best pronounced adsorption effects were observed. The linearity of the calibration curves were achieved from 1 × 10−8 to 1 × 10−7 M with limit of detection (LOD) of 6.3×10−9 and 7.1 × 10−9 M, and limit of quantification (LOQ) of 2.1 × 10−8 and 2.3 × 10−8 M, at pH 3.5 and 9.0, respectively. The proposed method was tested for CP determination in spiked urine samples, enabling determination of low concentrations of CP.", publisher = "Elsevier B.V.", journal = "Journal of Pharmaceutical and Biomedical Analysis", title = "Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine", volume = "36", number = "4", pages = "899-993", doi = "10.1016/j.jpba.2004.08.035" }
Aleksić, M., Ilić, M.,& Kapetanović, V.. (2004). Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine. in Journal of Pharmaceutical and Biomedical Analysis Elsevier B.V.., 36(4), 899-993. https://doi.org/10.1016/j.jpba.2004.08.035
Aleksić M, Ilić M, Kapetanović V. Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine. in Journal of Pharmaceutical and Biomedical Analysis. 2004;36(4):899-993. doi:10.1016/j.jpba.2004.08.035 .
Aleksić, Mara, Ilić, Miloš, Kapetanović, Vera, "Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine" in Journal of Pharmaceutical and Biomedical Analysis, 36, no. 4 (2004):899-993, https://doi.org/10.1016/j.jpba.2004.08.035 . .